This is my first post but just wanted to chime in on the subject.
I've been on Imuran since 2006, and it worked by itself until about early 2010 when I attempted to taper off the drug. I wound up having a severe flare and returned to my normal dose, however it now seemed to be ineffective. I was advised to go on Humira (40mg) as well, which I inject once every two weeks along with 125mg of Imuran daily (2 and a half pills).
I've attempted to taper off Imuran a couple times since starting Humira, and every time I go down to 50-75mg I start to get abnormal bowel movements and abdominal pain. Nothing too severe, but annoying enough to notice a change in my overall wellbeing.
During each taper I found that I started to feel better on 100mg (two pills), so I would move forward and reduce my dose further by 25mg and my condition would worsen.
At the present moment I am attempting to taper off again. I'm currently at 75mg and I've noticed a change in my overall wellbeing (occasional cramps, decreased appetite, irregular bowel movements, etc...). Which leads me to believe that Humira isn't as effective (for me) without Imuran.
In summary, Imuran and Humira together have worked very well for me to the point where I am in remission. I'm starting to think I should go back to 100mg and just maintain that dose until some geneticist/scientist develops a more permanent fix.
Stats:
27 year-old male
Vegetarian for 8 years (eat fish occasionally)
Do not drink at all
Smoke marijuana regularly
135lbs
Currently on 40mg of Humira every two weeks
Prescribed 150mg of Imuran daily, but have experienced success at a lower dose of 100mg. Doses lower than 100mg cause general symptoms of Crohn's to appear.