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04-05-2013, 09:47 PM   #1
David
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Nickel and Crohn's disease

I found this to be fascinating:
The history of inpatients with Crohn's disease revealed several occurrences of contact dermatitis due to metal ions. Therefore, we considered the question as to whether allergic reactions to amalgam fillings or mercury, delivered in small amounts, could be a factor in the activity of regional enteritis. 23 patients with Crohn's disease (15 females, 8 males), aged from 20 to 44 years were screened by an extended standard patch test (following the rules of the ICDRG). Surprisingly, no case of hypersensitivity to amalgam and/or mercury was found. However, nickelsulfate yielded positive reactions in 39.1% of all tested patients (9/23). In comparison to the normal population this prevalence of nickelsulfate hypersensitivity is distinctly increased. It may be an epiphenomenon of Crohn's disease (sensitization via an enhanced permeability of the irritated mucous membranes for nutritive nickelsulfate) or an etiopathogenetic co-factor. In the latter case regional enteritis might be regarded as an allergic-irritative disease of the bowel.
Source.

A little reading on Nickel in the diet: http://www.melisa.org/nickel.php
04-08-2013, 11:36 AM   #2
mnsun
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Crazy, never heard of "allergic" reactions to nickel/mercury. In any case, this just reminded me to swap out my frying pan for a ceramic one--or at least dispose of scratched metal pots/pans. I'm always boiling water and frying on the stove.

Thanks for the article posting the nickel content of foods. Definitely something to consider.
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04-08-2013, 01:23 PM   #3
Beach
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Interesting that possibly nickel could be a problem with Crohn's disease. Additionally, didn't see it mentioned in the article, I was reading last night that when vegetable oils are hydrogenated nickel is used in the process. Some of the nickel remains in the final product.
04-08-2013, 10:55 PM   #4
David
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As you guys may know by now, I'm of the opinion that magnesium deficiency plays a critical role in the pathogenesis of Crohn's disease.

Magnesium inhibits absorption of aluminum. Aluminum has been found to possible play a role in IBD.

And I just found this. Magnesium inhibits nickel as well. The inhibition of nickel-induced reactive oxygen may tie in with what I posted about here.
04-08-2013, 11:13 PM   #5
David
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Here I talk about peroxynitrite and Catalase.

Nickel interferes with Catalase.

WHOA!
04-08-2013, 11:24 PM   #6
David
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Interesting that possibly nickel could be a problem with Crohn's disease. Additionally, didn't see it mentioned in the article, I was reading last night that when vegetable oils are hydrogenated nickel is used in the process. Some of the nickel remains in the final product.
God, I've just been reading about the hydrogenation process. So basically, the metal catalyst used is either nickel or aluminum due to their cheap cost and BOTH are REALLY BAD for Crohnies.

04-09-2013, 12:04 AM   #7
David
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It turns out that nickel can interfere with Zinc absorption and of course, many Crohnies are deficient in zinc. Zinc is also a co-factor for vitamin D (it is the fingers at the base of the VDR) and of course just about every Crohnie is deficient in vitamin D unless they're supplementing.
04-09-2013, 01:44 AM   #8
alex_chris
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As you guys may know by now, I'm of the opinion that magnesium deficiency plays a critical role in the pathogenesis of Crohn's disease.

Magnesium inhibits absorption of aluminum. Aluminum has been found to possible play a role in IBD.

And I just found this. Magnesium inhibits nickel as well. The inhibition of nickel-induced reactive oxygen may tie in with what I posted about here.
From personal experience I can say I definitely ain't going to stop taking my daily magnesium tablet... And I agree that any deficiency can screw up one's remission, even magnesium.
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04-09-2013, 05:17 AM   #9
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I found out that I was allergic to nickel when I first got my ears pierced when I was 10 or 11 years old. To this day I'm still allergic to nickel. Can't wear any earrings with nickel or I break out. Ears turn red, itch & start weeping.
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04-09-2013, 08:51 AM   #10
David
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I found out that I was allergic to nickel when I first got my ears pierced when I was 10 or 11 years old. To this day I'm still allergic to nickel. Can't wear any earrings with nickel or I break out. Ears turn red, itch & start weeping.
And yet you're very likely eating it regularly
04-09-2013, 02:09 PM   #11
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I found out that I was allergic to nickel when I first got my ears pierced when I was 10 or 11 years old. To this day I'm still allergic to nickel. Can't wear any earrings with nickel or I break out. Ears turn red, itch & start weeping.
Me too.
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04-14-2013, 08:33 PM   #12
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Nickel is one of, if not THE, most common skin allergies, and not only is found in iron and vitamin B-12 supplements, but in many foods, including spinach, oatmeal, soy and legumes.
05-19-2013, 03:36 AM   #13
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Bumping this thread as I think the potential importance is high.
05-19-2013, 04:01 AM   #14
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Bumping this thread as I think the potential importance is high.
I do think it's interesting seeing how many of us with IBD have nickel allergies...
05-19-2013, 07:16 AM   #15
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this is interesting. i had tried a cheaper multi vitamin a while back that i did not tolerate well. when i compaered ingredient levels the only thing that stood out was the cheaper one had alumium and if i recall correctly it also had nickel and the more expensive one had none of these. when i switched back things settled down.
05-19-2013, 09:30 AM   #16
SarahD
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I found out that I was allergic to nickel when I first got my ears pierced when I was 10 or 11 years old. To this day I'm still allergic to nickel. Can't wear any earrings with nickel or I break out. Ears turn red, itch & start weeping.
This happens to me too!
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05-19-2013, 04:09 PM   #17
David
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Ears turn red, itch & start weeping.
Sounds an awful lot like how some of your intestines are. If your skin reacts like this to nickel, just think what your intestines must do when they are constantly exposed to it.
05-19-2013, 07:51 PM   #18
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I found out that I was allergic to nickel when I first got my ears pierced when I was 10 or 11 years old. To this day I'm still allergic to nickel. Can't wear any earrings with nickel or I break out. Ears turn red, itch & start weeping.
Me too. Also shouldn't have worn my engagement ring for so long. It was only gold plated but the majority was nickle. The ring slowly tore off layers of skin (was red and always peeling under the ring). I kept it on cause it had my diamond in it. It's mine! My only. My precious.... Anyway, I don't wear it anymore since we got married and made sure that the wedding band was pure white gold (its nice having a friend who's a jeweler, should have used her help in getting an engagement ring :P).
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05-19-2013, 10:22 PM   #19
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I read a paper that also states how dietary nickel cause dermatitis for some. I haven't dug to find other studies that could be related to the digestive system. I wonder if it reacts to it... It's quite confusing when you take a look at the nickel rich food... most are supposed to be "safe". It would worth being considered.
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05-20-2013, 05:33 AM   #20
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Me too. Also shouldn't have worn my engagement ring for so long. It was only gold plated but the majority was nickle. The ring slowly tore off layers of skin (was red and always peeling under the ring). I kept it on cause it had my diamond in it. It's mine! My only. My precious.... Anyway, I don't wear it anymore since we got married and made sure that the wedding band was pure white gold (its nice having a friend who's a jeweler, should have used her help in getting an engagement ring :P).
I had a similar problem with my wedding ring! White gold has nickel in it -- that's what makes it white! It is typically dipped in rhodium, but as the rhodium wears off, the nickel can leech out into the skin. A couple of months after getting married, I developed a horrible rash with blisters under my ring! The solution? I had to upgrade to platinum!
05-20-2013, 06:10 AM   #21
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Can you get your jeweller friend to reset the diamond in a different ring for you Jenn ?
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05-20-2013, 06:46 AM   #22
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Hmm...interesting...I know I sometimes get red ears when wearing earrings, but I don't know if it is because I don't wear them regularly or because of the metal.

Now, my MOM has an allergy to metals - ANY kind - even gold! She can't wear her wedding ring, necklaces, even the snap on a pair of jeans has to be protected or she will break out where the metal touches.

Now the kicker - she was 'diagnosed' a few years ago with inactive Crohns' during a routine colonoscopy!
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05-24-2013, 12:56 PM   #23
David
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Those of you with nickel allergy. How long does the metal have to be touching your skin before you observe a reaction starting?

Jennifer. You were in remission for MANY years and only recently began to have some symptoms again. Out of curiosity, did the onset of those new symptoms begin around the time you began wearing your engagement ring?
05-24-2013, 01:00 PM   #24
PsychoJane
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That thread is kinda motivating me to work on some sort of epidemiology master regarding this... I wonder if I could find a director interested and/or enough statistics. Even though I am not 100% sure that it is to nickel that I react for me it can take a while... Like I can generally wear my jewel during the winter without having issues but anytime it get more humid I'm getting blisters because it allows it to leech I suppose. When it happened last month I switched my ring to another finger and it took about a week before it happened again. I don't know if it's the time it took before It got moist long enough or it's the time for the reaction itself... I think Ill switch to wood lol. Its safer!
05-24-2013, 01:12 PM   #25
Jennifer
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Those of you with nickel allergy. How long does the metal have to be touching your skin before you observe a reaction starting?

Jennifer. You were in remission for MANY years and only recently began to have some symptoms again. Out of curiosity, did the onset of those new symptoms begin around the time you began wearing your engagement ring?
Hard to say David. I had also been taking care of my grandpa for a few months prior (that caused a lot of stress and the lifting wasn't good for my arthritis). I'm not sure if I can find my older posts but I got engaged on May 5th 2011. If I can find my older posts about symptoms creeping up then its possible we could make that connection.

As for how long it takes to notice a reaction, I'd say at most a few hours (I'm throwing some earrings on and will time it). Possibly less. With earrings I notice itching first which eventually progresses from there. With my ring I noticed the skin starting to peel the following day (it was gold plated so I think that's why it took a little longer).
05-24-2013, 01:40 PM   #26
SarahD
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Those of you with nickel allergy. How long does the metal have to be touching your skin before you observe a reaction starting?
With earrings they'll make my ears itch within a couple of hours of putting the earrings in. I also find necklaces make me itch too and I turn a bit red where they're in contact with my skin, and again that's after a few hours of wearing them. My ears are definitely worse though, they itch very badly and get really red and sore. I no longer wear earrings because of the reaction I have to them.
05-24-2013, 01:56 PM   #27
Cross-stitch gal
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Those of you with nickel allergy. How long does the metal have to be touching your skin before you observe a reaction starting?
It depends. Sometimes it takes a couple of hours and sometimes I can wear them for a day. But, another thing that has happened to me is that I can turn earrings and jewelry green if I can't tolerate it...
05-24-2013, 02:21 PM   #28
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One hour and 10 minutes is how long it took for the itching to begin.
05-24-2013, 02:23 PM   #29
Lisa
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With my Mom, it can take only a few minutes to little longer...wearing pants for a few hours with metal touching her can cause a reaction.
05-29-2013, 11:38 AM   #30
David
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I created a poll about nickel allergy to see if we can get some numbers

http://www.crohnsforum.com/showthread.php?t=51900
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