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Crohn's Disease Forum » Treatment » Methotrexate » Just injected my first dose


06-14-2015, 09:06 PM   #1
CLCH87
 
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Just injected my first dose

I just injected myself with my first dose of methotrexate. My Dr prescribed 25mg once a week, right after my injection (maybe a couple minutes) I was extremely nauseous and then a little later very dizzy. I took some zofran after once I became nauseous, but I'm curious if anyone has any tips on how to avoid this? And how long it's going to last?
06-15-2015, 06:05 PM   #2
pdx
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I've heard that zofran works better if you take it before the nausea-inducing event. My daughter takes oral methotrexate, and her doctor told her to take zofran 2 hours before she takes her MTX. That takes care of most of her nausea. She does get a little dizzy too, but she takes the MTX just before bed so that she sleeps through the worst of it.

Good luck. MTX has worked well for my daughter.
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Daughter E (15) dx with Crohn's 12/18/14 at age 12

Current treatment:

Remicade started 12/24/14 (currently on 9 mg/kg every 6 weeks)
Oral methotrexate restarted 12/2/16 (15 mg weekly)
vitamin D, folic acid, multivitamin, Prozac

Past Treatment
90% EN via NG tube 2/9/15 - 4/2/15
50% EN via NG tube 4/3/15 - 4/18/15
Supplemental EN via NG tube 5/7/15-6/19/15
Budesonide 3/3/15-6/30/15
Oral methotrexate 3/13/15 - 5/14/16 (15 mg weekly)
Topical clobetasol for Remicade-induced psoriasis
06-15-2015, 07:27 PM   #3
CLCH87
 
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I've heard that zofran works better if you take it before the nausea-inducing event. My daughter takes oral methotrexate, and her doctor told her to take zofran 2 hours before she takes her MTX. That takes care of most of her nausea. She does get a little dizzy too, but she takes the MTX just before bed so that she sleeps through the worst of it.

Good luck. MTX has worked well for my daughter.
Thank you! I think I'll try that for my next injection. One of my normal symptoms is nausea so I take zofran regularly but I also have Phenergan to take when it gets really bad. I'm really hoping this works, I've had allergic reactions to almost every biologic, so this is my last chance to avoid surgery, and hearing it worked well for her gives me hope
06-18-2015, 05:25 PM   #4
crohnsinct
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Yeah my daughter takes hers at night as well. Most her side affects follow 36 hours later though.

Just checking...are you taking folic acid as well...that helps with the side effects.
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Daughter O dx 2/1/12 at age 12
Crohns & Remicade induced Psoriasis
Remicade
Methotrexate (12.5mg wkly - oral)
Vit d 2000IU
Multi vitamin plus iron
Calcium
Folic Acid
Previously used - Prednisone, Prevacid, Enteral Nutrition

Daughter T dx 1/2/15 at age 11
Vitaligo, Precoscious puberty & Crohns
Methotrexate (15mg weekly oral)
Enteral Nutrition
Entocort
IBD-AID Diet
Vit d 1000IU
Calcium
Folic Acid
Previously used: Mtx injections
06-19-2015, 12:23 AM   #5
CLCH87
 
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Yeah my daughter takes hers at night as well. Most her side affects follow 36 hours later though.

Just checking...are you taking folic acid as well...that helps with the side effects.
Yes, I am, the Dr put me on 1mg 2x a day everyday. Along with that he prescribed me Prednisone but I've had Cushings induced from Prednisone before so I'm taking it but very unwillingly.

I was wondering if anyone knew if pain in the upper right quadrant could be associated with the methotrexate? I've been hungry again for the first time in weeks but every time I eat I'm getting a terrible pain under my right breast that wraps around to my back and shoulder.
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