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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Combination Therapy - Remicade and Imuran


03-02-2016, 06:41 PM   #1
twob
 
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Combination Therapy - Remicade and Imuran

Anyone have any research or experience with Remicade and Imuran. Drs want my 19 year old to be on both. He was on Imuran for 5 years and all was great. he discontinued and now disease is back. We are concerned about Lymphoma risk etc.

thank you.
03-02-2016, 10:30 PM   #2
DJW
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Hi, I'm on both and not had any issues.

I don't have a link to provide but I have read the risk of cancer goes from 2 in 10,000 to 6 in 10,000
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03-02-2016, 10:47 PM   #3
Clash
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Sorry, no experience with imuran here. My son uses methotrexate and humira but he was originally on methotrexate and remicade.
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C age 19
dx March 2012 CD

CURRENT MEDS: MTX injections, Stelara


Dx May 2014: JSpA
8/2014 ileocecectomy
9/2017 G tube

PAST MEDS: remicade, oral mtx, humira
03-14-2016, 07:53 AM   #4
Silverbird
 
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Imuran or 6MP strengthens the effect of Remicade. Chances of getting cancer from these treatments together are still very very small compared to the risk of the disease returning in a much worse state. Personally, I would definitely consider taking this step.

(Totally stupid and anecdotic argument: I've been on remicade + 6MP for 3 years and I'm totally fine )
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Crohn's disease since Dec 2012 | Perianal abcesses & fistula since June 2009

Remicade 300mg/6weeks | 6MP 25mg & Allopurinol 100mg every other day
03-14-2016, 10:47 AM   #5
ronroush7
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I am on Imuran for a number of years. I was on Remicade about three years ago and had no issues with the two.
03-14-2016, 11:25 AM   #6
my little penguin
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Ds was on 6-mp then remicade ( allergic rxn) then switched to humira and Mtx for the past 3 years.
He is 12
No issues
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03-14-2016, 04:19 PM   #7
Maya142
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My kiddo has been on Remicade and Imuran. I was worried too, but no issues at all - no increase in infections or anything like that. She had nausea with Imuran, but it eventually went away.

She is now on Imuran and a different biologic.
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05-08-2016, 10:35 PM   #8
leloupaccroupi
 
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Hi, I'm on both and not had any issues.

I don't have a link to provide but I have read the risk of cancer goes from 2 in 10,000 to 6 in 10,000
I was told 2 in 100,000 to 6 in 100,000, by my GI two weeks ago, I'm 25, very newly diagnosed and was assigned combination immunosuppressant/biologic treatment off the bat.

Hope all is well and treatment improves!!
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Diagnosed Severely active CD April 28 2016

Addison's since 2003
Failed Imuran: Acute Pancreatitis
Awaiting First Remicade Dosage

Amnium Vincit Omnia;
The Mind Conquers All
05-18-2016, 03:53 PM   #9
Tuff
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I'm on both. They are supposed to induce clinical remission better than monotherapy, with fewer side effects.
http://www.medscape.com/viewarticle/720653
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Inflammatory bowel disease may more than double the risk of a serious blood clot in the legs or lungs.
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Stelara, Warfarin, calcium, Vitamins B12, D.
Previously: 5-Asa, Cipro, Flagyl, Prednisone, Aza, Remicade.
Pulmonary Embolism, DVT's, osteopenia, Peripheral neuropathy.
05-20-2016, 12:56 PM   #10
JaimeM
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I was on remicade for 6 years then stopped after my kiddo was born.. I ended up flaring badly after that and was then put on 200mg of Imuran and then started remicade back up.. My liver enzymes ended up getting high so they halved my dose of imuran and kept me on remicade too. Now everything has evened out and I'm doing good.. Still have some abd pain but doing pretty well. A flared liver kind of sucks tho, it's painful.
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Diagnosed Terminal Ileum Crohns 2008
Remicade 6yrs
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Switched to Cimzia but didn't work 2015
Back to Remicade and added Azathioprine 2016
05-20-2016, 12:58 PM   #11
ronroush7
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I am sorry about the liver.

05-20-2016, 12:59 PM   #12
JaimeM
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I am sorry about the liver.
It's much better now.. It hurt almost as bad as my crohns did though. My liver enzymes got up to like 200ish before they started coming down.. my wbc tanked too but that was just for a week.. I started drinking a ton of water(I had read that helps flush out toxins) So I've been doing better since then.
05-20-2016, 01:02 PM   #13
ronroush7
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Great

05-22-2016, 01:44 PM   #14
leloupaccroupi
 
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I'm so sorry to hear about your liver flare!! That sort of upper abd pain is so much worse than lower GI cramps (at least IMO) I'm happy to hear you're on the mend though!! Keep kicking butt and keep us updated!
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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Combination Therapy - Remicade and Imuran
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