No. I took both the Sulfa and Asacol for Crohn's (which has been located mainly in my ileum). Both are time release tablets and do release in the ileum and colon. Both say they are for UC but if your Crohn's is near the colon (ileum) then both will work for you (assuming you don't have side effects form them that is).I am taking it for Crohns though... is that abnormal?