Thanks for shedding some light on this for me. I ran the raw data through Promethease. There was no allele listed with gs221 that I asked about in my original post, just the gene (no letters in parentheses).Also you can have a gene but not the mutation
You have to have a specific SNP number with a specific risk allele combo ( a:g etc...)
Again SNP are extremely primitive in the land of genetics
Most genetist wont touch them .
The SNP association is only based on a single paper study a single group who happened to have that SNP risk allele . Sometimes there are multiple groups or papers so a stronger correlation can be made. Again just a word of caution since for every paper proving one thing there are multiple papers disproving the same thing
It's interesting you mention gene-to-gene interaction, because my son's data had a handful of genes that were "protective" against auto-immune and IBD.So interesting that there's such a large variation -- my daughter had 142 different SNP associated with IBD.
One of the rheumatologists we see (who does a LOT of research) does not like the 23 and me data - says it does not take into account gene to gene interaction, whatever that means. So I just take it with a grain of salt.
My report has a search box at the top left. I type in gs221 and it comes back with this result, highlighted in a red box.Couldn't find it. Would it be under IBD (using the Promethease report)?