Are there any new biologics coming out in the pipeline for Crohn's? Kinda worried that this stelara might not end up working.
Stelara isn't a 1st line therapy for Crohn's. Kinda weird they would put you on that right away. Remicade is the most effective of the biologics, but even that doesn't work for everybody.Stelara is the only one I tried. Been on it for 4 weeks.
In my last appt my doc said Entyvio isn't as good for Crohn's (better for UC), and even less so for people that fail Remicade based on the data. She isn't a big advocate of trying every TNF therapy as they all have the same mechanism of action.Second that ^^^^^
First line is remicade
Then humira
Then cimzia or Simponi or entivyio as third line
Last ditch effort is Stelara for Crohns
After that there is ivig and stem cell or fecal transplant
I was given the option for stelara because of it's safety profile. The only reason it is not considered first is because it is only newly approved for Crohn's. Most docs are not comfortable prescribing this med because it is so new. There is no reason why stelara can't be used firstline.
Based on it's years of use in treating psoriasis, Stelara (ustekinumab) has a lower risk of serious infection than Humira and especially lower than Remicade:Question
You keep referring to a better safety profile ?
What particular risk association does other biologics (remicade humira etc..) specifically have that Stelara does not ?
Do you have a link to a study or paper etc...
I would really like to read it since Ds is on Stelara now
Ds has been on both to my knowledge the only lower risk is for TB since anti tnf stops the body from fight against TB
And
Il12/il23 are not involved in that process-so theoretically lower TB risk
But risk of fatal cancer /infection and fatal brain issues still are associated with Stelara
I think that might have happened to me.One rare side effect of anti-TNF is peripheral neuropathy. Since I got it from Remicade, I don't think I can try the rest of them. So I'm on Stelara. If it doesn't work, I hope there are other things coming down the pipe. I'd like to keep my large intestine for a while longer.