Don't know what the exact mg are, it's probably 250 or 500mg for those. There's negatives just like with any drug. While these antibiotics are relatively safe, antibiotics create resistance. Also, one of those antibiotics is used to treat people with TB and some other infections, which isn't a good thing when you're on antibiotics for so long.
You should ask your GI, antibiotics are a viable treatment when other medication has failed.
Also, this is about crohn's disease, antibiotics aren't effective for UC afaik.
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Another small point is that let's say that this combo works, because a small study of 10 children isn't conclusive, that doesn't mean MAP is the cause or even relevant to this diseasse. It's just as likely that it targets another pathogen, and I know that if it does work, some people will say it's because one of those antibiotics is also mildly anti-inflammatory, but it's not enough to put 8 out of 10 kids in remission I'm sure. It's just a small study, it's meaningless on it's own really.
But that bacteria are directly related to crohn's disease isn't open for discussion anymore, all genetic predispositions in crohn's disease are related to bacterial handling, they all point to innate immunodeficiency.
There's only a few hypotheses that still make sense to me:
-persistent pathogen
-loss of tolerance towards commensal bacteria, which is a bit hard to explain because crohn's disease has skip lesions
-some immune response against a microparticle of unknown origin