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Crohn's Disease Forum » Treatment » Resveratrol


06-29-2010, 08:03 PM   #1
matty
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resveratrol

Resveratrol, a potent antioxidant found mainly in grapes, improved symptoms of inflammatory bowel disease (IBD), including intestinal inflammation, diarrhea, and rectal bleeding, in a new study. Mice that received resveratrol also had a better survival rate than those not treated.

Resveratrol is a phytonutrient (phyto means “plant”) that is the subject of considerable research because of its anti-inflammatory, antioxidant, anti-tumor, and immune system boosting properties. Previous studies have suggested that resveratrol enhances brain function and builds resistance to stroke, helps with weight loss, inhibits prostate cancer cell growth, and protects against diabetes.

Resveratrol’s anti-inflammatory abilities are of special interest for possible treatment and prevention of inflammatory bowel disease, of which ulcerative colitis and Crohn’s disease are the two most common types. In the current study, which appears in the European Journal of Pharmacology, researchers conducted a placebo-controlled study in which one group of mice were given 20 mg of resveratrol per kilogram of food and the other group received placebo. The study period lasted 30 days.

After the 30 days, the researchers induced colitis in both groups using a substance that inflames the intestinal walls. Mice in the resveratrol group experienced less severe and less frequent symptoms than mice in the control group. Specifically, treated mice had less severe weight loss, dehydrating diarrhea, and rectal bleeding than those not treated. In addition, 40 percent of the untreated mice died, while none of the resveratrol-treated mice did.

Resveratrol also appeared to help the mice recover from colitis better than their untreated counterparts. The researchers note that their findings suggest resveratrol may be an effective treatment for inflammatory bowel disease, and that its lasting effects may help prevent these inflammatory conditions as well.

The inflammatory bowel diseases ulcerative colitis and Crohn’s disease affect about 1 million Americans, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Crohn’s disease tends to impact the small intestine, although its effects can reach beyond that point. Ulcerative colitis usually causes inflammation in all or part of the large intestine. Diarrhea, abdominal pain, fever, and weight loss are symptoms of both conditions.

The causes of these inflammatory bowel diseases are not known, and there is no known cure. For now, medications are usually prescribed to control the symptoms, but drugs have side effects and are limited in their effectiveness. The addition of resveratrol to the list of possible treatment options would be welcome by those who suffer with these inflammatory bowel diseases.

SOURCES:
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Sanchez-Fidalgo S et al. European Journal of Pharmacology 2010 May 10; 633(1-3): 78-84

I read this today from another ibd support group i;m on and thought it would be interesting for everyone to read.
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06-29-2010, 10:18 PM   #2
Keona
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they must have watched Dr. Oz recently. I heard about this on the TV show. Sounds interesting however there is no real proof that this will work and there wont be for about 10 years. Apparently to get the benefit from the grapes in the wine (and it has to be oxygen deprived grapes) you would have to drink 180 bottles a day...so, they came up with the resveratrol. It will be out soon as they are on their last stage of testing.
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06-30-2010, 03:36 PM   #3
Astra
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Yeah I read about this on here somewhere only last week!
apparantly it's the actual skin on the red grape and it's a certain variety, not all red grapes, but very interesting!

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Last edited by Astra; 06-30-2010 at 03:42 PM.
06-30-2010, 03:45 PM   #4
Silvermoon
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Neato! Thanks for the info, Matty!
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07-25-2012, 07:04 PM   #5
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I know this topic is really old but decreasing collagen content for fibrosis is so important.

Inflamm Bowel Dis. 2012 Apr

Resveratrol has antiinflammatory and antifibrotic effects in the peptidoglycan-polysaccharide rat model of Crohn's disease.

Rahal K, Schmiedlin-Ren P, Adler J, Dhanani M, Sultani V, Rittershaus AC, Reingold L, Zhu J, McKenna BJ, Christman GM, Zimmermann EM.


Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Abstract

BACKGROUND:

Resveratrol has antiinflammatory and antifibrotic effects. Resveratrol decreases proliferation and collagen synthesis by intestinal smooth muscle cells. We hypothesized that resveratrol would decrease inflammation and fibrosis in an animal model of Crohn's disease.

METHODS:

Peptidoglycan-polysaccharide (PG-PS) or human serum albumin (HSA) was injected into the bowel wall of Lewis rats at laparotomy. Resveratrol or vehicle was administered daily by gavage 1-27 days postinjection. On day 28, gross abdominal and histologic findings were scored. Cecal collagen content was measured by colorimetric analysis of digital images of trichrome-stained sections. Cecal levels of procollagen, cytokine, and growth factor mRNAs were determined.

RESULTS:

PG-PS-injected rats (vehicle-treated) developed more fibrosis than HSA-injected rats by all measurements: gross abdominal score (P < 0.001), cecal collagen content (P = 0.04), and procollagen I and III mRNAs (P ≤ 0.0007). PG-PS-injected rats treated with 40 mg/kg resveratrol showed a trend toward decreased gross abdominal score, inflammatory cytokine mRNAs, and procollagen mRNAs. PG-PS-injected rats treated with 100 mg/kg resveratrol had lower inflammatory cytokine mRNAs (IL-1β [3.50 ± 1.08 vs. 10.79 ± 1.88, P = 0.005], IL-6 [17.11 ± 9.22 vs. 45.64 ± 8.83, P = 0.03], tumor necrosis factor alpha (TNF-α) [0.80 ± 0.14 vs. 1.89 ± 0.22, P = 0.002]), transforming growth factor beta 1 (TGF-β1) mRNA (2.24 ± 0.37 vs. 4.06 ± 0.58, P = 0.01), and histologic fibrosis score (6.4 ± 1.1 vs. 9.8 ± 1.0; P = 0.035) than those treated with vehicle. There were trends toward decreased gross abdominal score and decreased cecal collagen content. Procollagen I, procollagen III, and IGF-I mRNAs also trended downward.

CONCLUSIONS:

Resveratrol decreases inflammatory cytokines and TGF-β1 in the PG-PS model of Crohn's disease and demonstrates a promising trend in decreasing tissue fibrosis. These findings may have therapeutic applications in inflammatory bowel disease.

Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
05-05-2015, 06:36 AM   #6
Crohn2357
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Does anyone take resveratrol for crohn's or colitis? I'm wondering about the dose particularly.
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