05-21-2011, 09:22 PM   #31
billyjoel
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Look, I know that poop is gross, but if it works why wouldn't anyone try this?? As long as the feces is disease free how are fecal transplants any stranger than blood transplants other than blood transfusions have been an integral part of medical treatment for some time now?
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06-03-2011, 07:08 AM   #32
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Patients With Bowel Disease Eager To Test "Fecal" Therapy

The first study of the social and ethical issues associated with a provocative approach to treatment for ulcerative colitis has found that the majority of potential patients are eager for what is now called "fecal microbiota transplantation" to become available, although many have concerns about donor selection, screening, and methods of delivery.

Bacterial aggregates derived from fecal matter have been used sporadically to treat gastrointestinal disease for more than 50 years. These were often last-ditch efforts aimed at restoring microbial balance for patients with raging intestinal infections. More recently, the approach has produced lasting remissions for a small number of patients with a common disease: ulcerative colitis.

"Once patients get past the yuck factor they find the concept appealing," said study author David Rubin, MD, associate professor of medicine at the University of Chicago. "They perceive it as 'natural,' similar to probiotics. Patients with severe inflammatory bowel disease tend to develop a high tolerance for therapies that others might consider unorthodox."

Fecal microbiota transplantation (FMT)-also known as fecal bacteriotherapy, among other names-is an effort to calm a troubled bowel by reintroducing the vast diversity of collaborative bowel inhabitants after the usual mix has been disturbed. More than 1,000 different strains of bacteria co-exist peacefully in the typical healthy bowel. But when the delicate balance is altered, by antibiotics or other causes, a few strains can become dominant, leading to severe diarrhea, inflammation and tissue damage.

The first FMT cases, dating back to 1958, were used to treat life-threatening infections caused by aggressive bacteria that had overwhelmed the bowel, driving out the competition. When antibiotics were unable to control the infection, physicians were able to restore balance by injecting the full range of gut bacteria. They did this by collecting fecal matter from a healthy donor and injecting it into the patient's colon.

In 2003, a team led by Australian physician Thomas Borody published a report on successful treatment of six patients with longstanding ulcerative colitis with this approach. "Complete reversal of UC was achieved in all 6 patients following the infusion of human fecal flora," the authors reported. "These 6 cases document for the first time the total disappearance of chronic UC without the need for maintenance treatment."

"This is a fascinating idea, and the early studies show great promise, but we found that no one had looked at the social issues surrounding fecal transplantation," said Rubin. "Before we offer this, we wanted to find out how patients understood the process and take a look at the ethical issues that could also be raised by this therapy."
Like an organ transplant, fecal microbiota transplantation begins with finding a donor, often a family member. The treatment team collects a fresh stool sample, at least 200 to 300 grams. The sample is mixed with salt water in a blender and filtered to remove particulate matter. It can be administered to the recipient through a colonoscope, as an enema, or-when the inflamed region is higher in the colon-through a naso-gastric tube.

Rubin and colleagues Stacy Kahn, MD, and Rita Gorawara-Bhat, PhD, organized six focus groups in 2009-2010 with patients or parents of children with ulcerative colitis to "explore the attitudes and concerns" raised by this approach. They published their findings in the June issue of the journal Inflammatory Bowel Disease.

They found that 21 out of 22 patients or parents of patients were interested in trying FMT for themselves or their child; most wished it were already available. They viewed the treatment as more 'natural' than using drugs to control the disease, and easier and safer than currently available therapies. Many compared it to probiotics, a popular alternative therapy among patients with colitis.

The major concerns were focused on how donors would be selected and screened. Patients wanted healthy donors, usually family members, and asked that even their diet and medications be considered. A donor who had eaten peanuts recently, for example could be hazardous for a recipient with peanut allergies.

Physicians recommend a workup similar to that of an organ donor, with careful screening for multiple pathogens, including HIV, hepatitis and other viruses, as well as various parasites and worms.

The "yuck" factor came up in the focus group discussions of bacterial delivery. Patients and parent were comfortable with the idea of a "spray" colonoscopy or delivery via enemas, but were disturbed by the idea of using a naso-gastric tube for the transfer of fecal bacteria, although this method has been used to treat Clostridium difficile infections.

"What our study ultimately tells us is that patients are not only tolerant of this therapy but are eager for it to become available," Rubin said. "A few have already tried this strategy at home, using 'protocols' they found on the internet and tools available at any drug store."

"We hope to begin offering FMT this fall," he said, "in a carefully controlled, clinical-trial setting."

"We are getting at least one phone call a week from patients asking about the treatment and when we are going to start treating patients," said co-author Stacy Kahn, MD, instructor of pediatrics at the University of Chicago.

There are many things we do not yet know about the risks and benefits of FMT, the authors agreed. The safety of such a treatment and broader implications of risk remain unconfirmed, so careful preparation and more study is necessary before this can be offered to patients with ulcerative colitis.

"Many patients do benefit from proven traditional therapies," Rubin said, "which should always be considered before experimental treatments, no matter how attractive they may sound."

The National Institutes of Health, the University of Chicago's Clinical and Translational Science Award, and the Gastrointestinal Research Foundation supported this study.

Source:
University of Chicago Medical Center
http://www.medicalnewstoday.com/releases/227303.php
08-01-2011, 02:38 AM   #33
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If they could do this for Crohn's, I would do it in a heartbeat. It's a little gross, but totally worth it if it just helps for a few months.
08-01-2011, 04:55 PM   #34
crohnicaly stinky
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It seems so simple to me. If you need the bacteria then a small amount of fecal matter could be used to grow more bacteria in some sort of solution and then inject that as an enema. Maybe a poopfusion is just cheaper and easier.
08-01-2011, 10:57 PM   #35
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Ugh I'm on the boat about this one...it's incredibly disgusting and I would probably vomet if I had to do it BUT if I suffered from terrible bouts of C Diff maybe it'd be worth it...sucks that there is no possible cure for crohns but UC has a few options if not limited and gross options at that...Crohns and I just have to make nice...you think if I apologize he'll accept it and calm down? What if I gave him all my lunch money???
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08-02-2011, 12:45 AM   #36
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I've had C. Diff three times in four years, and as for trying this....yeah, it's not gonna happen!
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08-02-2011, 09:45 AM   #37
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I don't know what to think.

All I know is that I'm laughing my ass off. Somewhere between blenders and robots w/ apple pie.

Thank you for the smile today <3
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08-02-2011, 10:08 AM   #38
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There's definitely an ick factor to this, but I wouldn't rule it out if I had c.diff.
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08-02-2011, 10:10 AM   #39
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I'll agree with many of the comments made. Oh sick was my first reaction!
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08-02-2011, 12:07 PM   #40
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I would be interested in learning how a person with Crohn's reacts to this treatment. UC is a different animal altogether.

A friend of mine went into clinical trials for a treatment for Crohn's that involved large amounts of the "good bacteria"-like what you get in cultured food products but at a much higher controlled dose. He felt great initially but then developed a terrible infection, starting in the bowel and spreading to his bloodstream. He was hospitalized for two weeks for it.

The research doctors told him it's not just the nasty bacteria-c.diff, h.pylori, e.coli, etc that cause illness. Apparently even large amounts of good bacteria send a red flag to a Crohnnies' immune system. My friend had built antibodies to the new bacteria and because it was still being introduced it led to infection.

I take probiotics as well as eat large amounts of Greek yogurt and so far I haven't had c.diff return-even with taking high dose antibiotics, Methotrexate, and Remicade. Let's hope it keeps on working!
08-02-2011, 01:03 PM   #41
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I had C. diff. quite a few years ago. I still remember how sick I was. I can't say I wouldn't do just about anything to get rid of it, but I do think the colonoscopy spray or the enema would be more appealing than the naso-gastric tube. YUCK!!

Can't they just grow that stuff, instead of having a fecal transplant. That is the part that is the most yuck.
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09-10-2011, 05:36 PM   #42
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This has got to be a folk rumor, like waking up in an icy tub with a kidney gone...LOL
01-24-2012, 11:41 AM   #43
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Hey y'all, I'm trying this. It's day 4 today and all is well. I'm on the verge of having surgery and this is a last ditch effort to save my colon. What do I have to lose? So far it's going very well, and yes its gross. But blood, 6 fistulas,2 abcesses with lots of pain and suffering is much grosser and it never ends. People who say they would never try it probably arent suffering much.. So, here we go.. I have Crohns and am hoping it works. Im doing it every day for 10 days then I'll do it three times a week for a month and then twice a week for a couple months. I'll keep you updated how I'm doing. Bree
01-24-2012, 11:44 AM   #44
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Hi Bree! Please do keep us updated! If you're comfortable giving additional information, who is doing this for you? Would you be open to sharing some of the methodology they're utilizing?

I pray it makes a positive difference for you.
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01-24-2012, 12:16 PM   #45
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Bree. Good luck to you! Thank you for sharing your experience. I hope it works for you.

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01-24-2012, 12:51 PM   #46
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My G.I. is doing a study on this. He has not talked to us about it because my son so far has responded to conventional treatment but my friend's son is enrolling in the study. His case has been refractory so far and they have exhausted treatment options. His dad will be the donor. I am keeping in contact with her about his condition and will let you guys know what happens. My G.I. is Dr. Kunde in Grand Rapids Michigan at Helen DeVos Children's hospital. He is doing this study in pediatric patients. I think there are some real breakthroughs coming for Crohn's glad you guys are here to share.

Tiffany
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01-24-2012, 01:46 PM   #47
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Well, I'm alll FOR this!!!! I hope it works for you! Please do keep us updated.

After all, you have plenty to lose and alot to gain. If it works, fabulous!
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01-25-2012, 03:40 PM   #48
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Well, I'm on day five of transplants . Everything is going great. I had been on flagyl and cipro for 10 days then five more of Flagyl. It wasn't to prepare for this, it was because I was a total mess, I have 3 abcesses and several fistula that I know of. A huge absecess came up 4 days after starting the antibiotics. It has been getting bigger bleeding and very sore throughout taking the antibiotics. Lots of blood & ect. Been off antibiotics 2 weeks before starting transplant. Today I'm a LOT less sore, less blood, abcesses is smaller and less sore! I cried for a half hour. Just happiness... I feel like there's hope. Too soon to know for sure if this is working. I'll keep posting my progress. Please feel free to contact me. Bree
01-25-2012, 04:14 PM   #49
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My boyfriend thinks I'm weird now I've just asked him to keep some of he's poo by for me / If its anything like the red on white wine thing then I want to give it a go? Lol xx
01-25-2012, 06:07 PM   #50
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Oh, Bree I'm so happy for you!! I hope it works wonders. Keep us in the loop because if it does work, my husband will be pooping into a ziplock bag soon! Hell, I tried everything else!
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01-25-2012, 07:05 PM   #51
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Best of luck, Bree, and do keep up posted. My doc just mentioned this yesterday (not that he has done it, but someone else has asked him to look into it). Can't wait to hear more!
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01-26-2012, 02:14 AM   #52
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I hope that this works for you Bree!!!
01-27-2012, 06:55 AM   #53
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This guy is one of my gastroenterologists, we fly up to Sydney to see him. He told us that they've just found that 98% (I think, more than they originally thought) of people with Ulcerative Colitis can be cured with long term infusions (They used to do it for a week then give up). I'm probably going through with this soon, it might be my only chance to do well in Year 12!

Some people find this treatment repulsive, but I don't, I'm in too much pain to really care or wait for the capsule to be developed.
01-27-2012, 09:26 AM   #54
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Today I'll do number 7 infusion this morning. Last night had cramping and more gas, nothing horrible . but things are happening. Bacteria battles. I'm planning on doing this ten days, then every other day for quite a while. I sure want to keep my bad bacteria from coming back. My biggest abcesses is going away. It's not painful now and is shrinking. I'm still seeing a fair amount of blood. It's very itchy down there, but no pain. I think it's going to be several weeks before there is real progress. The new bacteria has to repopulate. I feel like this is working, but I have no idea how long it's going to take. I think even when everything seems all well I'm still going to do it a few times a week. Bree
01-27-2012, 08:16 PM   #55
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Bree, thank you so much for posting updates on this! To me, the ick factor is really outweighed by the promise of long-term remission or even a cure. Please keep updating and I will keep my fingers crossed for you!
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01-28-2012, 06:31 PM   #56
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Bree, glad to hear the abscess is going away, or at least the pain of it is. I am so hoping this works for you!
01-29-2012, 03:09 PM   #57
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Thanks for sharing! I have heard ALOT about this procedure, especially from having c-diff on and off for 3 years prior to being diagnosed with Crohns, I've heard ALOT about this procedure and know lots of info on it. I have known many people who have had this procedure and it was a life saving thing! Good luck!
01-30-2012, 01:28 PM   #58
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Today is the 10th day. I've been doing the transplant every day. Everything is still great. My bleeding has completely stopped!! Abcesses is still getting smaller. Not sore anymore. I couldn't sit down before. I'm Still having a little pain in the rectal area. That was the worst area and will probably be the last to clear up. Having some gas. Nothing painful. Lots of Stomach noises. My energy level is way up! I went places Saturday and Sunday and didn't get tired out untill later in the day. I haven't felt this good in 6 months! I think this is really working. In a few weeks if everything heals up I'll know for sure. Bree
01-30-2012, 01:59 PM   #59
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Yeah!
01-31-2012, 06:36 AM   #60
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Great news Bree, hope it continues this way for you! Seeing the abcess shrink must be a great visual for your for monitoring your progress - kinda proves it's not just a placebo effect you're experiening! Keep us posted .
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