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12-12-2012, 07:11 PM   #301
Crohn's Mom
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Immunogenicity of the 3 FDA approved anti-TNF-α agents (IFX, ADA, and CTZ) is different.13 It is very important to emphasize that the remission rates for ADA + AZA or CTZ + AZA cannot be assumed to be the same as seen with IFX + AZA in the Sonic Trial! Likewise, safety for ADA + AZA or CTZ + AZA cannot be assumed to be the same as seen with IFX + AZA in the Sonic Trial!

Unfortunately, the Sonic Trial does not address the question, “is there an exit strategy?" It is very important to determine if combo IFX + AZA treatment can be “stepped-down” to just IFX or AZA after 1-2 years of "deep remission" with endoscopic confirmed mucosal healing.

Conclusions:

Crohn’s disease is an incredibly devastating and debilitating disorder. The Sonic trial results are specific for IFX + AZA and should not be empirically applied to ADA + AZA or CTZ + AZA. More work needs to be done to develop a stratified treatment strategy, that will balance risks of combination IFX + AZA therapy with benefits of disease suppression.



Trying to search for info on the SONIC trial; specifically Cimzia + AZA; not finding a lot ~ I'm guessing that the bold print is why ??
MLP ~ do you know where I can find research on CTZ + AZA ??

edit: and this SONIC trial was based on all "naive" patients
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and Austin (18)
DX: Crohn's 7/2013
12-12-2012, 07:48 PM   #302
my little penguin
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Do key word search in google scholar first
Then go from there.
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12-12-2012, 07:50 PM   #303
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We'll I can probably search for days, but with this particular trial I won't find anything cause it was based solely on Remicade + Aza/6mp.
12-12-2012, 07:57 PM   #304
my little penguin
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Not sonic trial but search Aza and cimzia then you can see if there were any smaller trials
12-13-2012, 05:38 AM   #305
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Thanks for the update T...

So good to hear that the nurse was able to allay your concerns somewhat T. Still enough to take on board though.

I'll be honest mate, I know I have said this before but I am still in two minds about the previous use of the 6MP. I know it didn't help Gab last time but I still wonder if her disease was beyond what 6MP could deal with at that time.

I don't know, I am probably way off the mark with it.

In Matt's case I don't think the Imuran helped all that much but perhaps it did help to keep him stabilised, it certainly didn't reverse or heal the complications. He had 2 fistula's and abscesses and if anything I think the antibiotics and IV Hydrocortisone did as much good as anything until surgery.

Thinking about you guys and wishing nothing but the very best of love, luck and well wishes.

Dusty. xxx
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12-14-2012, 04:30 AM   #306
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Thinking of you, and wishing that it was easier for you, hon!
but yay for pseudo polyps and sinuses!

Wishing she is feeling better quickly...
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12-18-2012, 09:34 PM   #307
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Guess what - I have my girlie home ! For a whole week !
Momma's happy

She started her Imuran today ... Crossing my fingers that it works and she doesn't get any awful side affects !
12-18-2012, 09:39 PM   #308
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I can see you doing the HAPPY dance! enjoy every minute with her!

Shhh... No negatives thoughts re imuran!!! All will go well!
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May-July 2011 - 6 wks Exclusive EN via NG tube - 2000 ml/night, 1 wk IV Flagyl
July 2011-July 2013 - Supplemental EN via NG, 1000 ml/night, 5 nites/wk, Nexium, 40 mg
Feb. 2013-present - Remicade, 5 mg/kg every 6 wks
Supplements: 1-2 Boost shakes, D3 - 2000 IUs, Krill Oil
12-18-2012, 09:49 PM   #309
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Awe thanks Tess !

Honestly, the only side effect I am really thinking of is hair loss.
She seems to have a history of losing a lot of hair with new meds, and her hair has finally grown back in and looks so gorgeous again! I'd hate to see her lose it again ya know.
But you're right ~ positive thoughts only from here on out !!
12-18-2012, 10:14 PM   #310
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Well T if it helps at all...... Methotrexate did positively ZERO for Claire's JRA. Ironically, now it seems to be doing the trick (along with the rest of our cocktail).

Sometimes 2+2 CAN = 5.

Big hug!!!

J.
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No more Enbrel, Stelara, Methotrexate, Allopurinal or 6MP
12-18-2012, 10:15 PM   #311
my little penguin
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sending lots of good med vibes her way....
12-22-2012, 09:19 PM   #312
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T, I'm sorry to see Gabs is still going through so much. Glad she's still got that awesome sense of humor though. I know it lightens your load immensely Merry Christmas!!
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12-23-2012, 07:55 PM   #313
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Yay for home T!!!! Sooooo happy for Gab that she will get spoilt and sooooo happy for you that you get to eyeball her for a whole week!

Imuran! Well I know that cause of your other thread. Just takes me forever to catch up......must be the fecking dementia, I just keep answering the same posts over and over and over! God I hope it does the trick for her mate, I am wishing so hard I reckon I am fit to burst!

Sending loads and loads and loads of love and luck that nothing but good comes your way!

Onwards and Upwards!
Dusty. xxx
12-25-2012, 01:53 PM   #314
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We had a successful Christmas morning

Barely got Gab to wake up and join us for gift opening - she's very happy with her new iPad - and now she's been back in bed the whole day. Poor girl is feeling awful today
I don't get it ...
12-25-2012, 02:04 PM   #315
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Sorry to hear about Gabs.
Grace is still ill but happy to have her Cinderalla doll to sleep with. Strange Christmas that's for sure! Still try to enjoy it!
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12-25-2012, 02:23 PM   #316
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Oh no T......I can well imagine how heartbreaking this is for you.

I hope more than anything that Gab is soon able to get on top of things again, bless her. Seeing your child sleeping all the time is bad enough but at this time of year...well it just makes it all the worse.

Thinking of you guys and sending loads of love and healing thoughts your way.
Dusty. xxx
12-25-2012, 04:05 PM   #317
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Merry Christmas. Hopefully Gab will shortly be on the improve.
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Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)
12-25-2012, 04:25 PM   #318
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Sorry T, hope she gets better soon.
12-26-2012, 09:55 AM   #319
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T, so sorry Gabbie wasn't feeling well yesterday Hoping today's a better day for her!
12-26-2012, 10:00 AM   #320
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Glad she liked her iPad. Hope she starts to feel better soon. We are starting 6mp in January
12-26-2012, 10:20 PM   #321
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Good luck with the 6mp Sascot !

Thanks everyone for the well wishes
She's not feeling any better, but she's doing "ok". She seems to think she may be getting the flu, or having some sort of allergy issue - sure hope it's not the Imuran :/
12-27-2012, 02:27 PM   #322
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Oh T......I hope it's not the Imuran too.

How is Gab now? Any sign that she be right about flu/allergy?

Thinking of you both.
Dusty. xxx
12-27-2012, 06:12 PM   #323
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Thanks Dusty !
I just got home from work and she had slept all day
We're gonna take her out to eat, and she's gotta go back to her apartment for the weekend because of work. I tried to talk her into calling in, but nope.
She called her GI office today but didnt get a call back. Hopefully it's a cold and ANOTHER round of antibiotics will knock it out.
This poor kid needs a break already!
12-27-2012, 06:15 PM   #324
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Oh man T, she surely does...

I hope they get back to her soon. She is one strong and inspiring young lady but she is well overdue for Lady Luck to pay a visit.

Dusty.
12-30-2012, 07:27 PM   #325
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So she now has a very large lymph node in her armpit. It's kind of tender (thankfully?)
This IS because of possible infection/flu/cold right ??

Still no return call from the GI's office, and her GP is on vacation until the 7th, and the schools clinic is closed as well for the holidays ~ ugh !
12-30-2012, 08:14 PM   #326
my little penguin
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Is there an oncall Gi since its evening????
DS had a pea size sore lymph node in his arm pit earlier this year- I freaked
Ped checked it and declared him just fine - he didn't even have a cold then but had one earlier so ......
Hugs
12-30-2012, 08:25 PM   #327
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C had a swollen lymphnode after starting remicade but it was located under his chin, I freaked too, MLP) but GI said it was fine. C later tells me, oh that lymph node swells when my allergies act up all the time...oh good to know now son since you've had allergies your whole life!! Hugs!
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12-30-2012, 11:47 PM   #328
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Im following along and praying for Gabs. Keep us posted. And YES that lymph node WILL be because she's been sick. Think how much better you'll feel when the doc agrees.

Love you -

J.
12-31-2012, 07:10 AM   #329
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WorryKat here T! Worry, worry, worry...remember that!

If Sarah or Matt had a swollen lymph node I would be freaking too BUT in view of what she has been going through lately I would just console myself with rocking in the corner and NO not plucking my eyelashes out BUT chanting, this is normal, this is normal and all the while doing funny little gestures with my hands to ward off the evil spirits!

I'm sure all will be well T but I will say a chant for you just the same! Good luck mate, sending loads of love and healing thoughts your way!

Dusty. xxx
12-31-2012, 07:28 AM   #330
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Thinking about you and Gabs, T! I'm sure it's nothing
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