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Crohn's Disease Forum » General IBD Discussion » Crohn's disease-associated carcinoma (CDAC)


05-17-2007, 12:39 AM   #1
old hat
 
Crohn's disease-associated carcinoma (CDAC)

Lovely. Learn something new every day or ignorance is bliss?

http://www.pubmedcentral.nih.gov/art...?artid=1494126

Crohn's disease-associated carcinoma. A poorly recognized complication of inflammatory bowel disease.
M E Richards, R R Rickert, and F C Nance
Department of Surgery, Saint Barnabas Medical Center, Livingston, New Jersey 07039-5601.
Abstract
We have reviewed eight cases of Crohn's disease associated carcinoma (CDAC) of the bowel treated at Saint Barnabas Medical Center since 1977. Five patients had colorectal carcinoma in areas of dysplasia within histologically recognizable Crohn's disease. One of the large bowel carcinomas was a diffusely infiltrating signet ring adenocarcinoma (linitis plastica), three were mucinous carcinomas, and one contained both cell types. Survival ranged from 4 to 55 months. Three patients developed ileal carcinomas in areas of dysplasia within histologically recognizable Crohn's disease. One of the ileal cancers was a moderately differentiated adenocarcinoma; two were poorly differentiated adenocarcinomas. Survival ranged from 8 to 44 months. The dysplastic changes seen in the bowel adjacent to the tumors in these patients were identical to the characteristic pre-cancerous (dysplastic) changes well described in ulcerative colitis. The histopathologic changes seen in this high-risk group of patients are also similar to those of previously reported CDAC. Those patients with the more diffuse dysplastic changes might have been detected before the development of invasive cancer had they undergone periodic colonoscopic surveillance. One patient in the series with an asymptomatic lesion was, in fact, identified at surveillance colonoscopy. It would appear that Crohn's disease patients have a similar risk for carcinoma previously recognized in ulcerative colitis patients and that surveillance protocols should be developed for this group of patients.
05-17-2007, 10:42 PM   #2
D Bergy
Senior Member
 
Join Date: Apr 2007
Yet another reason to include Turmeric and Ginger in treatment for Crohns.
Both have anti-cancer properties and are anti-inflammatory, antibacterial agents.
Turmeric prevents DNA damage to cells from X-Rays, CT scans.
Ginger helps digestion, sooths the stomach and enhances the absorpsion of nutrients.

I take both every day. That is my treatment protocol.

The perfect supplements for the Crohnie.

D Bergy
05-17-2007, 11:51 PM   #3
Cara Fusinato
Sarcastic Forum Comedian
 
Join Date: Sep 2006
Ditto with the mangosteen juice concept . . .
05-19-2007, 04:20 AM   #4
Dekar
Senior Member
 
Join Date: Oct 2006
i have mangosteen, probiotic, and turmeric everyday! its good stuff
05-19-2007, 06:38 PM   #5
ruthymg
 
mmm, interesting reading. I love ginger, I must try to eat more.


Ruth
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