Share Facebook
Crohn's Disease Forum » Treatment » Remicade/Infliximab » Remicade and Histoplasmosis


06-14-2011, 07:06 AM   #1
DFreeman
 
DFreeman's Avatar
 
Join Date: Jun 2011
Remicade and Histoplasmosis

Has anyone ever contracted histoplasmosis when using Remicade or any other TNF blocker drug? I was on Remicade for just a couple of months and got very sick. I spent 9 days in the hospital with histo in the lung and liver. 19 days straight with 100 plus fever. Extremely slow recovery time even months afterwards. Just wondering if anyone else had this experience.
06-14-2011, 07:12 AM   #2
Lisa
Adminstrator
 
Lisa's Avatar
 
Join Date: Apr 2010
Location: New York

My Support Groups:
Thankfully no, from my research it is common in the Ohio River Valley area - but can be found pretty much all around the US.....

Are you around birds, caves (bat droppings) or anything like that? The article I found says chicken droppings can contain the fungus...oh joy! and I was going to get chickens this summer!
__________________

30 plus years and counting with UC/Crohn's!
on remicade since 11/05

While my experiences may not be what everyone has had- I feel it is worthwhile to share any and all experiences that may be beneficial to others.
06-14-2011, 10:44 AM   #3
DFreeman
 
DFreeman's Avatar
 
Join Date: Jun 2011
I'm not really around birds. I duck hunt, but that's only in December and January. From what I have learned, there are different strains of it throughout the US. What I had was the Ohio River Valley Fever (histo). I live in Memphis right on the Mississippi River and from what my ID doctor told me, everyone who lives in this part of the country has the spores inside them. However, when my immune system was suppressed on Remicade, it couldn't fight the spores adequately, therefore the symptoms surfaced (fever, coughing). I'm just curious if anyone else has had the same experience.
06-29-2011, 03:51 PM   #4
DFreeman
 
DFreeman's Avatar
 
Join Date: Jun 2011
Well, judging by the lack of response, I'd say I'm the only one who's had this experience.
06-29-2011, 03:55 PM   #5
Lydia
Senior Member
 
Join Date: Mar 2010
I havent really got sick since starting remicade. I get the odd cold, but I get over just as fast as the rest of my family.

I am sorry you had to go through that.
06-29-2011, 04:00 PM   #6
tiloah
Senior Member
 
tiloah's Avatar
 
Join Date: Jun 2010
Location: Seattle, Washington

My Support Groups:
Oof that's awful! Is it a known side effect of Remicade? If not you might want to report your experience to the FDA?

I hope you're feeling better now.
06-30-2011, 07:46 AM   #7
Lisa
Adminstrator
 
Lisa's Avatar
 
Join Date: Apr 2010
Location: New York

My Support Groups:
It isn't really a side effect - just you are more susceptable to the disease.....and it is listed right on the Remicade website/warnings.....

I haven't heard of anyone getting it - and thankfully I haven't been really ill this year (watch me jinx myself!).....strep 2x last spring, nothing really since then....
06-30-2011, 12:57 PM   #8
tiloah
Senior Member
 
tiloah's Avatar
 
Join Date: Jun 2010
Location: Seattle, Washington

My Support Groups:
It isn't really a side effect - just you are more susceptable to the disease.....and it is listed right on the Remicade website/warnings.....

I haven't heard of anyone getting it - and thankfully I haven't been really ill this year (watch me jinx myself!).....strep 2x last spring, nothing really since then....
Oh, well obviously the disease itself would not be a side effect of the medication, but being more susceptible to it surely would be? That's what I meant.

I knew "certain fungal infections" were associated with TNF blockers, just wasn't sure if this was one of 'em.
07-01-2011, 10:24 PM   #9
momasue
New Member
 
Join Date: Jul 2011
I just spent 14 days in the hospital with disseminated histoplasomosis in my abdominal region. 18 months ago I spent 32 days in the hospital with MRSA pneumonia. All related to remicade and a suppressed immune system. I have been told by many doctors to stop remicade as histoplasmosis is not that common in Texas. My ID doctor now has me taking Amphotericin B at home for seven more days then switching to Itraconazole for up to sixth months. I was never informed by my RA doctor regarding this type of fungal infection. I was only told and tested for TB. Remicade is an outstanding drug but I can't continue to pay the price with these infections.
07-06-2011, 12:57 PM   #10
Sadie123
New Member
 
Join Date: Jul 2011
I have a friend who lives in Ohio who developed histoplasmosis.
__________________
Ulcerative Colitis dx 1996
Crohn's Disease dx 6/17/2011

Current treatment: 40mg prednisone (but tapering!), remicade infusions, TPN feedings through picc line

Surgeries: entire colon and rectum removed with the creation of a j pouch july 2008

adhesion removal and ileostomy reversal sept. 2008
09-12-2012, 07:57 PM   #11
california
New Member
 
Join Date: Sep 2012
Location: California
My husband was on Remicade for 10 years. Then he started having undiagnosed intestinal blockages. Doctor after doctor looked at the tests said if if wasn't cancer, they couldn't fathom what it was. Only it didn't test for cancer.

It was histoplasmosis. Multiple surgeries. By the grace of God and good medical care, he returned to work and we hope a more normal life.

Its been over a decade since he was near the Ohio River Valley. Our vet did say he had one cat never out of the San Gabriel Valley who once had it.
01-07-2014, 05:52 PM   #12
ADJ
 
Join Date: Jan 2014
Not sure if anyone is still posting on this thread, but I went through this the Fall 2013. Have had Crohn's for 30 years and been using Remicade for 15 years since it first came out. Worked very well for me and I never had until this past Summer. Deteriorated very fast and it stopped working for Crohn's. Went in for small bowel surgery and they found the histo. Almost died. Found it in my intestines and liver (at least). Being treated for it now still and off the Remicade. Not having any issues with Crohn's since surgery, but experiencing debilitating joint and muscle pain. Also extreme shortness of breath (can't walk up a flight of stairs in my home without being winded). I was running ten miles daily just 2 weeks prior to surgery so not convinced it is tied to histo. Wonder if other have had this problem when they have stopped Remicade after long term use. Also, I live in Indy (ground zero I guess for histo).
01-07-2014, 07:56 PM   #13
ThanksP
Senior Member
 
Join Date: Mar 2010
Location: Costa Rica
This is something that worries me. I live in Costa Rica and we have bats EVERYWHERE. In fact, we had to hang Christmas lights around our house to keep them from roosting in the eaves of our roof. I don't plan on spelunking into any jungle caves any time soon but just having the bats and knowing all the funky issues their guano carries freaks me the heck out. I've been on Remicade since Sept 2011 and have never had an increase in colds or infections. I hope to keep up the good track record. I'm glad that this topic was raised because it reminds me that I need to speak with my Gastro doc about this. It's hard to find a bunch of info on Histoplasmosis down here.
__________________
** Remicade since Sept. 2011
05-11-2016, 03:04 PM   #14
mf15
Senior Member
 
Join Date: Jun 2012
Location: Pennsylvania
I just happened to find this report by accident. Seems crohn's remissions were involved
with itraconazole treatment.
Old Mike
http://onlinelibrary.wiley.com/doi/1...0.04444.x/full
__________________
UC-1980 Still smoke-No Meds. Still have UC.
05-11-2016, 05:14 PM   #15
samtamrox
 
samtamrox's Avatar
 
Join Date: May 2016
Location: st. charles, Missouri
I was just told I have histoplasmosis and that is why they wont let me go on Humira. I have no idea how I got it, other than having a suppressed immune system. I'm in Missouri, my GI said it was pretty common for someone with my issues. JOY. Hope you're doing okay!
07-11-2017, 03:17 PM   #16
Shan6335
 
Join Date: Jul 2017
Location: Illinois
Has anyone ever contracted histoplasmosis when using Remicade or any other TNF blocker drug? I was on Remicade for just a couple of months and got very sick. I spent 9 days in the hospital with histo in the lung and liver. 19 days straight with 100 plus fever. Extremely slow recovery time even months afterwards. Just wondering if anyone else had this experience.
Hello I know this was forever ago, but I was just told I have histoplasmosis and am on remicade. I also was diagnosed with mono. My immune system is pretty much worthless right now. And my doc told me that I might not be able to continue remicade treatment which I don't really care at this point I'm just concerned about what the effects of histoplasmosis will be. Because I was told I have to see a infectious disease doctor. Scary.
Reply

Crohn's Disease Forum » Treatment » Remicade/Infliximab » Remicade and Histoplasmosis
Thread Tools


All times are GMT -5. The time now is 02:22 AM.
Copyright 2006-2017 Crohnsforum.com