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09-19-2011, 01:22 PM   #1
Mr SS
 
Join Date: Sep 2011
Does Azathioprine affect sperm

Hi all

Me and my wife hoping to start a family soon, but I used Azathioprine daily, my doctor said it is dangerous to make family now. Because Azathioprine defects on baby !! and also affect on Organic



For your information, I am a male. I have this Disease about 8 years but I used Azathioprine since 4 years . we are just married before 3 month


I would really appreciate hearing your advise

09-20-2011, 09:39 AM   #2
Lydia
Senior Member
 
Join Date: Mar 2010
I found this.

http://www.ncbi.nlm.nih.gov/pubmed/11677195

Azathioprine treatment and male fertility in inflammatory bowel disease.
Dejaco C, Mittermaier C, Reinisch W, Gasche C, Waldhoer T, Strohmer H, Moser G.
Source

Division of Gastroenterology and Hepatology, Department of Internal Medicine IV, Institute of Tumor Biology, Vienna, Austria.
Abstract
BACKGROUND & AIMS:

Long-term treatment with azathioprine (AZA) is well established in inflammatory bowel disease (IBD). AZA is metabolized to 6-mercaptopurine (6-MP), which interacts in purine metabolism and is therefore considered to have mutagenic potentials. This is the first study to examine the influence of AZA on semen quality.
METHODS:

Semen quality was examined and compared with World Health Organization (WHO) standards regarding sperm density, motility, morphology, ejaculate volume, and total sperm count in 23 IBD patients treated with AZA. In 10 of these patients, a semen sample was assessed before and during AZA treatment; in another 5, semen analysis was performed twice during at least 2 years of AZA therapy.
RESULTS:

In 18 patients treated with 1.5-2 mg/kg AZA daily for at least 3 months but without sulfasalazine, sperm density was 94 +/- 84 Mio/mL (94% within WHO standard), motility was 60% +/- 20% (67% within WHO standard), the proportion of sperm with normal morphology was 44% +/- 21% (67% within WHO standard), ejaculate volume was 3.4 +/- 1.5 mL (89% within WHO standard), and total sperm count was 297 +/- 272 Mio (94% within WHO standard). No changes in semen parameters were noted after 11 +/- 5 months of AZA administration or during long-term treatment (49 +/- 14 months). Sulfasalazine administration in 5 patients was associated with markedly reduced semen morphology. During the study period, 6 patients fathered 7 healthy children.
CONCLUSIONS:

Our data show that AZA does not reduce semen quality and thereby male fertility in IBD.
09-20-2011, 02:10 PM   #3
Mr SS
 
Join Date: Sep 2011
Lydia

I really appreciate for hearing your advise

AZA does not reduce semen quality

i am happy now. we will try to get baby soon
09-20-2011, 02:18 PM   #4
tiloah
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Join Date: Jun 2010
Location: Seattle, Washington

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Methotrexate is pregnancy category X. It is advised that men wait three months after stopping Methotrexate before trying to conceive.

Other than that I don't think IBD drugs have contraindications for men.
09-20-2011, 02:26 PM   #5
Mr SS
 
Join Date: Sep 2011
stopping AZA three month that cause Complications for me ?
09-20-2011, 02:31 PM   #6
tiloah
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Join Date: Jun 2010
Location: Seattle, Washington

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I don't think you need to stop AZA. I think Methotrexate is the only drug you would need to worry about, which you are not on (as far as I can tell).
09-20-2011, 02:33 PM   #7
Mr SS
 
Join Date: Sep 2011
thanks dear Diesanduhr for your action
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