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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Azathioprine and pregnancy


02-20-2012, 01:53 PM   #1
crohns01
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Azathioprine and pregnancy

Does taking Azathioprine affect pregnancy? Does it affect the baby. Do you have to come off the tablets before becoming pregnant?
02-20-2012, 02:39 PM   #2
Angrybird
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Hi there, my GI is fully aware that I want to start trying for a baby in the next few months and has said it is still fine for me to be on the Aza. From what I understand they just monitor you more closely than they would a 'normal' pregnant person.
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Angrybird

DX: Crohns July 2002
Surgery: Ileocecal Resection Sept 2011
Now:Tummy behaving itself and new mummy to baby Nicholas
Current Meds: 6-MP 75mg,B12 injections every 3 months
Previous Meds: Budesonide, Prednisone, Remicade, Pentesa,Hydroxychlorequine,Azathioprine (tried twice) and Methotrexate
02-21-2012, 05:39 PM   #3
SapphireEyes
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During my first pregnancy in 1996, against my doctors wishes, I stopped taking Azathioprine and wound up in the hospital for 5 weeks during my first trimester. My Crohn's colitis flared as it never had before. Instead of being in sporadic spots and my rectal area, it was throughout my entire colon. I almost had to have my colon removed. I had to have TPN and ended up on a ton of other drugs. This was all during my first trimester. Prednisone wasn't working. Cyclosporine wasn't working. Finally, in desperation, I was given Ciproflaxin because it had helped me in the past but there were only 10 documented cases of pregnant women on Cipro at that time. It did help calm things down but it was a very scary time. BTW, that child is now 15 and is healthy She came 4 weeks early and spent 10 days in the NICU.

For my second pregnancy in 2001, I told my doctor that we'd do things his way this time and I took Azathioprine for my entire pregnancy. My Crohn's was completely in remission that entire pregnancy. That child is now 10 and is also healthy She went full term.

My advice is to stay on the Azathioprine if it works for you and is what your doctor is advising. I did have to see a Maternal-Fetal specialist for both pregnancies.
02-21-2012, 08:08 PM   #4
Sbailey
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Location: Dayton, Ohio
I am currently pregnant on Aza. My GI insists I stay on it and the first OB I saw told me not to. My GI had my care transferred to a different OB who is going to co-manage my care with a high risk center.
02-21-2012, 09:19 PM   #5
hawkeye
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Location: New Brunswick

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I was at a seminar last year put on by our local CCFC chapter - one of the topics was CD/UC and pregnancy. The current thinking is Aza is OK during pregnancy as the dose is lower than what a transplant patient would take. They also recommended having a high risk OB if you have Crohn's / UC.
02-21-2012, 10:02 PM   #6
pjmel
 
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I had concerns when I fell pregnant with my second child in 2005 as I was on aza. My GP basically told me that it was a no-no to be pregnant while taking it. However, when I saw my GI he told me that there was new information that showed it was a safe medication to be taking while pregnant. I had lots of attention from the dr's during my pregnancy and in labour, and my son was born with no issues. Glad I didn't listen to my GP!
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Current meds : Imuran, Questran Lite, B12 Injections, Endep
Other alternative treatments : Fish oil, , Mulitvitamin, Vit D.
02-22-2012, 11:40 AM   #7
Rebecca85
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I have spoken to my IBD nurse about this, and she says that while GPs prefer patients to be off all meds, there is a greater risk to the baby if you come off and flare, and it appears that aza is not as bad as they first thought. So her recommendation is to stay on aza.
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Crohn's in the terminal ileum, dxed Jun '10

125mg azathioprine
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02-29-2012, 08:38 PM   #8
dmarrs06
 
Join Date: Feb 2012
Location: El Dorado, Kansas

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Hi Everyone,

I'm very knew to this forum, and what I have seem its giving me hope!! I have a little girl that is almost 2 and I was on remicade during my pregnancy with her and had no problems. However after I had her I had a bad reaction to the remicade and had to stop. I'm now taking imuran and cimzia and I just got my colonoscopy done today and my colon is flared. The point however is I have to give my GI 6 months notice to conceive again and I want to in August and from what I have read most of you took imuran and was fine. (which is kind of a relief) However he said he might want to do steriods during the first trimester as an option and I was wondering if anyone has done that? If so what did you think about it? Would it be better to stay on imuran and cimzia (which my GI is okay with staying on cimzia becuase its a category B) or do the steriods for the first trimester?? I appreciate any feedback! Thanks so much
03-01-2012, 05:16 AM   #9
Sbailey
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I met with my high risk OB today, and she could only find one case of a baby being born preterm with a heart defect and the mother was on Imuran. She said a preterm baby has a higher risk of heart issues, so it may have had nothing to do with the Imuran. She seemed more optimistic of me being on Imuran than the Entecort steroid. The steroids pose a greater risk of the baby having a cleft lip.
03-01-2012, 03:03 PM   #10
dmarrs06
 
Join Date: Feb 2012
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That gives me more clarity on the subject. I go back in a couple weeks to talk more about it and Im leaning more towards staying on imuran than doing the steriods. Thank you so much!!
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