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Crohn's Disease Forum » General IBD Discussion » Crohn's Polls » Have you had your fecal calprotectin or CRP levels tested?


View Poll Results: Have you had your fecal calprotectin or CRP tested?
I have had both fecal calprotectin and CRP tested 76 41.99%
I have had just fecal calprotectin tested 20 11.05%
I have had just CRP tested 66 36.46%
I have not had either tested 19 10.50%
Voters: 181. You may not vote on this poll

 
03-24-2012, 10:58 AM   #1
David
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Have you had your fecal calprotectin or CRP levels tested?

I'm curious how many of you have had your fecal calprotectin or CRP levels tested?

Thanks
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03-24-2012, 12:30 PM   #2
Ihurt
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I have not yet been dx, still going through the motions. But I have had my C-reactive protein testes several times in the last 9 years and it is elevated on and off. I also always have an elevated sed-rate. One doctor told me that having a elevated CRP just means there is inflammation in the body somewhere and that the elevated sed rate can be elevated even if your allergies are bothering you. I was told by a rheumy doctor that I had some sort of autoimmune issus( though they have no clue what!). What is the fecal calprotectin test? Is this some sort of stool test?







I'm curious how many of you have had your fecal calprotectin or CRP levels tested?

Thanks
03-24-2012, 12:57 PM   #3
David
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Correct, it is a stool test. You can read about it here.
03-24-2012, 01:12 PM   #4
Jimena
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In Finland we use this caprotectin test a lot in Crohns. I have just left my stoolsample two days ago and i have the results in two weeks when i have my doctors appointment.
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Severe Crohn's since 2002. Tried every longterm medicine there is, Pentasa, Azamun, Remicade, Humira...
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Colon removal and ileostomy 2015 -> So far so good

And after every stoma surgery, nasty Pyoderma Gangrenosum around my stoma.
03-24-2012, 02:47 PM   #5
Soybean
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I'm on infliximab, and in the uk after a year of being on it you have to show you still have active crohns in order to stay on it. According to my gi they usually do a colonoscopy to check, but he uses the calprotectin test instead. I've got the kit ready to do the test in june (the day before my infliximab is due). I hope it is accurate cos I'm apprehensive of coming off infliximab. He did say that if the test is normal then they go on to do a colonoscopy, but who knows if that actually happens.
03-25-2012, 03:07 AM   #6
monkey
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I've had both, regularly! My old GI swore by CRP results but I've never had that elevated, my new GI actually said for me CRP is bo****ks so they only worry about the fecal calprotectin, I did that the other day, if it's raised i get inflix next My new GI said as far as bloodwork goes, platelet count is a much better indicator than CRPs in CD anyway.... Hmm
03-25-2012, 05:47 AM   #7
Catherine
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Gi will use calprotein to avoid doing colonscopies as often as Sarah level is over 500
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Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

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06-10-2012, 03:05 PM   #8
oneup_twodown
 
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I got mine tested and was shocked when my levels were 755. (my consultant said they were supposed to be below 50)

silly silly bowels
06-10-2012, 04:18 PM   #9
StarGirrrrl
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CRP yes, the stool test no.
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2006. Tummy issues (more IBD than IBS).
2009 joint pain/worsening tummy issues.
CRP 20-36 2006-now. C3/C4 inflammation markers huge,
2014 IDA & low B12.

June 2014 admitted to Hospital 3 nights as emergency transfused 2 units of blood. Dangerous case of anaemia.
Caught by pure chance!
Cause currently unknown but suspected CD.

Waiting on blood & stool results from January.

Hoping to stop anaemia treatment soon & lower B12 daily dose!
06-10-2012, 04:18 PM   #10
Absentminded
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I used to have it regularly when I lived in London.
I think my highest ever was 1370 (I had just been admitted to hospital) , which whilst being somewhat concerned about, I was also quite impressed that it was so ridiculously high!
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Pelvic infection Drainage: April 2013
Ileostomy reversal: February 2013
Ileocecal resection and temp. ileostomy (Say hello to Norman!): Nov 2012
Current Medication: NONE!

Past medications: Humira, Infliximab, Azapthioprine, Asacol, Budesonide, Prednisolone, Flagyl, Cipro, Cholestyramine (Questran), Fortisips.
06-10-2012, 04:48 PM   #11
Norseman
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My caplprotectrin level where over the 3000 mark when I started on meds. Last check it was just under 400. The surgeon says they reckon anything under 200 healthy for a chrons patient. In Normal people it's supposed to be under 50
06-11-2012, 05:39 AM   #12
oneup_twodown
 
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makes sense that is would be higher for someone with crohns...on new meds now so hopefully mine will be within healthy ranges at my next test
10-19-2012, 02:23 AM   #13
ERO
 
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I have had Crohn's for 23 years. Had right hemicolectomy in 1989 and further re-section in 2001 I have kept remarkably well on Olsalazine, Loperimide and colestyramine. Recently had episode of not being able to completely evacuate my rectum so having Calprotect test now as I have ulcer in rectum (shown on earlier colonoscopy 3 years ago) to see if flare-up of Crohn's in that area. I am completely symptom free in all other areas, no pain or sickness or weight loss.
10-19-2012, 08:07 AM   #14
Ihurt
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whats the difference between the calprotectin test and the fecal lactoferrin test? I had the lactoferrin test done just by chance over a year and half ago( before my gut issues started) by a naturopath doc who did this comprehensive stool test at a special lab ( metametrix lab). Mine fecal lactoferrin was elevated 3.7 . When I asked my gastro about this test as I wanted him to do it, he kind of sloughed it off saying it was not very helpful nor reliable. Now I do not know what to think. WHich is better or more reliable, the fecal calprotectin or the lactoferrin one???
10-19-2012, 08:52 AM   #15
David
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Both fecal lactoferrin and fecal calprotectin are inflammatory markers. The difference is fecal lactoferrin is secreted by Leukocytes and fecal calprotectin is secreted by Neutrophils. Both tend to be elevated in people with IBD but my observation is GIs test for fecal calprotectin much more often. I'll let this study speak for the rest:
Background
Research has shown that fecal biomarkers are useful to assess the activity of inflammatory bowel disease (IBD). The aim of the study is: to evaluate the efficacy of the fecal lactoferrin and calprotectin as indicators of inflammatory activity.

Findings
A total of 78 patients presenting inflammatory bowel disease were evaluated. Blood tests, the Crohn's Disease Activity Index (CDAI), Mayo Disease Activity Index (MDAI), and Crohn's Disease Endoscopic Index of Severity (CDEIS) were used for the clinical and endoscopic evaluation. Two tests were performed on the fecal samples, to check the levels of calprotectin and lactoferrin. The performance of these fecal markers for detection of inflammation with reference to endoscopic and histological inflammatory activity was assessed and calculated sensitivity, specificity, accuracy.

A total of 52 patient's samples whose histological evaluations showed inflammation, 49 were lactoferrin-positive, and 40 were calprotectin-positive (p = 0.000). Lactoferrin and calprotectin findings correlated with C-reactive protein in both the CD and UC groups (p = 0.006; p = 0.000), with CDAI values (p = 0.043; 0.010), CDEIS values in DC cases (p = 0,000; 0.000), and with MDAI values in UC cases (p = 0.000).

Conclusion
Fecal lactoferrin and calprotectin are highly sensitive and specific markers for detecting intestinal inflammation. Levels of fecal calprotectin have a proportional correlation to the degree of inflammation of the intestinal mucosa.
10-19-2012, 12:21 PM   #16
hainman
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i got tested a few months back,1st test came back with results of 42,even though i was ill as hell.sent for another test,came back at 8500,specialist nearly fell off his chair.
my next test was 4500.......
10-19-2012, 12:38 PM   #17
Gianni
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Out of curiosity David, how often do you have your levels tested?
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10-19-2012, 12:41 PM   #18
David
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I never have. Right now I'm stuck with a $7,000 deductible and haven't been to a GI in over a year. If I had Crohn's Disease I'd be shelling out the money because it's incredibly important to monitor inflammation levels since they can lead to strictures and other complications. But as I have Lymphocytic Colitis which doesn't lead to stricturing or like complications, I can't justify the expense while money is tight.
10-19-2012, 01:18 PM   #19
Ihurt
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Thanks for that info David. I am just really boggled by my gastro's response. I also talked to another person with crohns who her gastro also did not even order this test and also did not find it of any importance. I just dont get it. I mean I know the hospital I am at is one of the best in my City. My gasrto doc is the head GI there. His specialty is not crohns disease, but I am positive he knows a lot about it. I just dont get why he would not think these tests are of much use. I have researched it and everything I read says it is pretty good at detecting inflammation. I am unsure with the numbers though. I read in one site that anything over a 7.4 is considered high. But then I read somewhere else that anything over 3.1 is considered high.

I had mine done( fecal lactoferrin) and it said that I was at a 3.7 This was done over a year and half ago and at the time I was not having any issues really with my intestines at that point. I am curious where I am now that I am having issues( which is why I am going to ask my doctor to order this test). It just said that mine was high on the lab report. I do not know how they interpet these numbers. Maybe it is different at certain labs, I dont know. I think the gastro docs seems to rely more on blood levels of inflammation, which I have read is less reliable. Are these type stool imflammation markers something that is new and not used very widely yet???
12-06-2012, 06:52 AM   #20
NoelJR
 
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Hello,

I've been in and out of hostpital since March this year with chronic pain in the chest (right side). The tests I've had are:

- exploratory op which found some inflamation of the bowel
- colonoscopy which found nothing
- 2 x CT scans (1 with dye) which found nothing
- white blood cell count which found some inflamation
- numerous blood tests some of which found some inflamtion

After these tests they haven't found out what is causing the pain or given me a definate diagnosis (have had 4 possible maybe's including Crohn's).

Finally I've had 2 fecel calprotectin tests.

The first came back as 278.
The second came back as under 30.

Does anyone know what the numbers mean and causes them to be high/low?

Thanks in advance for any help.

Noel
12-06-2012, 07:03 PM   #21
David
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Hi Noel and welcome to the community. I'm sorry to hear of your struggles

We have a pretty good wiki article about fecal calprotectin located here which should answer many of your questions.
12-09-2012, 02:23 PM   #22
rachomics
 
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My CRP always seems to be normal... it hit the heady heights of 6 a couple of weeks ago and a calprotectin done on the same day came back >6000 :-0
12-09-2012, 03:27 PM   #23
Catherine
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My daughter second test show a rise to 602 and led to further testing (mri) as she was clinical remission.
12-09-2012, 03:39 PM   #24
acheallova
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The only reason my CRP was even tested was at my request. Of course, the diagnosis was not official and the docs ( GI, SURGEON AND DO) were all trying to coordinate to get to the bottom of my issues. Muah- hugs-
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12-10-2012, 08:23 AM   #25
Kip1
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Mine were both ok even when the disease was found to be active as were the blood tests I had. Colonoscopy & Gastroscopy showed active disease so couldn't figure out why it wouldn't show anything with any other tests.
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01-09-2013, 05:25 PM   #26
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Hey everyone I had a colonoscopy in june 2012 and all was clear but december 2012 i had a Fecal Calprotectin test done and my reading was 4162!!! anyone know anything about this sort of thing?
Thanks
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01-09-2013, 08:04 PM   #27
David
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Gazza, it means you likely have active inflammation. Possibly higher up in the small intestines than the colonoscopy could see and more investigation is warranted.
01-09-2013, 09:04 PM   #28
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My Crohn's diagnosis came after multiple autoimmune diagnoses. I started with chronic diarrhea three years ago, and it was labeled as IBS. I tried antispasmodic meds, but they made me dizzy/gave me dry mouth, and that didn't work for me as a teacher. Last February I developed Uveitis followed by alopecia in May (and a previous thyroid diagnosis of Hashimotos). My Rheumatologist suggested retesting on the GI front, and she was totally right. I have had consistently high CRP rates, and my recent colonoscopy revealed ulcers and granulomas in the small intestine. They think this may be the root of "some" of the other issues. I'm wondering if anyone else has autoimmune issues with Crohns?
01-09-2013, 09:33 PM   #29
Clash
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Uveitis is an EIM(extra instestinal manifestation) of Crohn's Disease. I have read several threads on here of members that are dealing with Hashimotos and CD. As for alopecia and CD I did find this article(<---click here), that states there may be a correlation between the two.

You may want to utilize the forum search option at the top of the page to bring up relevant threads, a keyword search of alopecia or hashimotos should bring up the threads posted by other members.
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01-09-2013, 09:33 PM   #30
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My doctor has ordered both of these tests for me, so I'll make sure I find out what the numbers are/what they mean!
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