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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Starting 6-MP and kinda scared!


03-24-2012, 09:02 PM   #1
Colt45m
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Starting 6-MP and kinda scared!

hey guys, i am starting my treatment of 6-MP on wednesday and i am honestly kinda scared of the side effects that it can cause.

Has anybody had some of the liver problems that it can cause like Jaundice and if so how severe?
04-04-2012, 01:07 AM   #2
nate
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Join Date: Apr 2012
me too. let me know how it goes, and i will do the same..starting tomorrow...
04-04-2012, 07:23 AM   #3
Johnnysmom
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Colt, My son started 6mp 7 months ago and I can completely relate to your feelings. They should monitor you very closely with blood work. They will do a blood test before you start to make sure you have an enzyme that will break down they drug in your system. Once you start it they will do another blood test a week or two later that will check liver enzymes, among other things. The 6 mp effected my sons liver so they cut the dose in half and added allopurinol which helps him break it down. He had no physical side effects from this, it just showed up in the blood work. He is doing great now and is in remission. Just make sure your doctor is doing regular blood work. Once you are stable it should be checked every 3 months. I hope everything goes well for you. 6mp has worked great so far for us.
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Dx Oct 11 2011 Crohns disease
Prednisone done 12/30/11
6mp 50mg every day
Allopurinol 50mg -discontinued per new G.I. on 11/01/12
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04-04-2012, 07:44 AM   #4
Irene3
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Hello colt, I started 6mp a week ago, had my first blood test and so far it's a lot better then azathiroprine. I hope it goes well for you, and if their doing regular bloodtests, then you should be fine. Best wishes
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Diagnosed crohns disease 6 yrs/candida
Temorary illeostomy, 70+cm bowel recsection, ulcerated bowel...currently stricturing.
Meds: failed Infliximab, azathiroprine
Currently on long term prednisone,6mp,humira, nizoral, and vit supplements,b12 shots.

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04-06-2012, 09:24 AM   #5
Colt45m
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Thanks guys. Haven't started it yet because my doctor wants me to heal fully from my surgery before I start anything new. But he did discuss all the blood test that you guys mentioned. Thanks again!
04-06-2012, 10:30 AM   #6
Bld
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Join Date: Oct 2011
Hello colt, I started 6mp a week ago, had my first blood test and so far it's a lot better then azathiroprine. I hope it goes well for you, and if their doing regular bloodtests, then you should be fine. Best wishes
Do you mind sharing how you find it better than Aza? I have an appointment with my GI on Friday and he is talking about putting me on Aza so it would be good to be prepared with the options!
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Diganosed with Crohn's in 1996. Flaring since Sept 2011.

Current meds:

6MP = 50mg/day
Pentasa 4 x 1mg/day
Ferrous Sulfate 3 x 200mg/day
Omaprazole
04-06-2012, 02:57 PM   #7
Irene3
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Do you mind sharing how you find it better than Aza? I have an appointment with my GI on Friday and he is talking about putting me on Aza so it would be good to be prepared with the options!
Hi Bid, I personally HATED aza, from the first week. I wasn't throwing up like some, but I had nausea, and within a day of taking it, I just felt 'unwell'. My specialist kept saying it takes 6 months to fully begin to work for the crohns, so after starting and stopping several times, I began to have colitis issues as well as the crohns last year, and after my second hosp visit, I thought id try and stay on it long term.
Within 5 min of being in the sun, I felt like I was burning, like hours with no sunscreen on a 40c day. My crohns didn't improve on it, and during the summer I stopped taking aza, but it takes 6 months to fully leave your system, and even now I don't feel well out in the sun.

I realize 6mp is used for cancer, but so far, I can honestly say I don't feel half as unwell on it, as on aza.

Best wishes...and don't let me put you off, there are many taking aza for crohns, and prob not 200mg, so if you start on 50-100, and feel unwell, you can always stop and try something else. Im really looking foward to humira at the end of this month, though there may be side effects, I would love to not go through 2rolls of toilet paper a day. Lol.

Let me know how you go. Xoxo
04-09-2012, 07:12 PM   #8
ruthyp
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Join Date: Mar 2011
Location: Colchester, United Kingdom
i have been on 6MP for over a year, my hair has thinned but that is the only side affect iv had, sometimes i feel really sick but not sure whether thats just the crohns of the med. It put me in remission!!! the first month was hard, i felt very very sick all of the time, constantly!! but that eased. its worth seeing it through, its tough, but if its the drug for you (like it is for me) and it puts you in remission, then the few weeks of nausea is sooo worth it! good luck!!!
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CD diagnosed '08 however GI recon iv had it since birth.
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Prednisolone 40mg daily
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Tramadol (as much as i can somedays)
04-09-2012, 08:17 PM   #9
Johnnysmom
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My son's G.I. gave us instructions to have him not eat for 2 hours before he takes the 6mp and one hour after he takes it. The only time he had nausea was when we made a mistake and gave it to him an hour after eating. I was also told that it helps with the absorption of the drug. I know not everyone is given these instructions when taking 6mp, and I am not sure why but it might help with nausea.
04-09-2012, 09:47 PM   #10
steelerfan
 
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I have taken 6mp and have not had good effects nor bad effects..knock on wood...still on it..have been for about 8 months.
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Dx Feb 2011
Just finished Prednisone after a year
125mg 6mp,
4g Pentasa 2x a day
Remicade every 8 weeks
Calcium/Vita D supplement

33 I have told you these things, so that in me you may have peace. In this world you will have trouble. But take heart! I have overcome the world.

John 16:33
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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Starting 6-MP and kinda scared!
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