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Crohn's Disease Forum » Books, Multimedia, Research & News » Etiology of inflammatory bowel disease: A unified hypothesis


 
09-09-2016, 11:11 AM   #481
mf15
Senior Member
 
Join Date: Jun 2012
Location: Pennsylvania
I see this thread is still going.
I posted this info back in 2013 or so.
Seems overlooked by the GI community.
Old Mike

yes only 2 people but it worked
https://www.jstage.jst.go.jp/article.../32_4_350/_pdf

BBI
http://www.ncbi.nlm.nih.gov/pubmed/17551835

potato juice
what I find interesting is that

Faecal protease activity in faeces from patients with intestinal resections and healthy infants was found to be significantly higher than in healthy adults.

Brings up the question as to why infants don't get colitis, generally.
Perhaps mucosal anti trypsin activity is quite effective, in infants.

http://www.ncbi.nlm.nih.gov/pubmed/15086363

just to cover another base
Disease associations in alpha-1-antitrypsin deficiency
http://www.ncbi.nlm.nih.gov/pubmed/24176989

another
http://www.ncbi.nlm.nih.gov/pubmed/10807072
__________________
UC-1980 Still smoke-No Meds. Still have UC.
10-20-2016, 04:07 PM   #482
mf15
Senior Member
 
Join Date: Jun 2012
Location: Pennsylvania
I searched this one does not seem to be in the thread.
Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2
From 2002
Old Mike
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850779/

What we have going on here is PAR-2 activation by trypsin and mast cell tryptase which are elevated
in UC. While our alpha-1 antitrypsin is low.

Quercetin is both a mast cell stabilizer/trypsin/tryptase inhibitor.

The problem is you cant get quercetin to the colon unless you I guess overload dosage
with like 50/mg/kg or about 3 grams for a 60 kg person.

But if you take quercitrin it will pass into the colon and breakdown into quercetin.
But you cant get quercitrin as a supplement, except perhaps as dried apple peel will look
at that more. But you can get Rutin which will do the same thing.

Here is the explanation of what is going on,with guercetin,which works in a test tube,but not
in UC models unless you over load to get it to the colon.
http://hera.ugr.es/doi/15772342.pdf

What else is going on of which I will have to track down again if I can find it is that the trypsin
is auto digesting our colon cells,some of the trypsin is also from bacteria .

Will fill out more as I get organized with this info.
Auto digestion.
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3288241/

Protective effect of quercetin not seen at lower doses than 50mg/kg in mice.
http://www.omicsonline.org/proceedin...ons-13963.html

Rutin
/www.ncbi.nlm.nih.gov/pubmed/15652231

might also need high does rutin
/www.ncbi.nlm.nih.gov/pubmed/25281414

Just another thought many of the quercetin supplements now have bromalein, don't think this
is a good idea, you want to get the quercetin into the lower gut, not perhaps into the blood stream.

rutin give extended exposure of quercetin in the gut even may help ileitis
http://www.sciencedirect.com/science...56464614004204

rutin metabolism
/www.drrathresearch.org/images/attachments/education/Phytobiology/Rutin_2015.pdf

I see Briggs beat me to it, but he mentions it as an antioxidant
thepowerofpoop.com/wp/wp-content/uploads/2015/07/IBD-Briggs-July-21-2015-1-1.pdf

My angle is down regulation of protease activity.
Old Mike

Last edited by mf15; 10-21-2016 at 11:19 AM.
11-29-2016, 05:07 PM   #483
gordan
 
Join Date: Nov 2016

My Support Groups:
This is interesting. I wonder what other types of artificial sweeteners are guilty of this?

Regardless, I personally know I'm going to really look into this. Perhaps it's the cause of my issues. Anything new to explore is better than a dead end.
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