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Crohn's Disease Forum » Books, Multimedia, Research & News » MAR and Dr William Chamberlin


06-21-2012, 04:08 AM   #1
Igor_Passau
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MAR and Dr William Chamberlin

Hi,
I send e-mail to the professor and asked him about MAR and CD!

Please see the below all details:

----Original Message-----
From: Chamberlin, William [mailto:[email protected]]
Sent: Thursday, June 14, 2012 4:54 AM
To:XXXX, Igor (UA - Kyiv); [email protected]
Subject: RE: Mycobacterium avium paratuberculosis and Crohn’s disease

Dear Igor,
I attached a recent article (see http://webfile.ru/6008658) supporting the use of properly chosen antibiotics in treating CD. Please read it carefully and then ask further questions. I advise getting your local doctor to treat you with a combination of Clarithromycin 500 mg twice daily, Rifampin 300 mg twice daily and Clofazimine 100 mg twice daily. Try the therapy for at least 3 months before deciding if it works or not.

Good luck,
William Chamberlin

PS: You are welcome to come to Billings, Montana where I will be able to treat you.
06-21-2012, 04:14 AM   #2
Igor_Passau
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about article on the http://webfile.ru/6008658! you have wait 30 second and then choose
- "Скачать файл"
06-21-2012, 08:51 AM   #3
Igor_Passau
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Table 2. Summary of outcomes of anti-Mycobacterium avium paratuberculosis therapies in Crohn’s disease.

Antibiotics used:
  • Rifabutin,
  • clarithromycin and
  • clofazimine (AMAT)

Duration - 16–104 mouths

Results
ITT ana lysis:
Remission sustained in 66 out of 102 (65.7%) patients on AMAT
vs 55 out of 111 (49.5%) on placebo (p < 0.02) at 16 weeks

Effects of AMAT after 16 weeks:
At 52 weeks: remission sustained in 41 out of 102 (40%)
patients vs 24 out of 111 (21.6%), p < 0.005
At 104 weeks: remission sustained in 31 out of 102 (30%)
patients vs 16 out of 111(14%), p < 0.008
At 152 weeks: remission sustained in 14 out of 102 (13%)
patients vs 10 out of 111 (13%), p < NS

Patients:
213 randomized
Active
(n = 102)
Placebo
(n = 111)
91 were
withdrawn
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