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Crohn's Disease Forum » Books, Multimedia, Research & News » Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitu


07-24-2012, 12:04 AM   #1
kiny
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Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitu

This is something I have never heard of, does anyone know what Rebamipide is?



Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

http://www.wjgnet.com/1007-9327/pdf/v17/i33/3802.pdf

Tomohisa Takagi, Yuji Naito, Kazuhiko Uchiyama, Toshimitsu Okuda, Katsura Mizushima, Takahiro Suzuki, Osamu Handa, Takeshi Ishikawa, Nobuaki Yagi, Satoshi Kokura, Hiroshi Ichikawa, and Toshikazu Yoshikawa

Abstract

AIM
: To investigate the efficacy of rebamipide in a rat model of colitis and restitution of intestinal epithelial cells in vitro.

METHODS: Acute colitis was induced with trinitrobenzene sulfonic acid (TNBS) in male Wistar rats. Rats received intrarectal rebamipide treatment daily starting on day 7 and were sacrificed on day 14 after TNBS administration. The distal colon was removed to evaluate the various parameters of inflammation. Moreover, wound healing assays were used to determine the enhanced restitution of rat intestinal epithelial (RIE) cells treated with rebamipide.

RESULTS: Intracolonic administration of rebamipide accelerated TNBS-induced ulcer healing. Increases in the wet weight of the colon after TNBS administration were significantly inhibited by rebamipide. The wound assay revealed that rebamipide enhanced the migration of RIE cells through phosphorylation of extracellular signal-regulated kinase (ERK) and activation of Rho kinase.

CONCLUSION: Rebamipide enema healed intestinal injury by enhancing restitution of RIE cells, via ERK activation. Rebamipide might be a novel therapeutic approach for inflammatory bowel disease.
Keywords: Rebamipide, Experimental colitis, Intestinal epithelial cells, Extracellular signal-regulated kinase, Rho kinase
07-24-2012, 03:58 PM   #2
Igor_Passau
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Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction.
http://www.ncbi.nlm.nih.gov/pubmed/21373269
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