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Crohn's Disease Forum » Books, Multimedia, Research & News » MAP associated with italian Type 1 diabetes patients.


07-31-2012, 12:15 PM   #1
kiny
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MAP associated with italian Type 1 diabetes patients.

I wonder how long it will be before the media pulls the lid off this thing.


http://www.ncbi.nlm.nih.gov/pubmed/22844325

2012; july

Pediatric Diabetology Unit, Policlinico di Tor Vergata, University of Rome Tor Vergata, 00133 Rome, Italy.

Mycobacterium avium subsp. paratuberculosis in an Italian Cohort of Type 1 Diabetes Pediatric Patients.

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease in ruminants. Recent studies have linked MAP to type 1 diabetes (T1D) in the Sardinian population. The aim of this study was to investigate the prevalence of MAP infection in a T1D cohort from continental Italy compared with healthy control subjects. 247 T1D subjects and 110 healthy controls were tested for the presence of MAP. MAP DNA was detected using IS900-specific polymerase chain reaction (PCR). The presence of antibodies towards a MAP antigen, heparin binding hemoagglutinin (HBHA), was detected by ELISA. We demonstrated a higher MAP DNA prevalence in plasma samples from T1D patients and a stronger immune response towards MAP HBHA, compared with healthy control subjects. Moreover, in the recent onset patients, we observed an association between anti-MAP antibodies and HLA DQ2 (DQA1 0201/DQB1 0202). These findings taken together support the hypothesis of MAP as an environmental risk factor for the development of T1D in genetically predisposed subjects, probably involving a mechanism of molecular mimicry between MAP antigens and pancreatic islet β-cells.
07-31-2012, 12:22 PM   #2
SarahD
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I've only read the abstract but find this really interesting - I hadn't realised that MAP was implicated in more than just Crohns (and Johnes) disease.

Thanks Kiny, I enjoy reading the many articles that you post!
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Symptoms from the age of 12. Mis-diagnosed with UC at the age of 13, and later diagnosed with Crohn's in January 2012 at 24 years old. Disease mainly in terminal ileum.


Current meds:
Azathioprine, Allopurinol, Calcichew D3-Forte, Fortijuice, Alendronic acid, Ranitidine

Previous meds:
Augmentin, Doxycycline, Lansoprazole, Asacol, Pentasa, Prednisolone, Entocort, Cipro, Flagyl, Elemental Extra 028
07-31-2012, 01:31 PM   #3
D Bergy
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I find this quite interesting.

I eliminated my own Psoriasis by specifically targeting the MAP bacteria using an experimental treatment. I am going to put this study out to others that work with the same type treatment, and see if anyone with Type 1 Diabetes can help their condition.

Should learn something, if anyone tries it out.

Thanks for finding and sharing this interesting research.

Dan
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