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Crohn's Disease Forum » Books, Multimedia, Research & News » A case of rapidly progressive IgA nephropathy in a patient with exacerbation of Crohn


08-06-2012, 01:45 PM   #1
Igor_Passau
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A case of rapidly progressive IgA nephropathy in a patient with exacerbation of Crohn

Abstract (provisional)
Background
IgA nephropathy has been reported as a renal involvement in Crohn's disease. Crescentic IgA nephropathy, which accounts for fewer than 5% of cases of IgA nephropathy, has a poorer prognosis than other forms of crescentic glomerulonephritis. We recently experienced a case of rapidly progressive IgA nephropathy concurrent with exacerbation of Crohn's disease.

Case presentation
An 18-year-old male diagnosed with Crohn's disease underwent a hemicolectomy 2 years previously. He had maintained a state of Crohn's disease remission with 5-aminosalicylic acid treatment. Four months prior to referral to the nephrology clinic, he experienced non-bloody diarrhea. He simultaneously developed proteinuria and microscopic hematuria with deterioration of renal function. Based on renal biopsy findings, the patient was diagnosed with crescentic IgA nephropathy. Immunostaining for interkeukin-17 in renal tissue and previous exacerbated colonic ulcers was positive. Steroid pulse therapy was administered, followed by high-dose glucocorticoid and oral cyclophosphamide therapy. The patient's renal function recovered and his gastrointestinal symptoms were alleviated.

Conclusions
We report a case of crescentic IgA nephropathy presenting with exacerbation of Crohn's disease, and present a review of the literature focusing on the pathophysiologic relationship between these two conditions.

http://www.biomedcentral.com/1471-2369/13/84/abstract
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