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08-15-2012, 07:06 AM   #1
Moe.
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TH17: Judgement Day

Hi guys sorry if this is posted.
But might explain LDN, vitamin D have an effect.

TH17: Judgement Day
Filed under autoimmune, crohns, diabetes, drugs, IBS, immune modulator, lupus, MS, Psoriasis, rheumatoid arthritis, Treatment
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Now I know TH17 sounds big & scary. T1, T2, and T1000 all scare the crap out of me. Something about big biceps playing classical violin just screams world domination:

Terminator Playing Violin

But just know that TH17 may potentially change how autoimmune diseases are treated forever. Also, know that big pharma knows this: Merck is spending $300 million to get its hands on proprietary meds targeting TH17. I just love waking up to news with big pharma screaming “YOU SHALL NOT PASS until it’s FDA approved in 10 years” on a promising target for autoimmune treatment which can be treated with a natural herb.

So far, TH17 has been shown to be elevated in the following: RA, SLE, MS, Psoriasis, Crohn’s, IBS, type 1 diabetes, eczema. And that’s only what’s been researched so far. I know what you’re probably saying: there have probably been 100s of abnormal levels of biomarkers that correlate with autoimmune disease, but that doesn’t mean treating it helps. What makes this different? Check this out:

“halofuginone from hydrangea root ‘prevents the development of Th17 cells in both mice and humans….reduces disease pathology in a mouse model of autoimmunity.” – http://www.eurekalert.org/pub_releas...-anl060109.php (hat tip to Danny for this link)

See part in bold. At least in mice, stopping th17 actually reduces autoimmune disease. The next step is seeing if this applies to humans, but preliminary trials show it may be the case:

“RA, psoriasis, and uveitis…patients treated with (anti-IL-17 antibody) show a similar reduction in symptoms to those treated with …Remicade)” - http://www.hindawi.com/journals/iji/2012/819467/

Now many of you are probably on steroids such as prednisone for alleviating your autoimmune symptoms. For many of you, this makes life bearable, but you’re probably well-aware of the gnarly side effects & potentially life-threatening dangers of suppressing your entire immune system. The holy grail of autoimmune treatment is targeting the out-of-whack part of the immune system, without causing universal immune suppression. That’s where TH17 targeting medication may really shine:

” ‘(halofuginone) is really the first description of a small molecule that interferes with autoimmune pathology but is not a general immune suppressant,’ says Mark Sundrud, PhD, of the PCMM/IDI, the study’s first author.” - http://www.eurekalert.org/pub_releas...-anl060109.php

Hey Halofuginone, I think you got that magic in you. Does that mean I have to wait 10 years to get that magic in me?

Well, not exactly. Let’s discuss this and a number of other OTC and prescription meds that have been clinically shown to lower TH17:

1) Chang Shan (contains halofuginone) is one of the fundamental TCM herbs, which means it might be available at your local TCM shop. Note: According to this merchant, Hydragea Root (Tu Chang Shan) is not the same as Chang Shan (Dichroa Root), and only the latter has organic halofuginone - http://changshansupplement.com/hydra...not-same-thing

1) Etanercept (Enbrel), a highly successful Psoriasis med, may lower TH17 - http://scienceline.org/2008/06/healt...-autoimmunity/

2) Digoxin (digitalis) a heart medication, suppresses th17 “without affecting differentiation of other T cell” - http://www.nature.com/nature/journal...ture09978.html

3) Low Dose Naltrexone (LDN), an immune modulator discussed in our last blog The Most Effective Medication For Autoimmune Illness. Based on this action chart by Aristo Vojdani, Ph.D, LDN downregulates TH17.
http://www.cpnhelp.org/copy_ldn_action_chart_a_v

4) Vitamin D (often found to be low in autoimmune diseases) suppresses Th17 - http://www.jbc.org/content/285/50/38751.full.pdf

5) Lactobacillus gasseri (OTC) suppresses Th17 pro-inflammatory response in a mouse model of allergic asthma - http://www.ncbi.nlm.nih.gov/pubmed/21996276 OTC Lactobacillus gasseri available: http://www.iherb.com/Search?kw=gasseri+&x=0&y=0

6) N-Acetylglucosamine (OTC) Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses - http://grtc.ucsd.edu/essentials_2012...keD-GlcNAc.pdf OTC N-Acetylglucosamine available http://www.iherb.com/Search?kw=Acety...samine&x=0&y=0

DISCLAIMER: The information in this blog is not advice, and should not be treated as such. You must not rely on the information on this website as an alternative to medical advice from your doctor or other professional healthcare provider.


http://blog.healclick.com/th17-key-t...mmune-illness/
08-15-2012, 09:37 AM   #2
CLynn
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Join Date: Feb 2012
Location: Missouri
Thanks for this, Moe! Do you mind me asking if you are currently on any meds?
__________________
Cheryl
Diagnosed:1988
Previous meds: Sulfadiazine, Flagyl, Prednisone, Imuran, Pentasa, Asacol
Surgeries: re-section 2004
Currently taking: B-12 injections every 2 weeks, multi vitamin/mineral, fish oil (1000 mg), D3 (5000 mg)

Also lucky enough to have psoriasis as well.
08-18-2012, 05:33 AM   #3
Moe.
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Join Date: Aug 2012
Location: sydney, New South Wales, Australia
Hi there Clynn
Sorry for late reply. Been packed with work.
Currently on prednisone and 5-ASA.
Diagnosed recently
08-18-2012, 05:49 AM   #4
nogutsnoglory
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Wow thanks for this interesting research. Do you know how much of this stuff one would need to take?
08-19-2012, 05:05 AM   #5
Moe.
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Join Date: Aug 2012
Location: sydney, New South Wales, Australia
Hi there
Sorry but I really have no clue. What I do know is they have tested LDN and so have people here with 4.5mg dosages, and for some it works. So its best asking them.

I do not think anyone knows exactly how crohn's disease works. But to put it in general term. Its like a software virus that attacks one specific thing that unleashes a series of unfortunate events. Its likely to be one culprit. In my family line there are only 3 of us with crohn's. Genetics they say? WOW the funny part of it is that I am a family in the hundreds(still alive) no kidding. And we are the only three who have ever had it in the families history.
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