Share Facebook
Crohn's Disease Forum » Books, Multimedia, Research & News » The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment


09-05-2012, 01:13 AM   #1
Igor_Passau
Forum Monitor
 
Igor_Passau's Avatar
 
Join Date: Aug 2010
Location: Kyiv, Ukraine
The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment

Mammalian Nod2 is an intracellular protein that is implicated in the innate immune response to the bacterial cell wall and is associated with the development of Crohn?s disease, Blau syndrome, and gastrointestinal cancers. Nod2 is required for an immune response to muramyl dipeptide (MDP), an immunostimulatory fragment of bacterial cell wall, but it is not known whether MDP binds directly to Nod2. We report the expression and purification of human Nod2 from insect cells. Using novel MDP self-assembled monolayers (SAMs), we provide the first biochemical evidence for a direct, high-affinity interaction between Nod2 and MDP.
http://www.citeulike.org/user/GrayLab/article/11187619
09-05-2012, 01:23 AM   #2
kiny
Senior Member
 
kiny's Avatar
 
Join Date: Apr 2011
thanks Igor
09-05-2012, 01:30 AM   #3
kiny
Senior Member
 
kiny's Avatar
 
Join Date: Apr 2011


09-05-2012, 01:32 AM   #4
kiny
Senior Member
 
kiny's Avatar
 
Join Date: Apr 2011
well hm, nm
Reply

Crohn's Disease Forum » Books, Multimedia, Research & News » The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment
Thread Tools


All times are GMT -5. The time now is 06:15 PM.
Copyright 2006-2017 Crohnsforum.com