My husband started taking this medicine almost a week now for highly active crohns, after a colonoscopy and ct scan with ulcers. His specialist told him this type of medicine would be the only kind strong enough. (He was taking Asacol) prescribed by our family physician. Anyhoo, now he is telling me about his terrible body aches. He says they are even worse than when he was on No meds. Is this normal? Will they ease up? I'm really, really trying to sway him away from the BC powders, which is what he was dependant on when we had no insurance and no meds. He had quit taking them after he started treatment, until now. I HATE those things. Imuran, He is taking 250 mg once a day- thats 5-50mgs at once. He is 230 lbs. Is this a large starting dose? Oh, and his urine is neon yellow, which im thinking is normal? Any advice?