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Crohn's Disease Forum » Treatment » Low Dose Naltrexone » Phase III Low Dose Naltrexone Trial Possible


01-08-2013, 12:49 PM   #1
David
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Phase III Low Dose Naltrexone Trial Possible

TNI BioTech, Inc. Acquires the Exclusive Rights to Low Dose Naltrexone and Other Opioid Antagonists for the Treatment of Inflammatory and Ulcerative Diseases of the Bowel

Naltrexone in low dose has been well tolerated in almost all patients, and it showed significantly greater treatment efficacy than the control group in both trials. TNI BioTech is now planning to meet soon with the FDA to design and implement pivotal phase III trial(s) for treatment for patients with Crohn's disease using naltrexone in low dose. A platform immunomodulatory technology, naltrexone in low dose also is expected to be clinically tested for treatment of other immune-mediated or immune-deficient diseases, for which the company has previously acquired additional patents.
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01-08-2013, 01:32 PM   #2
JDTM
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Hi, I'm Jesse!

Current meds:
Lialda (4.8g)
fluoxetine (40mg)
naltrexone (4.5mg)

Previous meds:
Dexilant (too pricey!), Xifaxan (short course), budesonide (tapered off), Pentasa (had to switch in January 2016), omeprazole

Supplements:
multivitamin
2000IU vitamin D-3

Diagnosis:
gastritis & duodenal ulcers, August 2011
Mild Crohn's in terminal ileum, February 2012
5cm of narrowing w/ no signs of active inflammation, May 2014
01-08-2013, 01:36 PM   #3
ctrl z
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01-08-2013, 05:17 PM   #4
Jmrogers4
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Oh how I hope this means a phase III trial, although Jack is taking it and seems great I still have that little doubt in the back of my mind what if there is something we don't know....
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Jacqui

Mom to Jack (18) dx Crohn's 2/2010
Vitamin D -2000mg
Remicade - started 1/9/14; 7.5ml/kg every 6 weeks
Centrum for Him teen multivitamin
Past meds: Imuran/Azathioprine; allopurinol; methotrexate; LDN; Prednisone; Apriso; Pentasa; EEN

Husband dx Crohn's 3/1993
currently none due to liver issues
11-08-2015, 09:17 PM   #5
earthshine
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Oh how I hope this means a phase III trial, although Jack is taking it and seems great I still have that little doubt in the back of my mind what if there is something we don't know....
Wonder if any results are available? Only thing I saw on their website for LDN referred to a study in Nigeria but unrelated to crohns
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Crohn's Disease Forum » Treatment » Low Dose Naltrexone » Phase III Low Dose Naltrexone Trial Possible
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