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Crohn's Disease Forum » Books, Multimedia, Research & News » Linoleic acid possibly contributing to IBD


02-16-2013, 01:01 PM   #1
mf15
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Linoleic acid possibly contributing to IBD

I may be wrong but really believe that possibly a main cause of IBD is excess linoleic acid in the diet.
I have a few threads on this,but here is some really important info.
Old Mike
I also want to point out what is going on with our meat supply,it seems that there has been a major shift,to higher linoleic acid content. Not sure when this might have occured. But here is some lard data. I really suspect if you eat meat only eat grass fed,but you still cannot be sure they are not being fed corn/soybean at some point.

This probably also applies to beef tallow,chickens,turkeys.

But if you stop eating highly polyunsaturated veggie oils,and eat regular meat, you still cannot get away from linoleic acid. The other way around it is wild cought fish,farmed fish is no good.

THIS IS A DISASTER.

Old Mike

This is data from mice experimental fat diets.

http://blog.cholesterol-and-health.c...ased-high.html



to the right click on lard.

http://www.researchdiets.com/opensou...ed-ingredients



here is some data comparing the old data base to new lard

http://www.westonaprice.org/blogs/cm...and-a-coconut/

Linoleic content USA body fat since 1960,love to find earlier data.
http://perfecthealthdiet.com/2012/02...h-pork-part-2/

1943 data
http://www.jbc.org/content/151/2/427.full.pdf

1960
http://www.ncbi.nlm.nih.gov/pmc/arti...01003-0098.pdf

even the above data not early enough,prior to this analytical techniques
poor. Food supply contaminated with linoleic earlier.

some historical points
http://www.dietheartpublishing.com/diet-heart-timeline

immune inhibition
http://www.ncbi.nlm.nih.gov/pmc/arti...v075p00129.pdf

transfats
http://www.ncbi.nlm.nih.gov/pubmed/1636272

here is an odd but forgotten paper on crohn's
http://pmj.bmj.com/content/67/789/666.full.pdf
another
http://www.meduniwien.ac.at/innere3/...el_IBD2007.pdf

http://www.direct-ms.org/pdf/Molecul...0molmicadd.pdf

n6 PUFA
http://www.hindawi.com/journals/jnume/2012/539426/

Last edited by mf15; 02-17-2013 at 10:11 AM.
02-18-2013, 12:30 PM   #2
David
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Thoughts on this Mike?
March 16, 2012

BLACKSBURG, Va., March 16, 2012 – The Nutritional Immunology and Molecular Medicine Laboratory (NIMML) research team at Virginia Tech has discovered important new information on the efficacy of conjugated linoleic acid (CLA) in treating Crohn’s disease, a form of inflammatory bowel disease (IBD). CLA is a naturally occurring fatty acid found in meat and dairy products known for its anti-cancer and immune modulatory properties.

In collaboration with the Division of Gastroenterology and Hepathology at University of North Carolina School of Medicine and the Wake Forest Medical Center, researchers found that Crohn’s patients who took supplementary CLA showed noticeable improvement. “In our recent open label study of CLA as a supplement in study subjects with mild to moderate CD there was a marked improvement in disease activity and quality of life in 50% of the subjects. CLA was well tolerated by all of the study subjects. These findings are very encouraging and will need to be verified in a randomized controlled trial,” said Dr. Kim L. Isaacs, Professor of Gastroenterology at the University of North Carolina at Chapel Hill.

The two main manifestations of IBD—Crohn’s and ulcerative colitis—afflict over 1.4 million people in the United States. Symptoms include abdominal cramping, fever, fatigue, loss of appetite, skin and mouth ulcers, and diarrhea or constipation. In addition, the risk of developing colorectal cancer increases by about one percent yearly in IBD patients. Currently, there is no cure for Crohn’s disease and the exact causes of it aren’t fully understood.

CLA affords those afflicted with mild to moderate IBD an effective treatment without the unwanted side effects of many synthetic drugs. “Furthermore, we have demonstrated that probiotic bacteria can produce CLA locally and suppress colitis. Therefore, CLA can be administered directly in capsules or indirectly through CLA-producing probiotic bacteria,” said Dr. Raquel Hontecillas, an Assistant Professor of Immunology at NIMML.

*snip*
Continue reading...
02-18-2013, 12:53 PM   #3
mf15
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Hi David: Yes I know about CLA,have a bottle at home which I have not touched as of yet it has been at least 6 months,the material you can buy is a liver toxin,mixed iosmers. I will have to look more into its toxicity if there is more info than I found 6 months ago. CLA is not the linoleic I am talking about, what I refer to is N6 PUFA.
Please take a close look at the charts in my OP,what really scares me is that the composition of human fat has changed over time due to all the linoleic acid in the diet,this also means all the membranes in immune cells,and the composition of lipids throughout the body are different than they were 100 years ago. This change in the N6/N3/N9 ratio also leads to excess inflammatory leukotrienes.
Old Mike
02-18-2013, 12:57 PM   #4
David
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Ah, my bad. I didn't realize there was a difference.

I do agree that the n3-n6 fatty acid ratio we subject our bodies to these days causes a wealth of health problems. It is something I have been working hard to correct. We talked about it here quite a bit.
02-18-2013, 01:09 PM   #5
mf15
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This might help you to see the difference in fatty acid types.
Old Mike
http://en.wikipedia.org/wiki/Polyunsaturated_fatty_acid
02-18-2013, 01:14 PM   #6
David
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Thanks Mike!

Another of the N6 fatty acids I've looked at heavily is arachidonic acid (check that out) which I got into after reading this article. It was a big part of the reason I went to grass fed meats and don't buy eggs anymore, even organic eggs. All our animals are corn fed when they shouldn't be AND we get crammed full of all kinds of corn products on a regular basis. I feel cutting out pretty much all corn and corn products/corn fed meats has helped my healing a lot.
04-27-2013, 02:17 PM   #7
mreyn
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I just found this thread as I was looking at adding cla to my sons supplements after reading it can be very beneficial for crohns. So.. is it best not to supplement with cla? What about omega 3's , flaxseed oil , alpha linolenic acid, oleic acid ?

I had read this about the essential fatty acids from a drs site and I know my sons diet doesn't include enough so I'm confused what to do. He's also on Remicade, if that matters:

Essential fatty acids are not hormones, although they are probably just as powerful. Without them you literally die.
04-27-2013, 06:28 PM   #8
mf15
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CLA has some liver toxicity,best to stay away from it,this is of course the stuff you can buy with the mixed isomers.
Omega 3's are good, olive oil ok,flax probably ok coconut ok
Then again I believe that excess sugar/fructose and fried,baked.grilled.broiled foods are a problem,but that is me.
Old Mike
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