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Crohn's Disease Forum » Books, Multimedia, Research & News » A new paradigm in ulcerative colitis: Regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance.


02-23-2013, 11:44 PM   #1
kiny
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A new paradigm in ulcerative colitis: Regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance.

http://www.ncbi.nlm.nih.gov/pubmed/23280396

A new paradigm in ulcerative colitis: Regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance.

Hiroyuki Hanaia, Takayuki Iidaa, Kentaro Ikeyaa, Jinrou Abea, Yasuhiko Maruyamab, Teruyuki Shimurab, Ken Sugimotoc, Fumitoshi Watanabea

Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan

2013 Jun

Leukocytapheresis (LCAP) appears to remove or inactivate inflammatory cells and to reset immunological responses, resulting to cure responders of ulcerative colitis (UC). The changes of T cell subsets were investigated in UC patients treated with LCAP. Levels of T cell subsets in peripheral blood before and after LCAP were analysed by flow cytometric analysis. Of 20 UC patients, 13 (65%) achieved remission and 2 (10%) showed the improvement of UC symptoms. Ratios of some T cell subtypes such as regulatory T (Treg) cells and memory T cells to CD4(+) T cells changed significantly only in responders. Especially, ratio of resting Treg/CD4(+) T cells was significantly increased after the first LCAP session, and then one of activated Treg/CD4(+) T cells was increased after 2 week. This may lead to the development of a new UC paradigm in which an imbalance in Treg cell subsets triggers the onset and/or exacerbation of UC.
02-24-2013, 12:29 AM   #2
kiny
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I made a whole post about Th and Treg but deleted it, since it's easier to just read about them I think.
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Crohn's Disease Forum » Books, Multimedia, Research & News » A new paradigm in ulcerative colitis: Regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance.
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