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Crohn's Disease Forum » Treatment » 5-ASA/Mesalamine » Asacol discontinued


 
06-26-2013, 12:12 PM   #121
Kathyhamilton
 
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To those of you now taking Delzicol, are you taking 3 twice a day or 2 three times a day?
07-06-2013, 06:24 PM   #122
cha
 
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Went to refill my rx and received the replacement Delzicol. I've been taking asacol for 18 years. learned more on this forum than at my drug store. it's a holiday and I couldn't get my Dr. Thanks everyone!
07-09-2013, 08:10 PM   #123
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To those of you now taking Delzicol, are you taking 3 twice a day or 2 three times a day?
While in remission I take 3, twice a day (6). When I get a flare (not very often) I will up the dosage to 3, three times a day (9) for a few weeks. It works for me. This is the same as I did for several years on Asacol.

Having said that, I think taking 2 three times a day is probably preferred. It should keep the medicine in your system longer if taken every 8 hours instead of every 12 hours.
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07-31-2013, 01:14 PM   #124
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I've been taking medication for my Ulcerative Colitis since 2006. I had no insurance and the medication is crazy expensive. I went online and found a generic through a Canadian pharmacy, as someone previously mentioned. I'd been using those for 3+ years and never had a problem. Buying in large amounts is cheaper too. I could get 1,000 (400) tablets for $389 + $10 shipping and that would last me about 5 1/2 months. Buying one month of Asacol here is $400+.
09-04-2013, 03:08 PM   #125
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I'm still able to get my Ascaol 400mg x8 a day... wonder if it's different for us across the pond here in the UK! I'll mention this to my consultant. These Delzicol meds don't sound that nice!
09-12-2013, 02:37 AM   #126
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Anybody know...are the various forms of oral mesalamine equivalent? The only other mesalamine my insurance will cover is Apriso. Seems like they're all designed to dissolve in the ileum.
09-18-2013, 04:33 PM   #127
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You're right that it's expensive, kh216! With insurance I pay $75 a month for Asacol. Without insurance, I believe it'd be over $500 (going by memory, don't have the info in front of me). I just looked it up, and with my insurance I'd also be paying $75 per month if I switched to Delzicol. It looks like it'd be the same cost for Asacol HD too. So at least I won't be paying any more, but I sure would like to pay less as $75 each month is not cheap. (I also take Nexium, Ranitidine, and Amitriptyline - and generic Zofran as needed - so with those added in I pay over $100 each month just for prescriptions).
Hi! I am a patient advocate for a patient who has Crohn's disease in his small intestine. The Asacol was working so well for him and now the 800mg is not covered by his insurance and he is paying out of pocket about $400 a month. Can someone give me some insight as to what insurances are covering the Asacol so I can assist this patient?
09-20-2013, 01:38 PM   #128
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I commented in another post, but I have Aetna and my copay is $60 for my Asacol.
09-22-2013, 08:45 PM   #129
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Hi! I am a patient advocate for a patient who has Crohn's disease in his small intestine. The Asacol was working so well for him and now the 800mg is not covered by his insurance and he is paying out of pocket about $400 a month. Can someone give me some insight as to what insurances are covering the Asacol so I can assist this patient?
I have Health Net insurance and pay $30 at Walmart for my Asacol 800 HD prescription, take 2 a day and am still doing very well on it.
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12-07-2013, 10:44 PM   #130
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I was on Asacol for yrs until it was replaced with Lialda. I started Lialda in May/June. Around July/August my hands, feet, joints etc. were so swollen & sore so I went to a specialist (thought maybe I had Arthritis). The Dr. did lots of blood work & xrays found nothing told me to go for PT. August I started getting a rash on my legs thought maybe I had sun poisoning ( I had been in Aruba for 3 wks). By October it was getting worse burning, itchy and now on my stomach, upper legs & back. I finally went to a Dermatologist was told I had Eczema and was given a Steroid cream. It did help with the burning but the rash is still there.
This past Friday I had a headache and another scratchy throat ( the 4th since Sept). Since I work at a school I thought nothing of it until one of the women that I work with said how long ago did you start that new medicine? So I googled side effects for Lialda. BINGO everything that I have been dealing with was listed as a side effect. So I called my GI and he called in a prescription for Asacol HD DR 800 MG tablets!! My original Asacol 400 mg I was taken 4 pills a day that's 1,600 mg. This new prescription Asacol HD 800 mg he has me taking 3 tablets 2 x a day that's 4,800. The amount doesn't add up to what I originally taking! I wonder why?
01-01-2014, 10:30 PM   #131
jrogers
 
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So I'm surprised that no one (but me, I guess) has looked inside the Delzicol capsules. It's an Asacol caplet in a capsule. The capsules protect the patent, not the medicine.

Asacol, Asacol HD and Delizcol are all manufactured by Warner Chilcot De. Gmbh. (Since I am new to this list, I can't post the URLs of the regulatory sheets, but you can find them by searching for asacol-info.pdf, AsacolHDPrescribingInfo.pdf and pi_delzicol.pdf) While the Asacol variants are licensed from Medeva Pharma Suisse AG and the Delzicol is not, that seems to only be because Medeva owns the trademark on Asacol. Note that the Delzicol regulatory sheet explicitly states that the clinical studies it cites were conducted with "mesalamine delayed-release tablets" (that would be Asacol) and that Delzicol is bioequivalent. I would guess so.

Up until the end of 2010 (at least) Asacol was manufactured by Procter and Gamble under license from the same Swiss company. Then for a while it was manufactured by a smaller Ohio company. Now it's imported. P&G likely got out when the patent was about to run out.

The only good things I can say about Asacol is that it works and, unlike other mesalamine drugs, doesn't make me sick. So I live with Warner Chilcot just as I live with UC.

As for dosage, I've had prescriptions both for 2x3 Asacol tablets a day and 3x2 Asacol tablets. I don't even know what the Delzicol prescription actually says. I use 2x3 because it's more convenient and works.

May you all have a flare-free New Year.
01-01-2014, 10:48 PM   #132
jrogers
 
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A follow-up after reading some more of the regulatory sheets. It appears that the non-bioequivalence between Asacol and AsacolHD is because less of the mesalamine in the AsacolHD shows up in the blood (36% lower maximum blood concentrations with 1x800mg HD vs. 2x400mg regular). This is probably a good thing, but whether it is or is not depends on how the mesalamine works and that no one knows. (We know only that it does. Good magic is magic that works.)

So is the HD phthalate free? I rather doubt the Delzicol is. But none of the data sheets list out the excipients. Maybe the Ohio/Germany move was to avoid falling astray of the FDA recommendation.
01-01-2014, 11:29 PM   #133
2thFairy
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So I'm surprised that no one (but me, I guess) has looked inside the Delzicol capsules. It's an Asacol caplet in a capsule. The capsules protect the patent, not the medicine.
You aren't the only one, nor the first one, to look inside the Delzicol capsule. Others on this board have done this and reported it in other threads. Have a look around the board. There is a lot of good information here.
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01-02-2014, 10:37 AM   #134
jrogers
 
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You aren't the only one, nor the first one, to look inside the Delzicol capsule. Others on this board have done this and reported it in other threads. Have a look around the board. There is a lot of good information here.
Indeed they have. I apologize for not having tracked that thread ("Asacol HD question") down before sounding off.

Thanks,
JRogers
02-24-2014, 05:04 PM   #135
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Hello!! I was wondering if anyone is taking another med that is similar to Asacol, but much cheaper? I understand that generic Asacol was discontinued and Delzicol is the new drug, but I currently do not have insurance and it is quite expensive. Is there any help out there to get your meds? Asacol 800 mg is priced at Target for 180 tablets at $900 and Delzicol is between $250-300! Just thought I may ask. Thank you!!!
02-24-2014, 06:16 PM   #136
kh216
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I take Lialda. I don't know how much it costs because I am on a prescription drug plan. However, I think it works just as well as Asacol HD.
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03-01-2014, 02:40 PM   #137
jrogers
 
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I'm paying 410$US for 180 400mg Delzicol. I don't recall exactly how much I was spending on Asacol, but the version that continues to be marketed in the US is the HD version, which appears to have been released primarily for patent protection. So it would not be at all surprising for it to be very expensive.

Lialda looks like a interesting alternative. It, like Asacol, is delayed release, which seems to reduce systemic exposure to the mesalamine (which makes me sick as a dog). Does anyone have a sense of how much this costs (pre-insurance)?

(Don't think I'm permitted to post URLs. This is an ordinary http URL)
dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3098a080-be86-4265-9818-7fc4beab77b7

Thanks,
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Last edited by jrogers; 03-02-2014 at 01:01 PM. Reason: correct spell checker
03-02-2014, 06:55 AM   #138
dave13
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My GI wanted me to take pentasa.Extremely expensive on my plan.Asacol was listed in the formulary as a less expensive alternative.Did he mean Asacol HD if Asacol is discontinued? I'll ask him to clarify.I'll ask about Lialda as well.
03-02-2014, 03:53 PM   #139
2thFairy
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I'm paying 410$US for 180 400mg Delzicol. I don't recall exactly how much I was spending on Asacol, but the version that continues to be marketed in the US is the HD version, which appears to have been released primarily for patent protection. So it would not be at all surprising for it to be very expensive.

Lialda looks like a interesting alternative. It, like Asacol, is delayed release, which seems to reduce systemic exposure to the mesalamine (which makes me sick as a dog). Does anyone have a sense of how much this costs (pre-insurance)?

(Don't think I'm permitted to post URLs. This is an ordinary http URL)
dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3098a080-be86-4265-9818-7fc4beab77b7

Thanks,
JRogers
Lialda was about $800 a month before insurance when I was taking it 4 years ago.
06-12-2014, 02:26 PM   #140
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Is there any significant difference between the asacol HD 800 and the old asacol 400?
07-13-2014, 07:58 PM   #141
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I am currently an asacol dependent Crohnie who has been out of meds for over a week. My insurance company is being completely retarded about giving me the replacement drug, delzicol. Even with a peer to peer, which is the last step in the appeals process, they told my doctor that I have to try Lialda, Pentasa, and Apriso first and fail it before they will give the delzicol. I am in a state of utter shock. Why would they risk a hospital stay? The drugs both cost the same. I've been on asacol with success for 3 years. Now I am flaring and starting Lialda tomorrow, even though it releases in the small intestine and my disease is now concentrated in the large intestine only. What should I expect from Lialda? Anyone on it please let me know what to look out for in terms of side affects!
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07-13-2014, 08:52 PM   #142
2thFairy
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Now I am flaring and starting Lialda tomorrow, even though it releases in the small intestine and my disease is now concentrated in the large intestine only. What should I expect from Lialda? Anyone on it please let me know what to look out for in terms of side affects!
Lialda releases in the colon. The side effects should be no different from Asacol, since they are both mesalamine.

Good luck to you! I hope this change doesn't screw up everything for you.
08-06-2014, 05:39 AM   #143
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Just an update...been on Lialda for about 3 weeks now and feel like crap. I'm only awake at this crazy hour because I have such terrible joint pain that I cant sleep. I want my Asacol back!!!
06-15-2015, 06:44 AM   #144
IBD is a pain in the a$$
 
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It's all nice that everyone is sharing info & their personal experiences but what can be done to get the pharmis to stop this roller coaster ride we must endure, and potential health sacrifices, so that they can continue to reap high profits? How can this practice be changed? Class action? FDA complaints? Where can the consumer turn to for protection?
06-15-2015, 08:06 AM   #145
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At this point, I have tried Lialda, Pentasa, and Apriso. All with terrible side affects. My GI anyway said those all release in the small intestine and since my disease is primarily in the colon, they aren't really medically the right answer for me. Asacol was working just fine until they decided to rename it and put a capsule on it. So, I have been controlling my IBD with just Humira, which thank G-d is still paid for by my insurance. I have no idea what other recourse there is, since I've been thru 3 different meds that failed and have made appeals to the insurance company each time with the help of my GI. That is simply where it ends...if you want a certain med they won't cover, then you need to miraculously come up with the money to pay for it. So, most of us who do not come from odles of money end up doing without. At this point I'm doing relatively ok, considering I'm now 9 weeks pregnant and need to be off of my prilosec too. It wouldn't be the right time for me to fight to get back onto the Asacol/Delzicol anyway since I'm trying to get away with being on the least amount of medication necessary during the pregnancy, but if that wasn't the case and I really found that I needed the Asacol/Delzicol, I'd probably be pitching a fit daily.
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