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05-25-2013, 06:44 AM   #1
my little penguin
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Humira antibodies

http://rawarrior.com/antibodies-less...imumab-humira/


Doctors in the Netherlands found 28% of patients developed antibodies to Humira (adalimumab), most of them (67%) within the first few months of treatment. They measured serum adalimumab concentrations and “antiadalimumab” antibodies and found that patients who developed the antibodies had lower serum concentration of adalimumab (that means less Humira) in their bodies. They concluded that “the development of antidrug antibodies was associated with lower adalimumab concentration and lower likelihood of minimal disease activity or clinical remission.”
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05-25-2013, 06:50 AM   #2
my little penguin
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http://www.alpco.com/products/Anti-T...ira_ELISA.aspx

RESULTS: After 3 years, 76 of 272 patients (28%) developed antiadalimumab antibodies--51 of these (67%) during the first 28 weeks of treatment. Patients without antiadalimumab antibodies had much higher adalimumab concentrations (median, 12 mg/L; IQR, 9-16 mg/L) compared with patients with antibody titers from 13 to 100 AU/mL (median, 5 mg/L; IQR, 3-9 mg/L; regression coefficient, -4.5; 95% CI, -6.0 to -2.9; P < .001) and also those greater than 100 AU/mL (median, 0 mg/L; IQR, 0-3 mg/L; regression coefficient, -7.1; 95% CI, -8.4 to -5.8; P < .001). Patients with antiadalimumab antibodies more often discontinued participation due to treatment failure (n = 29 [38%]; hazard ratio [HR], 3.0; 95% CI, 1.6-5.5; P < .001) compared with antiadalimumab antibody-negative ones (n = 28 [14%]). Ninety-five of 196 patients (48%) without antiadalimumab antibodies had minimal disease activity vs 10 of 76 patients (13%) with antiadalimumab antibodies; patients with antiadalimumab antibodies less often had sustained minimal disease activity score in 28 joints (DAS28) (< 3.2; HR, 3.6; 95% CI, 1.8-7.2; P < .001) compared with antiadalimumab antibody-negative ones. Three of 76 patients (4%) with antiadalimumab antibodies achieved sustained remission compared with 67 of 196 (34%) antiadalimumab antibody-negative ones; patients with antiadalimumab antibodies less often achieved remission (DAS28 < 2.6; HR, 7.1; 95% CI, 2.1-23.4; P < .001) compared with antiadalimumab antibody-negative ones.
From:
http://www.ncbi.nlm.nih.gov/m/pubmed/21486979/
05-25-2013, 06:59 AM   #3
my little penguin
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http://m.gut.bmj.com/content/61/2/321.short

Trough levels
05-25-2013, 07:08 AM   #4
Farmwife
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I knew you were going to look that up!

Thanks
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I'm mom to............... Little Farm Girl 8 yr old
Ibd (microscopic)
(12/28/12),
dx Juvenile Arthritis
(12/13/13)
dx Erthema Nodosum
(8/13/14)
Bladder and Bowel Dysfunction
(10/14/13)
Ehlers-Danlos Syndrome dx (1/26/17)
Remicade started on (9/8/14)Every 4 wks
Azathroprine started on 10/9/15
EN/EEN- since (1/12/13)
Past Meds- LDN, Humira, Pred, MTX, Sulfasalazine
06-15-2013, 11:49 AM   #5
botrel4
 
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I just had the blood test to check for antibodies. I take Humira injections weekly. My blood test showed no serum (Humira) in my bloodstream and I have developed antibodies. Now I am just waiting for direction from my doctor as to what the next course of action is. Sigh...
06-15-2013, 08:11 PM   #6
DustyKat
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I'm sorry to hear that botre14.

I hope you get some answers soon and whatever is next works well!

Dusty. xxx
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06-16-2013, 06:20 PM   #7
Dexky
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Sigh!! Obviously, since we've gone from bi-monthly to weekly to testing positive for anti-bodies, we're heading down that track as well.
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EJ dx w/ Crohn's 12/09
PSC 3/10

No more 6mp
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06-16-2013, 10:36 PM   #8
Brian'sMom
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Bummer. 28 percent isn't that high...right!!
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Kathy, Mom of 14 yr old Brian
symptoms 2005, official dx 6/2010

Praying for Remission
Vedolizumab 8-8-14
Ileostomy 3/22/14
Multivitamin,Iron,Vit D

Total EEN 12-10-13 to:TPN 1-29-14 - 4-2-14
Tried:Azathioprine,Pred,Pentasa,Cimzia Bi weekly & MTX 9/2013 to 8/2014, Humira 1/2011-9/2013, w/oral mtx 5 mos in 2013. Remicade: Had allergic reaction Jan 2011 Built up antibodies by 3rd infusion.
Has done round of Flagyl due to abcess 12/10 and 10-21-13 which helped both heal quickly.
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