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06-12-2013, 08:59 AM   #1
wildbill_52280
Senior Member
 
Join Date: Sep 2009
FECAL TRANSPLANTS and how they could cure IBD.

While this guide discusses home-based fecal transplants, the opinion of Crohnsforum.com is that they should be done under the supervision of a trained clinician as fecal transplants are potentially dangerous. ALWAYS discuss any potential treatment with your doctor. - Forum Admin



Fecal Microbiota Transplants(FMT) have induced sustained drug free remissions in both forms of Inflammatory Bowel Disease(IBD) and may have cured some cases of IBD in small trials, according to Gastroenterologist Doctor Thomas J. Borody MD, Ph.d. Details of these reports are listed in section 1.

There are 14 F.D.A clinical trials planned for the use of fecal transplant in both forms of IBD. In this post you will find out everything about them. Fecal transplants restore missing bacteria in IBD patients by obtaining them from healthy donors stool, mixing a stool sample with saline solution in a blender and giving it to the patient as an enema. This procedure has been performed successfully at home, but if your decide to do it, be sure to read the papers in the post below for expert instruction, don't just jump into it, donors need to be absolutely healthy. http://www.cghjournal.org/article/S1...069-8/fulltext

Latest studies in IBD show reduced diversity of healthy bacteria that regulate the inflammatory response when compared to groups of healthy people without IBD. Therefore, it is believed by some scientists that the restoration of the bacteria in IBD patients will correct the abnormal inflammatory response. So far we have some good scientific evidence this may be the case, but it will take time to prove this theory with absolute certainty. With official reports of UC and Crohn's patients maintaining a drug free remissions for as long as 25 and 13 years, this provides some compelling supportive evidence that they may have been cured by FMT.

Other ways of performing a fecal transplant are orally through a nasogastric/duodenal/jujenal tube or pill form which is currently in development.So far the studies have shown when donors are well screened with blood tests and meet health criteria, this is generally a safe treatment.


My Experiances with Fecal Transplants: In this thread i have posts which detail my experiances with FMT, I was trying to find a way to make a FMT pill which proved pretty difficult, I ended up mixing a solution of chilled saline and stool and drinking it. This led to some improvements, such as gaining 10 pounds in 10 weeks, improved bowel movements, lowered anxiety, but the majority of my other symptoms remain so i will have to find a new donor and try it again, but I'm convinced doing this again will likely reduce the severity of my disease even more.

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Outline
1. History of Fecal Transplant in IBD: Its success so far
2. Clinical Studies Currently in progress
3. Testimonies.
4. General Information
5. How to select a Donor
6. How to perform a Fecal Transplant



------------------------------------

1. History of Fecal Transplants in IBD: Its Success So Far.


Dr. Borody Background
These studies were done by a doctor in Australia, Thomas J. Borody who is trained in Gastroenterology in addition to other education and experience in scientific research.

Educational/Career background on Doctor Borody.
BSc (MED) (HONS)(Bachelor of Science), MBBS (HONS)(Bachelor of medicine, Bachelor of Surgery), MD(Doctor of Medicine), PhD(Doctor of Philosophy), FRACP(Fellow of the Royal Australasian College of Physicians), FACG (Fellow of the American College of Gastroenterology), FACP (A Fellow in the American College of Physicians), AGAF (American Gastroenterology Association Fellow)

Link to his website where this information was derived-
http://www.cdd.com.au/pages/clinical_staff.html

Here is a link to the U.S. National Library of Medicine /National Institute of Health where a search on his name will show some of his published contributions to various Medical/Scientific journals, search results on this database reveal 74 references to his name which illustrate more documentation of his professional experience. These references date from as recent as 2013 to as far back 1979, spanning about 34 years.
http://www.ncbi.nlm.nih.gov/pubmed/?term=borody+t



Fecal Transplant Studies on IBD -

1989 – Doctor Borody first used fecal transplants in 55 patients with a wide range of Gastrointestinal disorders ranging from constipation, diarrhea of unknown cause, Crohn’s disease and ulcerative colitis. 20 were considered cured. 9 were improved and 26 were unchanged. At least one of the cured patients were cured of Crohn’s disease and one of ulcerative colitis. This is an early study so it was unknown how many times a transplant may have to be done to get any results.

http://www.cdd.com.au/pdf/publicatio...010%20p604.pdf


2003- Doctor T.J Borody tried this therapy on 6 patients with ulcerative colitis, that elimated all signs of disease symptoms without drugs ranging from 1-13 years after therapy. These patients are considered to be potentially cured since there is no sign of disease, no longer need medication beyond 2 years and they remain disease free to this day. This study was published in the journal of clinical gastroenterology.
http://prdupl02.ynet.co.il/ForumFiles_2/28701499.pdf

2011- The same researcher Dr borody reported results in a group of patients with Crohn’s disease and all patients obtained remission without drugs. These were severe cases that didn’t respond to any medication before doing the fecal transplant. The results and details of this study were presented at the American College of Gastroenterology’s (ACG) 76th Annual Scientific meeting in Washington, DC in November of 2011. Here is the Official news release from the American college of gastroenterology-
http://d2j7fjepcxuj0a.cloudfront.net...FINAL_1025.pdf

references for the 2011 fecal transplant study on crohn’s
Some reports of the ACG meeting in 2011 on various news websites
http://www.medicalnewstoday.com/releases/236885.php
http://www.sciencedaily.com/releases...1031114945.htm

2013
July- 14 year old boy with crohns achieves remission with FMT -http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742951/?report=classic

September- Early results from the mcmaster study, news segment-
http://www.ctvnews.ca/health/experim...ases-1.1445800

November - man with severe crohn's disease achieves complete remission without drugs and with only one fecal transplant delivered orally.
http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract

November- patient with crohn's responds to fecal transplant
http://www.ncbi.nlm.nih.gov/pubmed/24239403
FULL TEXT
http://ecco-jcc.oxfordjournals.org/content/8/3/256



2014

March- Woman remains in remission for 13 years after recieving an oral fecal transplant for Crohns disease, she may have been cured. http://www.abc.net.au/news/2014-03-1...seases/5329836

additional source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868025/
http://www.ncbi.nlm.nih.gov/pmc/arti...025/figure/F2/

May-Mcmaster Ulcerative Colitis Study.
Mixed results, some bad responses while some very good responses to FMT.
http://www.medscape.com/viewarticle/824930

August - Beth Israel deaconess Medical center Crohn's Disease,
After 4 weeks of follow-up, 55% had clinical response; 36% were in clinical remission.
http://www.healio.com/gastroenterolo...crohns-disease

2015

January-Crohn's- 23 out of 30 patients achieve remission with one oral administration of Fecal Transplant.
http://www.ncbi.nlm.nih.gov/pubmed/25168749

March-Crohn's-
http://journals.lww.com/ibdjournal/F...linical.7.aspx



Fecal Transplant History of use for C. Difficle Infection.

Here are some reports about the latest study on Fecal Transplants outperforming standard Antibiotic therapy for C. Diff.-
http://www.cbsnews.com/8301-204_162-...y-c-difficile/

Here is a link to the actual study published in the New England journal of medicine 2013
http://www.nejm.org/doi/full/10.1056...037#t=abstract

EXCERPT from the study-
“The study was stopped after an interim analysis. Of 16 patients in the infusion group, 13 (81%) had resolution of C. difficile–associated diarrhea after the first infusion. The 3 remaining patients received a second infusion with feces from a different donor, with resolution in 2 patients. Resolution of C. difficile infection occurred in 4 of 13 patients (31%) receiving vancomycin alone and in 3 of 13 patients (23%) receiving vancomycin with bowel lavage (P<0.001 for both comparisons with the infusion group). No significant differences in adverse events among the three study groups were observed except for mild diarrhea and abdominal cramping in the infusion group(fecal transplant) on the infusion day.







Here is a quote by University of Minnesota Doctor and Researcher Alex Khoruts
some info on him- http://www.med.umn.edu/gi/faculty/khoruts/

"Those of us who've been doing this procedure(fecal transplant) for some time didn't need any more convincing, but the large medical community needs to go through these steps," Dr. Alexander Khoruts, a gastroenterologist at the University of Minnesota in Minneapolis who was not involved in the new study, told Nature. "It's an unusual situation where we have more than 50 years of worldwide experience and more than 500 published cases, and only this far along does a randomized trial appear.”

link to quote- http://www.cbsnews.com/8301-204_162-...y-c-difficile/




2. CLINICAL STUDIES: Currently In Progress


These studies were found on www.clinicaltrials.gov. To verify their existence, enter the identifier code into the website search engine.

-----------------------------------------
Pediatric Inflammatory Bowel Disease(Ulcerative colitis)
Helen DeVos Childrens Hospital (HDVCH)
Grand Rapids, Michigan, United States, 49503
ClinicalTrials.gov Identifier: NCT01560819
Estimated Primary Completion Date: May 2013

recently released study results April 4, 2013-
http://www.sciencedaily.com/releases...0405112859.htm

excerpt-
“Results showed that, 78 percent subjects achieved clinical response within one week while 67 percent subjects maintained clinical response at one month after FMT. Thirty-three percent subjects did not show any symptoms of ulcerative colitis after FMT. Patient's clinical disease activity (PUCAI score) significantly improved after FMT compared to the baseline. No serious adverse events were noted. “Patients often face a tough choice between various medications that have significant side effects. Allowing the disease to progress can lead to surgical removal of their colon," said Dr. Kunde. "Our study showed that fecal enemas were feasible and well-tolerated by children with ulcerative colitis. Adverse events were mild to moderate, acceptable, self-limited, and manageable by patients."


----------------------------------------------------------
Ulcerative Colitis
University of Washington
Seattle, Washington, United States, 98103
ClinicalTrials.gov Identifier: NCT01742754
Estimated Study completion Date: April 2013
------------------------------------------------------------------------
Ulcerative colitis
Academic Medical Center
Amsterdam, Netherlands, 1100DD
ClinicalTrials.gov Identifier: NCT01650038
Estimated study Completion Date: December 2013
------------------------------------------------------------------------
Ulcerative Colitis
Hamilton Health Sciences / McMaster University
Hamilton, Ontario, Canada, L8N 3Z5
ClinicalTrials.gov Identifier: NCT01545908
Estimated Primary Completion Date: March 2014

-----------------------------------------------------------------------
Crohn's Disease
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
ClinicalTrials.gov Identifier: NCT01847170
Estimated Enrollment: 20
Study Start Date: May 2013
Estimated Study Completion Date: April 2014
-------------------------------------------------------------------------
Crohn’s disease and Ulcerative colitis
Seattle Children's Hospital
Seattle, Washington, United States, 98105
ClinicalTrials.gov Identifier: NCT01757964
Estimated Primary Completion Date: December 2014
--------------------------------------------------------------------------
Crohn’s Disease
Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210011
ClinicalTrials.gov Identifier: NCT01793831
Estimated Study Completion date: December 2014
--------------------------------------------------------------------------
Ulcerative Colitis
Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210011
ClinicalTrials.gov Identifier: NCT01790061
Estimated Study Completion Date: December 2014
--------------------------------------------------------------------------
Ulcerative Colitis
University of Chicago Medicine Recruiting
Chicago, Illinois, United States, 60637
ClinicalTrials.gov Identifier: NCT02058524
Estimated Enrollment: 20
Study Start Date: June 2013
Estimated Primary Completion Date: June 2015
------------------------------------------------------------------
Ulcerative Colitis
University of South Wales
ClinicalTrials.gov Identifier: NCT01896635
Estimated Enrollment: 80
Study Start Date: September 2013
Estimated Study Completion Date: September 2016

-------------------------------------------------------------------------
Ulcerative Colitis
Texas Children's Hospital/Baylor college of medicine
ClinicalTrials.gov Identifier: NCT01947101
Estimated Enrollment: 10
Study Start Date: December 2013
Estimated Study Completion Date: December 2016

---------------------------------------------------------------------------

Crohn's Disease
Gastroenterology department, Saint Antoine Hospital
Paris, France, 75571
ClinicalTrials.gov Identifier: NCT02097797
Estimated Enrollment: 18
Study Start Date: March 2014
Estimated Study Completion Date: February 2016
------------------------------------------------------
IBD both forms
Department of General Surgery, Jinling hosptal,Medical School of Nanjing University Nanjing, Jiangsu, China, 210002
ClinicalTrials.gov Identifier: NCT02016469
Estimated Enrollment: 30
Study Start Date: December 2013
Estimated Study Completion Date: February 2016

--------------------------------------------

--------------------------------
IBD both forms
Wolfson Medical Center, Holon, Israel.
ClinicalTrials.gov Identifier: NCT02033408
Estimated Enrollment: 20
Study Start Date: January 2014
Estimated Study Completion Date: January 2016

------------------------------------------------
Seattle Children's Hospital, David Suskind.
ClinicalTrials.gov Identifier:NCT02272868
Estimated Enrollment: 32
Study Start Date: October 2014
Estimated Study Completion Date: October 2016
3. TESTIMONIES.
-


Testimony #1

This is the best testimony I have found so far because it is so detailed. This is a guy who used his son and his wife as donors. You don’t have to watch the entire videos, you can skip to the parts I have defined in the summary to verify the story. You will notice in the last video that the energy in his voice changes and his speaking ability improves a bit and his mood seems slightly improved, which are signs his health has is improving due to the fecal transplants.


Video #1 – http://www.youtube.com/watch?v=3w7rjqdpDa0
video length- 33 minutes

Summary of video/skip to these parts-
2:52- 30 years old, Married for 8 years, Bachelors degree in Business Adminstration, Self Employed, Works in financial services industry, Healthy most of life. Has had ulcerative colitis for about 5 years.
7:20- Took antibiotics for 2 years for staph infections on legs, he suspects the antibiotics had something to do with his development of IBD as symptoms appeared while on antibiotics.
9:50 - Description of initial onset of disease.
14:30-19:00 Describes symptoms before doing the fecal transplant which include Fistula, fissures, hemmorhoids. Starting transplants on meds @ 40 mg prednisone recently at 80mg. explains all the medications he has tried during the course of his disease for IBD.
26:00 when and how he heard about fecal transplants


Video day#3-http://www.youtube.com/watch?v=RvGnYkgAWgM
Summary
1:25 bowel movement frequency reduced from 20X per day to around 2x per day, in about 5 days


Video Day #20 http://www.youtube.com/watch?v=aMkSLt1xbRU
2:50 almost entirely off of medication at this point. he’s generally still doing very well bowel wise and feeling pretty good.
6:00 encourages people to try it, considers it a miracle for him and his condition.


Latest update April 30th, 2013- http://www.youtube.com/watch?v=kamIEzFpdJ8

0:00-3:30 gained 30 pounds since starting fecal transplants, eats a normal diet now and most symptoms are gone without medication.
3:30-7:32- tips on how to perform the transplant




Testimony #2-

His screen name is Dr. Briggs and he is a university physics professor who is trained as a scientist and who has done the treatment successfully at home using his wife as a donor.
link to the forum discussion where this testimony was found- http://www.healingwell.com/community...&m=2541306&p=4

summary- he has had ulcerative colitis for 12 years, then later was diagnosed with crohn’s disease. He suspects that a course of antibiotics had something to with him developing IBD.
symptoms before starting the Fecal transplant were 3 bm’s per day, previously he has had up to 20 per day. after the transplants he averaged 2 bms a day and he was able to eat foods that used to cause his symptoms to worsen, this indicates a major change occurred in his ability to digest food.

A few quotes from his fecal transplant experience-
posted on 11/27/2012
Dr Briggs-
“So, things are going very well. To recap - I was diagnosed with UC about 12 years ago, and spent time on sulfasalazine and prednisone with no benefit (15-20 bloody very loose stools a day), then eventually Remicade after developing a fistula. I was on the Remicade for a little over 7 years, which partially controlled things (5-7 loose stools a day, no bleeding as long as I got infusions every ~11 weeks).
I am now off all medications, and doing great. Two well-formed stools a day.”

Posted 2/28/2013 1:14 PM

Dr briggs- “Sorry for not responding sooner (a lot sooner) - with my UC seeming to be completely gone, I'm getting caught up in other things, so I have to remind myself to occasionally check out this thread.
Potatoes are often not well digested if you have a compromised GI system, they have lots of complex starches in them. I can eat them now without problems, but before the transplants they gave me issues - and early on after the transplants when I ate potatoes they would give me a very mushy stool afterwards (I have continued healing since the transplants, and now tolerate everything very well it seems - except wheat). “




Testimony# 3

Here is another testimony from a women with the screenname bustersmom, she avoided a colectomy by doing a fecal transplant at home using her husband as a donor-
link-http://www.crohnsforum.com/showthread.php?t=15548&highlight=bacteriotherapy

post# 139
I have Crohn's disease and was on Flagyl and Cipro for over two weeks and got three abscesses. I figured i had nothing to lose by trying the transplant. I waited three weeks after finishing the antibiotics and was in bad shape. abscesses were terrible. I did the transplant daily for a while and the abscesses, Two which were large, Began to shrink every day. After a month they were gone, and made NO fistula! I haven't had one bit of trouble down there since. I believe the transplants work. I don't know if it works all through the colon, but it worked on me in my lower colon and i was a complete mess. Bree


Testimony#4

"Last Fall I went to Sydney Australia on a vacation and while I was there I looked into their programs and research. I found FMT. Fecal Microbiota Transplantation. I was grossed out and said oh hell no. Still, the more I studied and read the more it seemed worth a try. So, I called my doctor here and asked if I could be in one of the clinical studies. Unfortunately there wasn't one here. Only in Portland Oregon. He happened to know the doctor running the study though and offered me another way to treat myself at home. My husbands stool was tested for HIV, Hep A B and C, C Diff, and he passed all the tests with flying colors. So, we bought a retention nozzle, enema bag, tons of Zip lock freezer bags, went through training with our nurses so he could help me complete the series of enemas and my flora was checked and measured by my doctor every other week 7 days after each treatment. I was really sore down there from all the surgeries so instead of 7 days of back to back enemas we changed it to once every other week for 2 months.
I felt it was my last hope and I wanted to try something because nothing else seemed to work and I just wanted to become a guinea pig if I could. 4 months after my (home treatment) I went in for a scope, except some scarring from the past issues I had no inflammation, no diarrhea, no pain, and had started to work out again. I have felt better this past year than I have since I was 26. I have my life back! I have not been on any meds for 6 mos and after my scope today I was told I was in complete remission. (They still don't know how long it may last or if it will.) Right now I feel normal, no pain, no D and I have energy again!"

source-
http://www.crohnsforum.com/showthread.php?t=48939

4. GENERAL INFO
Here are some general videos explaining how this treatment has potential for IBD and many other diseases. Various environmental toxins and even antibiotics are suspected to be involved in damaging intestinal bacteria, which may contribute to developing these conditions.



Video Interview of Professor Lawrence J. Brandt.
Here are some credentials/education: Chief Emeritus of Gastroenterology and Professor of Medicine and Surgery at the Albert Einstein College of Medicine. He also has been performing studies on fecal transplants in C difficile in the U.S. since about 1999. C difficile is very similar to Inflammatory Bowel disease which the mains symptoms are chronic diarrhea and often include colonic inflammation just like inflammatory bowel disease.

Link to verify Professor Brandt’s credentials http://www.einstein.yu.edu/departmen...le.asp?id=2519



Part 1- http://www.youtube.com/watch?v=JRZxOU1x71c
-talks about his experience studying fecal transplants for C. Difficile Infection.

Part 2- http://www.youtube.com/watch?v=ot7e9bQO2U8
-his opinion on fecal transplant overall safety, and its potential for other diseases.

Part 3- http://www.youtube.com/watch?NR=1&fe...&v=u8eNvAVfc0M
SUMMARY-
1:10 history of fecal transplant in veterinary medicine
2:18 different routes of administration of Fecal transplant
3:00 self/home administration of fecal transplant
4:00 more on the future and potential of Fecal Transplant
5:38 mentions pill form as the final future method of administration in the future for fecal transplant.


here is an article published on February 13, 2013 by Lawrence J. Brandt and another professional which was published in current opinion in gastroenterolology

Fecal Microbiota Transplantation: Past, Present and Future
Olga C. Aroniadis, Lawrence J. Brandt
Curr Opin Gastroenterol. 2013;29(1):79-84.
link to article-
http://www.medscape.com/viewarticle/776501_1


Video, By Cara Louise Santa Maria - Science educator, Masters
Degree in Neuroscience
link- http://www.youtube.com/watch?feature...&v=kLB5Pasjjis



Here is a very well written article On FMT by KSS , a member of this website. there are testimonies of people who have tried Fecal transplant in this article.
http://diyehr.com/analysis-of-crohno...eatment-study/


Article for TIME magazine in June 2012 about microbiome research-
http://healthland.time.com/2012/06/1...p-you-healthy/


http://commonfund.nih.gov/hmp/overview


Dr. Martin Blaser has studied the role of bacteria in human disease for over 30 years. He is the director of the Human Microbiome Program at NYU. His new book was just published and discusses the new evidence suggesting antibiotics have contributing to rising rates of diseases like Crohn's by killing off good microbes. - http://martinblaser.com/

http://www.npr.org/2014/04/14/302899...ome-any-favors

http://www.amazon.com/gp/product/080...&tag=yoadsu-20

--------------------------------------------

5. How to Select a Donor

Overall, as long as the Donor is in good health, there is very little risk with doing a fecal transplant. Even in some of the documents below they reported bypassing blood tests and health screening for some patients who chose a donor that was a family member that they knew and trusted, buts it probably best to take precautions. All the criteria for selecting a healthy donor and directions for what blood tests they need were obtained from these two papers, one of which was written by doctor Borody and other professionals in the field.



Requirements:
NO ANTIBIOTICS IN LAST 6 MONTHS, OR EVER IS BEST.

NO Gastrointestinal COMPLAINTS LIKE FREQUENT DIARHEA OR CONSTIPATION/excessively firm stool that is hard to pass, blood, No Mucus in stool or intestinal pain. You should have a generally regular stool frequency of 1-2 bowel movements per day.


Absence of metabolic syndrome- http://en.wikipedia.org/wiki/Metabolic_syndrome
Symptoms and features are:
-Fasting hyperglycemia — diabetes mellitus type 2 or impaired fasting glucose, impaired glucose tolerance, or insulin resistance
-High blood pressure
-Central obesity (also known as visceral, male-pattern or apple-shaped adiposity), overweight with fat deposits mainly around the waist
-Decreased HDL cholesterol
-Elevated triglycerides
Associated diseases and signs are: hyperuricemia, fatty liver (especially in concurrent obesity) progressing to NAFLD, polycystic ovarian syndrome (in women), and acanthosis nigricans.

No autoimmune conditions- list of conditions-
link- http://womenshealth.gov/publications...diseases.cfm#d

No allergic diseases - asthma, atopic dermatitis (eczema), allergic rhinitis (hay fever), food allergies



Required Blood Tests for donors- full blood count, liver function,
Negative viral screening for HIV 1 and 2, Hepatitis a, b, c. cytomegalovirus, Epstein Barr Virus, Syphilis.



Some studies have bypassed donor screening only in cases where close family members have been selected as donors.

None of the Testimonys I listed in sections #4 of this paper mentioned taking the suggested precautions to follow the donor selection criteria, as most were able to get help from family members who they were confident were healthy. I plan on taking full precautions no matter how healthy my donor is, or whether they are a family member or not. I also have additional criteria that go beyond the advice listed here.

The papers below is where i found most of this information. It is not required that you read these papers with the web links listed below, but if you would like to look them up to verify they exist, feel free to do that.

Article 1
Details on page 3-
http://www.2ndchance.info/inflambowel-Hamilton2011.pdf

Article 2
Details on page 479-
http://www.cdd.com.au/pdf/publications/paper12.pdf




Recommended diet for donors- this will encourage all the good bacteria in your intestine to grow and make it a more potent medicine.
High fiber foods, like whole grain oats and wheat
Berries.
eat at least one apple per day.
veggies.
if you smoke, reduce your smoking as much as possible.

Things to avoid- anything with aspartame or saccharin in it, excessive meat. excessive amounts of processed food in packaging as it may contain preservatives that inhibit bacterial growth.
over consumption of meat- beyond 8 ounces in a day would be excessive.

other tips-
if you become sick or get food poisoning while doing the transplants you will have to stop until you become better.

--------------------------
6. How To perform a Fecal Transplant

chapter a work in progress


RECTAL METHOD/BY ENEMA
I have not included yet any details on how the transplant is done in any precise way, but typically it is done by making a solution of saline (.9% sodium chloride solution/aka salt water) mixed with stool in a blender and giving it as an enema to retain in the body for 6-8 hours or as long as your body can hold it. I will add more very soon but i think it's all here if you want to figure out the details for yourself, otherwise i will soon give some better instructions to make it easy for people to try themselves. There are some details on page 5 and 6 of this paper by doctor borody.
http://www.cdd.com.au/pdf/publications/paper12.pdf

how to make saline solution at home-Quick instructions- mix one gallon of distilled water with 4 teaspoons of salt(preferablly pharma grade neti pot salt) in a pot and stir on low heat so salt easily dissolves. this will make a gallon of saline solution.

.9% sodium chloride w/v solution is expressed as a mass concentration weight/volume solution. in other words, it is telling us how much mass of a certain substance is dissolved within a volume of a fluid. in this case, 100 milliliters of a fluid. and in this case sodium chloride aka salt. So there is .9 grams(just shy of one full gram) of salt dissolved in every 100 milliliters of h20 aka water.

more to come...

Last edited by wildbill_52280; 08-21-2015 at 11:34 PM.
06-15-2013, 08:45 AM   #2
***Lisa***
Forum Monitor
 
***Lisa***'s Avatar
 
Join Date: Feb 2013
Thank you for posting this, Wildbill! I have been trying to find this info in one location and here it is! My daughter goes to a GI from a large hospital and when we asked about it, they said they are not doing them now, but will be "soon." How can the donor have their stool tested if GIs refuse to run test it for us? Please keep posting anything you find! The FMT is very promising and needs to be made available to the general public ASAP. Thanks again!
06-15-2013, 11:50 AM   #3
wildbill_52280
Senior Member
 
Join Date: Sep 2009
I wont claim to be an absolute expert on this but here is some information.

you can order these tests yourself through online companies like labtests online, here is a link-
http://labtestsonline.org/understand...lture/tab/test
http://labtestsonline.org/understand...es/op/tab/test

but i would say testing the stool may not be necessary for a fecal transplant donor, unless they are a complete stranger, who may give a biased/inaccurate report on their health status. Otherwise if they are a friend or family member you can trust to tell you about gi system abnormality, testing the stool is not necessary. But testing for hiv and hepatitis should always be done for a donor.

It will be easy to tell if the person's gi tract has been infected by some pathogen, as they will have symptoms like diarhea etc. that lasts for a few days. There is only one other exception and that is certain parasites that may persist without symptoms. i would say that risk is very minimal and non serious and in almost every case, diarhea would be a symptom of this infection which your donor would inform you of if they are honest and trustworthy.

Last edited by wildbill_52280; 06-15-2013 at 12:33 PM.
06-24-2013, 11:44 PM   #4
wildbill_52280
Senior Member
 
Join Date: Sep 2009
News Update

FDA Grants Fast Track Designation to Rebiotix for Its Microbiota Product for Recurrent Clostridium difficile Infection. Wall Street Journal, June 24, 2013
http://online.wsj.com/article/PR-CO-...googlenews_wsj




What is REBIOTIX?

all the descriptions are vague, but its basically a "preparation" of live bacteria to solve current problems of giving someone a fecal transplant. I believe they are talking about a creating pill to take orally, but they don't say this anywhere, nor describe the product in development.



What is the fda fast track development program?

The FDA Fast Track Development Program is a designation of the United States Food and Drug Administration (FDA) that accelerates the approval of investigational new drugs undergoing clinical trials with the goal review time of 60 days. Such status is often given to agents that show promise in treating serious, life-threatening medical conditions for which no other drug either exists or works as well.

http://en.wikipedia.org/wiki/FDA_Fas...opment_Program


having some sort of fecal transplant pill would be cool, although im not positive that is what they are developing. but what other kind of product would they be developing and selling right?

Last edited by wildbill_52280; 06-25-2013 at 12:06 AM.
06-27-2013, 12:02 AM   #5
wildbill_52280
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Best Pract Res Clin Gastroenterol.
2013 Feb;27(1):127-37. doi: 10.1016/j.bpg.2013.03.003.
Fecal transplant: A safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?


Source
Department of Internal Medicine, AMC, University of Amsterdam, The Netherlands.

Abstract
Recent studies have suggested an association between intestinal microbiota composition and human disease, however causality remains to be proven. With hindsight, the application of fecal transplantation (FMT) does indeed suggest a causal relation between interfering with gut microbiota composition and a resultant cure of several disease states. In this review, we aim to show the available evidence regarding the involvement of intestinal microbiota and human (autoimmune) disease. Moreover, we refer to (mostly case report) studies showing beneficial or adverse effects of fecal transplantation on clinical outcomes in some of these disease states. If these findings can be substantiated in larger randomized controlled double blind trials also implementing gut microbiota composition before and after intervention, fecal transplantation might provide us with novel insights into causally related intestinal microbiota, that might be serve as future diagnostic and treatment targets in human disease.
07-15-2013, 11:54 AM   #6
wildbill_52280
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a new video that is related

http://www.youtube.com/watch?v=Ke0_y...mmVAiSq9YtfGlA
07-18-2013, 11:57 AM   #7
wildbill_52280
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more updates:

The Problem of DIY Fecal Transplants
If the FDA continues to heavily regulate the procedure, people will do it themselves.
ANDI L. SHANE JUL 16 2013, 9:02 AM ET

http://www.theatlantic.com/health/ar...plants/277813/
07-22-2013, 11:21 AM   #8
wildbill_52280
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here is a great new testimony of someone trying a Fecal transplant.

http://www.healingwell.com/community...f=38&m=2799459

Last edited by wildbill_52280; 08-28-2013 at 01:10 PM.
07-23-2013, 09:28 AM   #9
723crossroads
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here is a great new testimony of someone trying a Fecal transplant and also provides an example of why i have developed a way to encapsulate fecal material to be taken orally:

http://www.healingwell.com/community...f=38&m=2799459
Thanks WildBill.
I was interested in knowing about this and it did help me understand what it is all about. I hope the capsules become mainstream and can be prescribed.
07-24-2013, 07:03 AM   #10
Beach
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here is a great new testimony of someone trying a Fecal transplant and also provides an example of why i have developed a way to encapsulate fecal material to be taken orally as enemas are difficult to perform correctly and reach entire affected colon up as far as the ileocecal valve, and especially for crohn's which involves the ileum and small intestine where an enema would never reach.

http://www.healingwell.com/community...f=38&m=2799459
I used to work in the encapsulation industry. When I saw this, in a way made me chuckle in that I can see companies hesitation in bringing fecal matter into their facilities. They would do it I'd imagine once QC was satisfied, just the sanitation issues that would need to be resolved.

You might not be interested in mentioning due to proprietary reasons, but what route are you looking at, softgel or two piece?
07-30-2013, 12:04 AM   #11
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Rebiotix Receives FDA IND Approval to Begin Phase 2 Trial of Pioneering Microbiota Restoration Therapy
Reuters.
Mon Jul 29, 2013 5:10pm EDT

Rebiotix Inc. announced today that the U.S. Food and Drug Administration has approved the company’s Investigational New Drug (IND) application to begin the Phase 2 clinical study of RBX2660 for the treatment of recurrent Clostridium difficile infection (CDI). If successful, RBX2660, a preparation containing live microbes designed to rebuild a healthy intestinal microbiome, has the potential to become the first FDA-approved drug based on the human microbiome.

About RBX2660
RBX2660 (microbiota suspension) is a preparation containing live microbes designed to rebuild a healthy intestinal microbiome.

Fecal transplant, the predecessor to microbiota restoration therapy, has demonstrated high rates of success in curing recurrent CDI in clinical studies. However, the non-standardized and unappealing processes involved in sample preparation, in addition to expensive and time-consuming donor screening, are limiting factors for patients and physicians. RBX2660 is designed to solve these problems and, if clinically successful, is anticipated to be physician friendly, ready to use, and available on demand.

About the Planned Clinical Study
The PUNCH™ CD study is designed to assess the safety of RBX2660 (microbiota suspension) for the treatment of recurrent Clostridium difficile-associated diarrhea (CDAD). Secondary objectives of the multi-center, open-label study include gathering efficacy information, data to assess patient quality of life, and cost-effectiveness of the therapy.

full article- http://www.reuters.com/article/2013/...00+BSW20130729


they still havent said whether or not this is a fecal transplant pill or what the live bacteria preperation actually is, but i still anticipate it is a fecal transplant pill.
07-30-2013, 01:37 AM   #12
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so this trial is going to be for Cdiff? Then hopefully for Crohns
07-30-2013, 11:31 AM   #13
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so this trial is going to be for Cdiff? Then hopefully for Crohns
the time will come, but so far the evidence we have for crohns and fecal transplants is only good, but not great. so some doubt remains whether it can ever be as effective for crohns as it has been shown to be for ulcerative colitis. i believe the protocol for treating crohns with a fecal transplant has to be improved somehow, such as following a special diet, only taking bacteria in an oral capsule daily or even multiple times a day and taken simultaneouly with fiber. not until extreme measures like this are added to the protocol will we begin to generate better results for crohns.

the soonest studies on fecal transplant for crohn's isnt until december 2014. we may have to wait another year from that until they build upon the results of that study, to show that there IS STILL potential for fecal transplant for crohn's.

for me it is a matter of interpretation of current evidence. people may interpret the lack of dramatic success of FMT for crohns as meaning, "see, FMT isnt working as good as is for UC, therefore, no further studies are needed" and i say to that, the protocol just needs to be different, that is why the results have been different, because of differences in nature of crohn's compared to UC. The evidence that exists doesnt prove that FMT will not work for crohns, therefore, potential still exists, and not until the fecal transplant pill is tried in crohns will we start to see any good results for crohns. there are currently no plans on doing it this way that i am aware of from searching clinical trials.gov or reading almost every study that exists, although they do mention oral route may be better for crohns, just no mention of the use of pills or the nature of a protocol that differs from the status quo.

Last edited by wildbill_52280; 08-28-2013 at 01:11 PM.
08-04-2013, 10:08 PM   #14
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relevant news article:

http://www.examiner.com/article/feca...r-life?cid=rss
08-06-2013, 08:12 AM   #15
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One thing that I´ve noticed several times...is that everytime someone else have used a toilet before me, their "aftermath" smells so much more than my shit...the smell is very strong and profound, but mine never smells too much. I wonder if that is a evidence of a diverse flora vs simplified flora?!? I don´t know if you guys have ever noticed.
08-06-2013, 01:44 PM   #16
***Lisa***
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One thing that I´ve noticed several times...is that everytime someone else have used a toilet before me, their "aftermath" smells so much more than my shit...the smell is very strong and profound, but mine never smells too much. I wonder if that is a evidence of a diverse flora vs simplified flora?!? I don´t know if you guys have ever noticed.
I've noticed the same thing with my daughter who has CD. The stinkier her BMs, the better she feels.
08-06-2013, 02:57 PM   #17
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Lisa: Very interesting indeed, as it does not matter if it´s an adult or a kid, like today at the indian restaurant, very distinct odor...almost "personal". Funny thing though, Before I was diagnosed I never had this odorless poop.

Hopefully my FMT next month will fix this.
08-06-2013, 06:19 PM   #18
wildbill_52280
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relevant video:

http://www.youtube.com/watch?v=JVSvbR_sU14
08-07-2013, 02:55 PM   #19
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Vets are def way ahead of doctors. They don't need 8 years to get through the clinical trials.
08-08-2013, 08:07 AM   #20
sir.clausin
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FMT: What works and what doesn´t

http://thepowerofpoop.com/interview-...splant-doctor/

Wildbill: I know you are a strong believer of FMT for Crohns too and Kiny is not for example, only time will tell, but it says that FMT for crohns is unsatisfying.

I wonder and might be so:

UC: Gut dysbiosis
Crohns: "Gut dysbiosis+leaky gut+?
08-08-2013, 12:09 PM   #21
wildbill_52280
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FMT: What works and what doesn´t

http://thepowerofpoop.com/interview-...splant-doctor/

Wildbill: I know you are a strong believer of FMT for Crohns too and Kiny is not for example, only time will tell, but it says that FMT for crohns is unsatisfying.

I wonder and might be so:

UC: Gut dysbiosis
Crohns: "Gut dysbiosis+leaky gut+?
great article and thanks for showing it to me.

here is his direct quote:

What kind of successes and non-successes have you seen with FMT?

We’ve had excellent results with C. diff. and UC. Our success rate for the treatment of C. diff. is nearly 100% and for ulcerative colitis it is in the range of 70 to 80%. We’ve also seen IBS-D predominant patients reduce their diarrhea significantly. The use of FMT to treat Chrohn’s patients has been disappointing.

- See more at: http://thepowerofpoop.com/interview-....Oib7agGW.dpuf
ok, so he is not giving very much information about his experiances or methods, and certainly not enough quality information for me to completely change my position. and my position is, he is right, crohn's will at first be more difficult to treat then UC, this is what i always anticipated. this is likely because of the protocol being used. Recurrent daily applications by oral infusion(gastric, doudenal, pill form) is when you will see better results for crohns disease, and also in addition to dietary changes.

We also still have other good sources of information for us to believe there still is potential for FMT with crohn's such as borody's experiments on crohn's patients which seemed successful. so even though its not absolutly clear yet whether crohns will be cured or can be treated with a fmt, there has not ben enough good studies yet. There are more reasons for us to believe that potential exists, then to falsely, or conclude too early, that it absolutly doesnt work at all.
08-09-2013, 11:23 PM   #22
wildbill_52280
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here is a testimony of a person who used a Fecal transplant to treat her IBS, and she says it seems like she is cured.

http://www.reddit.com/r/IAmA/comment..._is_now_cured/

FYI tho, the use of FMT for IBS has been documented in the scientific literature already, but im not sure if any more studies are in the works or not. if not now, then very soon there will be more studies for IBS.
08-09-2013, 11:51 PM   #23
wildbill_52280
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Here is another testimony/news article of a person who used Fecal transplant to treat crohns disease.

Some, like Toronto resident Charlie Curtis, are even using the treatment for inflammatory bowel diseases. Now 24, Curtis began suffering from Crohn’s disease about five years ago. It got so bad, at one point he lost 65 pounds in two months. He was in severe pain, visiting the bathroom up to 30 times a day to pass blood. It was so debilitating, he dropped out of university several times. He tried standard antibiotic treatment, “massive amounts of steroids,” alternative treatments and special diets, all to no avail.
His mother, Sky Curtis, researched bacteriotherapy, hooked up with some supportive doctors, including Dr. Thomas Borody from Australia, an international leader in the field, and a year ago began helping Charlie with fecal transplants, using her own stool.
“In five years I have never felt this healthy,” exclaims Charlie, who last month had a colonoscopy that showed no trace of the disease. “My chest filled up with sunshine. It was amazing.”

published in the toronto Star, Apr 03 2011
http://www.thestar.com/life/health_w..._superbug.html

Last edited by wildbill_52280; 08-10-2013 at 07:31 PM. Reason: wow major typo!! got the date wrong!
08-10-2013, 04:36 PM   #24
sir.clausin
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Ah, ok that´s Skys son, heard about here a friend of mine have spoken to her as guidance while doing FMT. I wonder how that chinese study is going
08-11-2013, 04:44 AM   #25
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is the chinese study for crohns or c.diff?
08-11-2013, 05:28 AM   #26
sir.clausin
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Crohns
http://clinicaltrials.gov/show/NCT01793831
08-11-2013, 06:36 AM   #27
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wow I hope its successful
08-11-2013, 12:18 PM   #28
wildbill_52280
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wow I hope its successful
http://clinicaltrials.gov/show/NCT01793831
scroll down to where it says "assigned interventions".


it states:
Procedure: FMT
Standard FMT, once

then to the scroll down to the detailed description:
Detailed Description:
The present clinical trial aims to re-establish a gut functionality state of intestinal flora through FMT as a therapy for CD. We established a standard bacteria isolation from donated fresh stool in lab. Then the bacteria is transplanted to mid-gut (at least below the duodenal papilla) through regular gastroscope. Patients from multi-clinical centers in this study will be assigned to receive FMT only once or traditional treatments according to associated guidelines and follow-up for at least one year. Blood tests, abdominal X-ray, endoscopy and questionnaire will be used to assess participants at study start and at study completion.

so this study is transplanting it through the oral route/ through a duodenal tube, but only once. Its highly unlikely this will lead to any long term changes, similar to the recent study with one single FMT application through colonoscopy for ulcerative colitis.

at this point i am happy they are trying this for crohn's disease, but afraid that without changing the protocol we will not be able to see the true potential of FMT for Crohns. that's why i say, do not wait for them to be done messing around with this already proven safe therapy. its already been like 30 years since some of the first experiments on UC, even though things are moving quite faster these days in general, they could be moving much faster.
08-11-2013, 04:49 PM   #29
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WildBill, do you know if duodenal tube has a better efficacy rate with Crohn's than enema/colonoscope (either anecdotally or study-wise)? FMT make alot of sense to me - as a Vet student, I'm not really grossed out by it, I'm really intrigued. If I decide to go down the FMT route (trying to get symptoms, etc under control first, as I'm newly diagnosed) I'd like to give it the best chance of working as possible.
08-11-2013, 07:04 PM   #30
wildbill_52280
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WildBill, do you know if duodenal tube has a better efficacy rate with Crohn's than enema/colonoscope (either anecdotally or study-wise)? FMT make alot of sense to me - as a Vet student, I'm not really grossed out by it, I'm really intrigued. If I decide to go down the FMT route (trying to get symptoms, etc under control first, as I'm newly diagnosed) I'd like to give it the best chance of working as possible.
off the top of my head, i dont think its ever been done for crohn's this way yet, at least officially. i believe until we have a fecal transplant pill that's the day you will see great results with crohns, but they have had some good success with daily enemas too. really not much evidence overall though just a few soso studies. buts its the theory and accumulating bulk of science that supports it that is so very strong, urging more studies to be done now. do them right now lots of them lets see what this can do, its safe, and already shows some efficacy. for the most part its started tho, still waiting on that fecal transplant pill tho.
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