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12-06-2016, 06:37 PM   #811
wildbill_52280
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Here is my article/blog on Fecal Microbiota Transplant and its use for IBD. It is a more condensed version of the information on this thread.
http://fecaltransplant2015.blogspot....ibd-fecal.html
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12-13-2016, 03:10 PM   #812
wildbill_52280
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Women had a FMT in 2011 via colonoscopy and claims she is still in remission with no meds to this day. She is one of the lucky ones I guess. If your donor has good stool and the procedure is done well then this is one possible scenario, but always seemed less likely to achieve these results with colonoscopic method rather then enema or nasogastric tube, but i guess it can happen.

http://www.healingwell.com/community...f=38&m=3757835

Last edited by wildbill_52280; 12-13-2016 at 05:49 PM.
12-15-2016, 12:45 PM   #813
wildbill_52280
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Women had a FMT in 2011 via colonoscopy and claims she is still in remission with no meds to this day. She is one of the lucky ones I guess. If your donor has good stool and the procedure is done well then this is one possible scenario, but always seemed less likely to achieve these results with colonoscopic method rather then enema or nasogastric tube, but i guess it can happen.

http://www.healingwell.com/community...f=38&m=3757835
One other thing, I think this was before the regulations on FMT became really strict. Could you imagine there was a time when doctors could have done this to people with IBD 4 years ago? Only after the procedure was shown to be so effective for c diff was when they restricted access to it, it's kind of strange if you ask me. I vaguely recall its use was restricted because now that it was shown to be so good for treat c diff, they MUST protect people who will want to try it, which doesn't make much sense. I would think if it was shown to be so dangerous they would then restrict it for safety reasons and that was never the case so I believe it was restricted mainly for business reasons. Either way the DIY Fecal Transplant was what this thread was always about and maybe now i recall what motivated me to do it, the idea that something so promising had been ignored and misunderstood for a while and then restricted. 3 .5 years after I started this thread and a few good examples of success in IBD, we are still waiting to gain access to this treatment. But I do agree more research needs to be done to learn how to perform a successfull FMT in IBD, It's still a little hard to understand why it's taking so long when stool/bacteria is free and everywhere. Maybe its 150 years of believing bad bacteria is the sole cause of disease that has slowed things down, when we now see many bacteria are good and essential for health.
12-23-2016, 01:17 AM   #814
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Microbiota: Reseeding the gut
Liam Drew
Nature 540, S109–S112 (22 December 2016) doi:10.1038/540S109a
Published online 21 December 2016

http://www.nature.com/nature/journal.../540S109a.html
12-30-2016, 06:31 PM   #815
wildbill_52280
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Openbiome has a full spectrum Fecal Transplant Pill. http://www.openbiome.org/fmtcapsules

These pills are not available to the public, but it would be nice to gain access for IBD studies or personal use as some of us are convinced it could cure us.
Openbiome is a stool bank which provides frozen stool samples to clinics around the USA for the use of performing a Fecal Microbiota Transplant, mainly for C. difficle because FMT is only approved for the use of that condition as of date. A recent trial of a small bacteria selection in an FMT pill failed for C. difficle, so a full spectrum pill is likely more promising and actually has been effective as a regular FMT for C diff in one study.

Last edited by wildbill_52280; 12-31-2016 at 01:44 PM.
01-06-2017, 01:38 PM   #816
Scipio
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Good overview of the state of FMT for IBD recently published in Nature:

http://www.nature.com/nature/journal...f/540S109a.pdf
01-09-2017, 10:46 PM   #817
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Minor correction on this, they may be using the FMT pill form openbiome I was under the impression it was a room temp stable rather then frozen, open biome pill is frozen so this study may be using openbiome's pill.

Viability: 6 months at -20°C; 12 months at -80°C
so you can keep it in a standard freezer for up to 6 months.
http://www.openbiome.org/treatment-information/


Just found this study in Boston, Massachusets, USA using Fecal Transplant pills for the treatment of IBD. They are not recruiting patients yet, I wonder why? either way its pretty cool and this is the second mention of FMT pill study in IBD. Been waiting for this like 3-4 years now. i dont think they are using the pills from openbiome though. https://clinicaltrials.gov/ct2/show/...nsplant&rank=5

Last edited by wildbill_52280; 01-10-2017 at 05:02 PM.
01-10-2017, 12:45 AM   #818
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This study is recruiting patients for UC and using a FMT pill.

https://clinicaltrials.gov/ct2/show/...nsplant&rank=6
01-10-2017, 11:11 AM   #819
Scipio
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Interesting new trial is now recruiting at one site in the UK:

https://clinicaltrials.gov/ct2/show/...=EB8018&rank=1

Trial description:

"Crohn's Disease is a chronic inflammatory disease of the gastrointestinal tract. Emerging evidence suggests that the microbiome plays an important role in triggering an abnormal mucosal immune response in patients with Crohn's Disease. Independent studies have demonstrated an imbalance of the microbiome with a significant increase of E coli with invasive properties, termed adherent-invasive E coli (AIEC). These AIEC bacteria attach to the gut wall of susceptible patients via the fimbrial adhesion protein FimH, and subsequently trigger inflammation by invading and proliferating within the gut wall. EB8018 is an oral small molecule that is designed to block FimH thereby preventing the entry of AIEC into the gut wall thereby disarming the bacteria without disrupting the gut microbiome."
01-15-2017, 09:13 PM   #820
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A clinical trial recruiting for IBS using FMT pills.

https://clinicaltrials.gov/ct2/show/...s+fecal&rank=4
01-19-2017, 04:00 PM   #821
wildbill_52280
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Rebiotix supposedly is testing a new FMT pill in C diff that is shelf stable and doesn't have to be frozen. http://www.rebiotix.com/clinical-tri...ff-prevention/

http://tcbmag.com/News/Recent-News/2...y-Administered
01-23-2017, 05:02 PM   #822
wildbill_52280
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Not related to IBD but FMT study has been done on autism with positive results.

https://news.osu.edu/news/2017/01/23/yes/
02-04-2017, 02:02 PM   #823
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AMazing!! Here is an interview of researchers who did the Fecal Microbiota Transplant study in Autism. They gave daily doses of FMT pills and not only did the patients acquire the donors bacteria, they were able to recruit new bacteria from there environment. So it seems the more your microbiome is restored, the better it is at selecting new bacteria from the environment to add the the community. Which also seems to explain why only a few FMT doses have little effect on IBD.

https://www.youtube.com/watch?v=3N4nZ26aw8Y
02-15-2017, 06:35 PM   #824
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Randomized placebo-controlled research announced at the current ECCO meeting shows significant benefit for FMT in UC patients using multi-donor transplant:

https://www.ecco-ibd.eu/index.php/pu...00a0trial.html
02-19-2017, 11:54 AM   #825
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Randomized placebo-controlled research announced at the current ECCO meeting shows significant benefit for FMT in UC patients using multi-donor transplant:

https://www.ecco-ibd.eu/index.php/pu...00a0trial.html
this study did show greater benefit of FMT compared placebo which is great, and I recall this report by Doctor Borody where they used 3 donors for FMT in Crohn's where the woman seemed completely cured 13 years later.

"When Professor Borody offered this chance of a cure I thought: what if it works?" she said.

"They put a nasal tube down into my small intestine. I had three donors - about 950 mils - and all up it took about five hours."
http://www.abc.net.au/news/2014-03-1...seases/5329836


the day when we get consistent results is hopefully around the corner now that openbiome is manufacturing FMT pills, but i would have hoped this UC study would have more effective using mutiple donors, but there are perhaps other variables to each experiment that aren't listed which would help further explain why one protocol would be more effective over the other.
02-19-2017, 11:56 AM   #826
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Here is more evidence of antibiotics negative effect on the Microbiome.

"Our study shows that the C difficile epidemic was an unintended consequence of intensive use of an antibiotic class, fluoroquinolones, and control was achieved by specifically reducing use of this antibiotic class, because only the C difficile bugs that were resistant to fluoroquinolones went away," Crook explained. "Reducing the type of antibiotics like ciprofloxacin was, therefore, the best way of stopping this national epidemic of C difficile, and routine, expensive deep cleaning was unnecessary."

http://www.infectiousdiseaseadvisor....rticle/634329/
03-14-2017, 10:59 AM   #827
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Really making some progress on FMT pills!! Just waiting for them to be used in IBD!

For the study, UTHealth and Kelsey Research Foundation investigators enrolled 72 patients who had at least three bouts of recurrent C-diff in a clinical trial and treated them with either fresh, frozen or freeze-dried FMT product via colonoscopy. Fresh FMT product produced a 100 percent cure rate among participants; frozen product produced an 83 percent cure rate and freeze-dried product produced a 69 percent cure rate.
Frozen and fresh product fully restored the microbiota diversity among participants within seven days after treatment.

Researchers saw some improvement in microbiota diversity among participants treated with freeze-dried product after seven days and full restoration of healthy bacteria within 30 days.

"This is the first study to show that frozen and freeze-dried microbiota are as good as fresh material, so that we never have to use fresh again. It's a logistical nightmare to use fresh product. If we were going to treat you today, a donor would have come in two hours before, we would have already isolated the sample and then we would have to administer it the same day. A pill form of the product could make all of this easier," said Herbert L. DuPont, M.D., senior author and director of the Center for Infectious Diseases at UTHealth School of Public Health.


Read more at: https://medicalxpress.com/news/2017-...-pill.html#jCp

Last edited by wildbill_52280; 03-14-2017 at 07:32 PM.
03-16-2017, 12:52 PM   #828
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The company Seres created an FMT pill with a select species of bacteria to treat c. difficle infection as a replacement for a traditional Fecal Microbiota Transplant. This recent clinical trial was considered a failure but they are going to do the experiment again and make a few changes to hopefully make the drug more effective.

Seres has said that a misdiagnosis of certain patients in the earlier trial meant that some participants did not actually have C. diff., and that some patients may not have gotten a high-enough dose of SER-109. In the new trial, the company says it will use a more accurate mechanism to measure the infection, and patients will receive a dose that is 10 times higher.
04-05-2017, 01:21 PM   #829
wildbill_52280
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Another company plans to make a FMT pill for IBD. http://www.businesswire.com/news/hom...ration-Develop

I'm still wondering whats going on with the other companies that were supposed to make one. Also we are still waiting on the IBD studies using FMT pills now Openbiome makes them!! So I know they are available to every researcher and doctor now since December of 2016. Pills could have been made manually by scientists with a centrifuge for years now. I'm sure it's all right around the corner though, and it seems that way. I'm an impatient person I guess.

Last edited by wildbill_52280; 04-05-2017 at 05:53 PM.
04-09-2017, 06:54 PM   #830
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An article written by Bill Gates about the microbiome. I'm glad he is now on board with this.

https://www.gatesnotes.com/Books/I-C..._&WT.tsrc=BGTW
04-21-2017, 12:31 PM   #831
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Another example of fecal transplant's benefits beyond C. difficile or IBD.

https://www.sciencedaily.com/release...0421084925.htm
04-28-2017, 04:44 PM   #832
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Study of colonoscopic FMT in U.C. combining multiple donors to increase Bacterial diversity in the dosage. http://journals.lww.com/ibdjournal/A...ota.98583.aspx

This was cool to see another study on FMT but I'm not sure this is enough to demonstrate whether or not a multi donor FMT is more effective then a single donor FMT, it still helps I'm sure, but there are many variables that affect the outcome and if there is little attempt to track them all in one study, it's just going to take longer to improve the success rate. Just waiting for us to use a long term oral dose FMT pill in IBD patients which also ensures a high fiber diet in the patient, maybe that's enough to get a 90% success rate, then we wont need any further manipulations of a protocol.
04-28-2017, 07:37 PM   #833
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Im glad this fallowing trial is already active (second or 3rd FMT trial from this Canadian medical team.) 80 patients will be recruited, that's a pretty big group! Only the donor who gave best results in the previous trial will be used:
https://clinicaltrials.gov/ct2/show/...splant&rank=16
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''UC-like Crohn's'' since 2001:
on: 25mg 6-MP (purinethol)+ B12 shots
minor hands/wrists chronic arthritis since 01/2013

Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only
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pred 50mg, 5-ASA, cortifoam, Imuran (failed) Purinethol (success) methotrexate (failed CD and arthritis).
05-23-2017, 07:24 PM   #834
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Another successful case for FMT in a Crohn's patient. They went from 394 to 132 CDAI score in one week after FMT. This was in Korea.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430018/
05-26-2017, 10:12 AM   #835
wildbill_52280
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This will be one of the most important studies to watch because for the first time they will treat crohn's with a full spectrum FMT pill for 8 weeks. I'm not sure if the dose will be daily or weekly I'm assuming daily but ill have to find out more.

https://vector.childrenshospital.org...itis-children/

https://clinicaltrials.gov/ct2/show/...cy+kahn&rank=3

Last edited by wildbill_52280; 05-26-2017 at 04:35 PM.
06-05-2017, 11:36 PM   #836
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This Genomicist with a Ph.d gave herself a DIY FMT after analyzing her microbiome and hypothesizing that antibiotics she took for lyme disease led to her long term health problems.
http://www.the-scientist.com/?articl...m-Nonathletes/

Last edited by wildbill_52280; 06-06-2017 at 03:49 PM.
06-10-2017, 05:28 PM   #837
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Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report.

Abstract

Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota. Recently, it has been considered as a treatment of Crohn's disease (CD) and certain neurological diseases. Here, to the best of our knowledge, we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy. During the 20 mo of follow-up, FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic drugs. Furthermore, this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota.

https://www.ncbi.nlm.nih.gov/pubmed/28596693
07-07-2017, 11:44 AM   #838
wildbill_52280
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The University of Vermont is recruiting U.C. patients for an FMT study. They will be using an FMT pill daily so it may be a more effective and easier way to perform an FMT then enemas, colonoscopies or nasogastric tubes.
UVM Medical Center: You are still looking for patients for the trial. If somebody’s interested, what do they do?

Dr. Peter Moses: Well, they just contact us. Our trial is registered with the FDA. If you go to clinicaltrials.gov and in the search box type in FMT Vermont, it’ll come right up and the contact information is there. People can contact me and they can contact Megan Phillips who is our study coordinator.

UVM Medical Center: Probably, the easiest way to remember is switchboard at the UVM Medical Center is 847-0000. You could just ask for Dr. Peter Moses or Megan Phillips, as he said.


UVM Medical Center: Your trial is about all ulcerative colitis. Why’d you pick that and what are you finding?

Dr. Peter Moses: Well, ulcerative colitis and Crohn’s disease, the two major forms of inflammatory bowel disease, have long been thought to have to do with the interaction of an individual who may be genetically susceptible and their environment, and the environmental piece has been thought to be their microbiology or their microbiome. There were a number of studies that have been published over the last five, maybe eight years that have been equivocal in their findings, but they’re mostly descriptive so they have to do with a patient’s clinical experience. We felt very strongly that we should back up and try to understand what the science of first disrupting and then replacing someone’s microbiome might be on this immune-mediated disease ulcerative colitis.

Our patients have some testing. Some of it is unique. We’re looking at T-cell function. We’re looking at inflammatory mediators. We’re looking at how much inflammation we can see under the microscope, but we’re also asking them how they feel. Their normal microbiome is disrupted with antibiotics. Then, after that disruption, it’s replaced with an FMT. Then, after the FMT, they undergo daily treatment bacteriotherapy with a capsule containing human stool from the same donor that they received the FMT.

https://medcenterblog.uvmhealth.org/...linical-trial/
07-12-2017, 11:49 AM   #839
Scipio
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Nestle funds a joint venture to use microbiome testing in IBD:

http://www.fiercebiotech.com/medtech...-joint-venture
07-23-2017, 10:59 AM   #840
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Not a remarkably successful study on FMT, but still pretty good.

Sci Rep. 2017 Jul 6;7(1):4753. doi: 10.1038/s41598-017-04984-z.
Multiple fresh fecal microbiota transplants induces and maintains clinical remission in Crohn's disease complicated with inflammatory mass.

Abstract
The ancient Chinese medical literature, as well as our prior clinical experience, suggests that fecal microbiota transplantation (FMT) could treat the inflammatory mass. We aimed to evaluate the efficacy and safety of multiple fresh FMTs for Crohn's disease (CD) complicated with intraabdominal inflammatory mass. The "one-hour FMT protocol" was followed in all patients. Twenty-five patients were diagnosed with CD and related inflammatory mass by CT or MRI. All patients received the initial FMT followed by repeated FMTs every 3 months. The primary endpoint was clinical response (improvement and remission) and sustained clinical remission at 12 months. Secondary endpoints were improvement in size of phegmon/abscess based upon cross-sectional imaging and safety of FMT. 68.0% (17/25) and 52.0% (13/25) of patients achieved clinical response and clinical remission at 3 months post the initial FMT, respectively.

The proportion of patients at 6 months, 12 months and 18 months achieving sustained clinical remission with sequential FMTs was 48.0% (12/25), 32.0% (8/25) and 22.7% (5/22), respectively. 9.5% (2/21) of patients achieved radiological healing and 71.4% (15/21) achieved radiological improvement. No severe adverse events related to FMT were observed. This pragmatic study suggested that sequential fresh FMTs might be a promising, safe and effective therapy to induce and maintain clinical remission in CD with intraabdominal inflammatory mass.
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