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12-14-2017, 04:27 PM   #901
wildbill_52280
Senior Member
 
Join Date: Sep 2009
WANT POOP TRANSPLANTS. HERE'S HOW TO MAKE THEM SAFE, Wired Magazine.

https://www.wired.com/story/patients...ake-them-safe/

“If you ask 99 percent of physicians who do this, they will tell you anything that came along to limit access to stool banks would be catastrophic,” he says. Plus, there’s no guarantee the microbiome even can be successfully be pulled apart and put back together in pill form. “People have spent 50 years trying to come up with synthetic blood and we still have a blood bank," says Stollman. "Who’s to say stool will be any different?”
And this is one reason I put a little more hope into full spectrum fecal transplants. As it has been shown in mice experiments, and in human experiments using whole stool, the more depleted the microbes are, the more resistant the community is in accepting any new species into that community. throwing just a few down there might not stick to well as a cure, they'll just pass on through. But throwing a large diverse amount down there, even though it's a little bit of a "crap shoot", might be the best strategy for the time being.

The first report of cure from Crohn's with FMT was a women who received a large volume FMT through nasogastric tube using 3 donors all in the same day, whereas almost every other experiment using a single donor and enemas took 30-80 FMT enemas.
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Learn How Fecal transplants restore good bacteria that regulate inflammation to induce remission and how it has potential to be a cure for IBD in the future. Follow the link below.
http://www.crohnsforum.com/showthread.php?t=52400
12-19-2017, 05:35 PM   #902
wildbill_52280
Senior Member
 
Join Date: Sep 2009
This study is recruiting pediatric crohn's patients to try an oral FMT pill, the pill is made by Rebiotix.

https://clinicaltrials.gov/ct2/show/NCT03378167
01-04-2018, 05:05 PM   #903
wildbill_52280
Senior Member
 
Join Date: Sep 2009
Sere's Health reported an analysis of a recent study on their bacterial pill SER-287 , it's kind of like a fecal microbiota transplant pill, showing that the bacteria was successfully engrafted/implanted in the G.I. systems of the patients and that the patients improvements were related to how well these bacteria were transplanted. The bacteria was confirmed to still be present 4 weeks after the last dose. I'm wondering how long those bacteria will stay and which species they actually are.

https://www.businesswire.com/news/ho...-1b-Microbiome
01-18-2018, 04:15 PM   #904
wildbill_52280
Senior Member
 
Join Date: Sep 2009
I was just reading a new study on IBD microbiome and genetics and they found very little relationship between genetics and the state of the microbiome, this seems to be an important factor in considering causation of the disease suggesting genes have little to do with it and that the composition of the microbiome itself is a force that acts upon the human body. So again if there was a cure it could very well be by manipulating the microbiome composition such as what is being done with Fecal Microbiota Transplants. https://www.nature.com/articles/ctg201758
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