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Crohn's Disease Forum » Parents of Kids with IBD » Lymphocyte results whilst on Imuran/6MP.


View Poll Results: What range do your or your child's lymphocytes sit at when taking Imuran/6MP?
<0.5 2 22.22%
0.5 - 0.7 1 11.11%
0.7 - 0.9 2 22.22%
0.9 - 1.0 0 0%
>1.0 (normal) 4 44.44%
Multiple Choice Poll. Voters: 9. You may not vote on this poll

07-22-2013, 07:32 AM   #1
DustyKat
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Lymphocyte results whilst on Imuran/6MP.

If you have a child on Imuran/6MP or take either drug yourself what range do your lymphocytes sit at.

Dusty.
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07-22-2013, 08:04 AM   #2
kiny
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Well, I'm not sure I should respond, but there are so few lymphocyte topics.

I'm no longer on imuran (been years), but I do have very low lymphocytes, much lower than the cutoff, I have idiopathc T lymphopenia. they don't watch the absolute count anymore, since it's pointless once you know if it's B or T lymphopenia, but CD4 and CD8, which are the T Cells, my B cells are fine. I get the same things people who have AIDS get, preventive anitbiotics, but I don't get anti-viral treatment, since I'm negative for AIDS. Why I have it...no one knows...it might go away after a few years...but for now the priority is that I don't get infections. If someone has idiopathic T lymphopenia, I am always looking for someone to talk to who has it too since it's very rare.
07-22-2013, 03:42 PM   #3
DustyKat
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That is very interesting Kiny. I am glad you did respond! Thanks.

What I am curious about and would be interested if someone can give me answer. My understanding is the role of Imuran/6MP in IBD is to, well this explains it..

The goal of treatment with azathioprine and 6-MP is to lower the body's production of certain types of white blood cells (lymphocytes) in order to decrease the inflammation in the intestines; however, lowering the number of lymphocytes may increase vulnerability to infections.

http://www.medicinenet.com/crohns_disease/page13.htm
So that being the case should the aim be to have sub normal levels of Lymphocytes, between 0.5 - 1.0, and if it isn't then what is the role of Imuran/6MP if Lymphocytes are in the normal range?

Dusty.
07-22-2013, 03:47 PM   #4
my little penguin
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DS was 0.4 or 0.49 or so while on 6-mp
He never had any issues with colds or anything else.
I think its up higher now on humira.
I have to look what it was on remicade
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07-22-2013, 06:44 PM   #5
Jmrogers4
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Jack's labs below while in Imuran except last one on 2/5 was while on LDN

Standard Range 1.20-6.40 K/UL
2/2/2011 (1.6)
3/7/2011 (2.4)
6/14/2011 (1.8)
5/14/2012 (1.5)
2/5/2013 (2.36)
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Jacqui

Mom to Jack (18) dx Crohn's 2/2010
Vitamin D -2000mg
Remicade - started 1/9/14; 7.5ml/kg every 6 weeks
Centrum for Him teen multivitamin
Past meds: Imuran/Azathioprine; allopurinol; methotrexate; LDN; Prednisone; Apriso; Pentasa; EEN

Husband dx Crohn's 3/1993
currently none due to liver issues

Last edited by Jmrogers4; 07-22-2013 at 06:48 PM. Reason: spacing
07-22-2013, 09:04 PM   #6
Catherine
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Dusty I am posting back to you. The article you posted to me by Miles Sparrow.

What CBC and LFT blood results do you aim for?

The aim of therapy is immunomodulation without immunosuppression, and I aim for a total white cell count of greater than 3.5 x 109/L with a lymphocyte count greater than 1.0 x 109/L, or occasionally slightly lower. Asymptomatic elevations of hepatic transaminases only require dose reduction once they reach more than twice the upper limit of normal.

http://www.healio.com/gastroenterolo...-monitor-patie
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Catherine
Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

Meds: ), azathioprine 200mg, Mesalazine 1.2g x 2, seretide 250 x 2 (asthma), ventolin (as needed)

Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)
07-24-2013, 10:58 PM   #7
DustyKat
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Thanks Catherine!
09-07-2014, 01:56 PM   #8
worriedboy
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Hi,

I know this is an old thread but hopeful to get some answers.
As I have to begin a steroid-sparing treatment, the plan is now 6mp. However, my LYM count baseline is 0.6-0.7 k/ul ...
So I wonder ...

- If with Crohns there are too much white blood cells - how is it that my LYM count is low ??
- If I take 6mp, I guess it will lower my LYM count even more - what is the limit ? I am really worried about that
- Should I prefer a biologic, which targets the TNF-a, thus to my understanding wont effect my WBC count ?


Any help is much appreciated !
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