Share Facebook
Crohn's Disease Forum » Treatment » Humira/Adalimumab » How long does humira take to work?


08-16-2013, 07:59 AM   #1
sam1
 
sam1's Avatar
 
Join Date: Oct 2011
Location: U.K., United Kingdom
How long does humira take to work?

Hi my son has started humira 9 weeks ago and dosnt seem to be getting any improvement, he injects once a fortnight, how long does it take to work?
08-16-2013, 08:33 AM   #2
nogutsnoglory
Moderator
 
nogutsnoglory's Avatar
 
Join Date: Sep 2009
Location: New York

My Support Groups:
It can take up to 12 weeks for a reduction in symptoms. After that I would discuss another option with the GI since it would appear Humira is not helping.

From the Humira website:

"Among patients who were not in response by week 12, therapy continued beyond 12 weeks did not result in significantly more responses."

http://humira.com/Crohns/Faq
08-16-2013, 09:15 AM   #3
sam1
 
sam1's Avatar
 
Join Date: Oct 2011
Location: U.K., United Kingdom
Thanks for reply, getting worried that its not going to work and that theres not a lot else left to try!
08-16-2013, 09:22 AM   #4
nogutsnoglory
Moderator
 
nogutsnoglory's Avatar
 
Join Date: Sep 2009
Location: New York

My Support Groups:
Sorry, I can see how it would be discouraging after 9 weeks. Who knows, maybe it will magically kick in one day soon? I hope it will.

Has he tried Remicade or Cimzia?
08-16-2013, 09:26 AM   #5
Clash
Forum Monitor
 
Clash's Avatar
What other meds has your son tried? There are other biologics such as Remicade and Cimzia though I don't think Cimzia is approved in the UK although I could be totally wrong.

Has he tried any of the immunosuppressants like AZA or methotrexate?

I agree I would be discussing lack of improvement with the GI soon to see what else he may have up his sleeve.

My son went straight to Remicade upon dx, with a short stint of pred, while awaiting remicade approval and ped GI appt. He had no improvement with Pred and improvement right away with Remicade but when we got past the loading doses of Remicade he couldn't last the full 8 weeks without symptoms. His schedule was tweaked, his dose was increased and then we finally added Methotrexate. He was on both MTX and Remicade for 8 months then we dropped the MTX and now he only does Remicade, so far so good.

I do hope he is able to find a treatment to relieve his symptoms soon!
__________________
Clash
Mom to
C age 19
dx March 2012 CD

CURRENT MEDS: MTX injections, Stelara


Dx May 2014: JSpA
8/2014 ileocecectomy
9/2017 G tube

PAST MEDS: remicade, oral mtx, humira
08-16-2013, 09:56 AM   #6
sam1
 
sam1's Avatar
 
Join Date: Oct 2011
Location: U.K., United Kingdom
Hes tried azathioprine, 6mp and methotrexate all sent his liver enzymes sky high! Havnt tried remicade yet, so maybe his consultant will try that next, im worrying that it will be surgery!
08-16-2013, 10:04 AM   #7
Clash
Forum Monitor
 
Clash's Avatar
I posted two links below, the first is a great article/thread on switching biologics and the second a good article/thread on optimizing biologics, you may want to check them out. I would give the Remicade a go if the problems are due to inflammation, if they are due to scar tissue then surgery might be the most feasible route.

http://www.crohnsforum.com/showthread.php?t=42119

http://www.crohnsforum.com/showthread.php?t=42140
08-17-2013, 11:51 AM   #8
cosmic dave
Senior Member
 
cosmic dave's Avatar
 
Join Date: Oct 2011
Location: Sutton on Sea, Lincs, United Kingdom

My Support Groups:
Humira worked for me from day 1. Guess I was lucky. .

2
__________________
Had it since 1987 but try to ignore it

Follow me on twitter @Djcomicdave also at www.thehappyhippyhut.com
08-20-2013, 09:56 AM   #9
Careyearl
 
Careyearl's Avatar
 
Join Date: Jul 2013
Location: Kelowna, British Columbia

My Support Groups:
I have been on Humira for 5 weeks and I am now noticing very slight changes so I feel it is slowly working. I find I'm not as tired as I was.
08-20-2013, 11:05 AM   #10
sam1
 
sam1's Avatar
 
Join Date: Oct 2011
Location: U.K., United Kingdom
Ive been reading up on how long it can take to work, lots say bout 3 mths so we will keep going for bit longer! Thanks for your replies x
08-20-2013, 12:53 PM   #11
nogutsnoglory
Moderator
 
nogutsnoglory's Avatar
 
Join Date: Sep 2009
Location: New York

My Support Groups:
Please keep us posted and don't be too discouraged if this doesn't work out. There are other options.
Reply

Crohn's Disease Forum » Treatment » Humira/Adalimumab » How long does humira take to work?
Thread Tools


All times are GMT -5. The time now is 07:53 AM.
Copyright 2006-2017 Crohnsforum.com