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Crohn's Disease Forum » Treatment » A New Probiotic for Crohn's?


04-14-2009, 06:29 AM   #1
Mazen
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A New Probiotic for Crohn's?

I don't know if this has been posted before but it's a very interesting study:

http://www.ccfa.org/printview?pageUr...ters/probiotic

http://www.pnas.org/gca?gca=pnas%3B0...cked+Abstracts

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

F. prausnitzii exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production. These results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment.

Last edited by Mazen; 04-14-2009 at 06:53 AM.
04-14-2009, 06:50 AM   #2
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As a followup, while researching this bacteria, I found this article:

http://www.pubmedcentral.nih.gov/art...?artid=1392899

in it, it is stated that:

Interestingly, the detection of Faecalibacterium prausnitzii in a strict vegetarian failed (17). In our cross-sectional study we detected the highest levels of the Faecalibacterium prausnitzii cluster in the Swedish study groups, a population whose dietary habits are characterized by a high consumption of fish and meat.

So maybe being a vergetarian with Crohn's isn't a good idea???
04-14-2009, 08:38 AM   #3
D Bergy
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I have seen this someplace before, but I am glad you posted it as I lost the article.

Does anyone know if there is a probiotic available to us that contains this bacteria? In my opinion this is one of the more important findings concerning Crohn's.

I have always done well on a high protein high meat diet. When I deviate from it, I will eventually have problems. I did not have any explanation for it, but possibly this may have something to do with it.

Dan
04-14-2009, 08:51 AM   #4
D Bergy
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There is a product for animals. Looks like animal research on Pigs is producing similar beneficial results. Now if they just made some Progut for humans maybe we could get somewhere with those stubborn cases.

http://www.agriworld.nl/public/file/...1014223643.pdf

Another article that may give us some clues.

http://www.isoflavones.info/isoflavo...testinal-flora

Dan

Last edited by D Bergy; 04-14-2009 at 09:00 AM.
04-14-2009, 09:38 AM   #5
Mazen
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Hi Pen . Goodluck with VSL#3. I know your success with antibiotics, the same for me. Let's hope probiotics do the same

Dan, this is a very interesting finding indeed. Note that most diet that restrict carbs (sugar and starch mainly) like the SCD, have some kind of success in Crohn's. I guess it's mainly because they alter the bacteria in the intestines, starving the bad and keeping the good ones. Here is a link with such info:

http://www.healingcrow.com/dietsmain/crohn/crohn.html
04-14-2009, 09:58 AM   #6
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Hi Pen. Well I was having what seems a flare, with all body ache, tiredness and pain. so I took a 10 day course of 2 Cipro 500 and 3 Flagyl 250 per day and now I'm feeling much better. I'm still on my maintenance meds of 3g Pentasa and 50 mg Imuran. But like you I seem to get better on antibiotics for a while and then get worse. I'm thinking of starting SCD, since I want to stop the Imuran before me and my wife try to get preganant, and I don't think Pentasa alone will do the trick. I hope I get the will to start this diet. It's hard but I once tried it for 2 weeks and it helped a lot. I guess i will start it when I decide to stop the Imuran (LDN and VSL#3 are no option for me since they are not available in my country)....

Last edited by Mazen; 04-14-2009 at 10:00 AM.
04-14-2009, 04:22 PM   #7
D Bergy
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I guess it pays to dig around on cyberspace. I have heard of Chitosan before as a weight loss product, but not in any Crohn's related sense. Here is one lone study from the Czech Republic that shows an increase of the bacteria Faecalibacterium prausnitzii when Chitosan is used in vitro.

http://www.cssm.info/priloha/fm2006_306.pdf

It would be an interesting experiment, in vivo, if someone were to use this readily available product as a prebiotic, for three months or so and see if improvement is noted.

I would try it, but I have no symptoms to resolve presently. Unless you are allergic to shell fish, it really has little to no risk.

Dan
04-15-2009, 03:47 AM   #8
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Hi Pen. Well I used to eat lots of dairy, mainly yoghurt and cheese. But they didn't bother me. Even now I can usually eat yoghurt with no problems. But now lots of info is popping up about cow's milk, especially MAP and certain sugars in it, that I'm thinking of switching to goat dairy product. But MAP can also affect goats so we have to boil the milk to make sure, and prepare our yoghurt at home. Don't know frankly if I can do this ))

Since teenage years I used to have stomach pains but no intestinal problems; doctors put these stomach pains as stress related. My problems started after having several vaccines when I started work at a new company which required extensive travel. 2 months late I developed Crohn's. Coincidence, I don't know??? Everything about this disease is non-conclusive ....
Maybe it was a weak immune system attacked by vaccines, bad food while travelling to turkey and stress that brought things up. who knows....

Last edited by Mazen; 04-15-2009 at 04:07 AM.
04-15-2009, 03:56 AM   #9
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Here is the article that says that Yeast Sugar Also Found in Cow’s Milk Linked to Crohn’s Disease

http://www.dieticiansblog.com/2007/1...0%99s-disease/

Last edited by Mazen; 04-15-2009 at 04:05 AM.
04-15-2009, 08:07 AM   #10
D Bergy
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What kind of stomach pains do you have? Is it burning, cramping or what does it feel like?

Dan
04-16-2009, 01:15 AM   #11
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Hi Dan. Before Crohn's, I used to have major gnawing pain on the upper tip of my stomach. Then I had heartburn lots of times. Strangely when my Crohn's appeared, I didn't have any more stomach pains as before, now it was pain in my lower right quadrant, sometimes cramping pain when I eat something wrong (or when I had an obstruction), sometimes burning pain that travels up on my right side. My stomach started to get upset again whne I took Prednisone, and so I had to take some antiacids for a while for relief.
04-16-2009, 08:58 AM   #12
Mazen
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Hi Pen. No surgeries yet, and no endoscope. I seem to be good for a while, and then have some bad days, usualy cleared by a course of Cipro and Flagyl. My stomach is fine nowadays. I'm trying to give diet and natural stuff a chance before thinking about something more drastic... Goodluck with the VSL#3 and keep us updated on how it goes
04-23-2009, 02:35 AM   #13
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Hi Pen. Any updates on the VSL#3? Hope all is going well with it
04-23-2009, 09:21 AM   #14
D Bergy
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The gnawing pain sounds like an H-Pylori infection. Broccoli, and Mastic Gum is supposed to inhibit growth. I used a more direct method to rid my stomach of it. My use of antacids and acid blocking drugs likely allowed it to move into my stomach.

Dan
04-24-2009, 01:22 AM   #15
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Hi Dan. I had a blood test (the doctor takes a little drop of blood and puts it in a piece of paper or soemthing) and it showed negative for H-Pylori. Broccoli, is a no-no for me. I cannot tolerate it.....
04-24-2009, 05:46 PM   #16
D Bergy
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I had three negative tests for H-Pylori. One was a biopsy. I can only assume that the test only picks up H-Pylori at a certain concentration.

I treated for the bacteria because there simply was not many bacteria that can produce the inflamed stomach that an endoscopy revealed. I used an alternative treatment that most people do not have available to them, but Mastic Gum can also be used.

My relief was in minutes.

Dan
04-27-2009, 03:43 AM   #17
Mazen
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Hi Dan. I have started SCD 3 days ago, so hopefully it will also take care of the bacteria in my stomach; Let's see
09-09-2010, 09:44 AM   #18
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topping this old topic as my GI has me on Align specifically for this bacteria. I'm undiagnosed so take it for what it's worth, but the SCD plus the Align seems to really be improving my symptoms.
09-23-2010, 05:18 AM   #19
Igor_Passau
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Certain bacteria (Klebsiella pneumoniae and Proteus mirabilis) that inhabit the intestine provide the environmental trigger that initiates and perpetuates chronic intestinal inflammation in individuals who are genetically susceptible to inflammatory bowel disease (IBD), a study led by Harvard School of Public Health researchers has found...

more:

_w.cell.com/cell-host-microbe/fulltext/S1931-3128(10)00276-3

and

_ttp://download.cell.com/cell-host-microbe/pdf/PIIS1931312810002763.pdf?intermediate=true
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