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Crohn's Disease Forum » Books, Multimedia, Research & News » Impaired Mitochondria linked to IBD and Autoimmune illness


11-08-2013, 03:03 PM   #1
Passing Through
 
Join Date: Aug 2013
Impaired Mitochondria linked to IBD and Autoimmune illness

Anyone wanting to add further related studies, please feel free. This is not a chicken or the egg thing for me, but addressing Mitochondria damage (through diet changes, antioxidants, etc.) does lead to quality of life.


Stress in mitochondria contributes to chronic inflammatory bowel disease
http://www.sciguru.com/newsitem/8976...-bowel-disease


Oxidative Stress and Mitochondrial Functions in the Intestinal Caco-2/15 Cell Line
http://www.plosone.org/article/info%...l.pone.0011817


Mitochondria and tumor progression in ulcerative colitis.
http://www.ncbi.nlm.nih.gov/pubmed/23852949


Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.
http://www.ncbi.nlm.nih.gov/pubmed/23915129


Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis.
http://www.ncbi.nlm.nih.gov/pubmed/22374887


Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation.
http://www.ncbi.nlm.nih.gov/pubmed/21997551


Tocotrienols have potent antifibrogenic effects in human intestinal fibroblasts.
http://www.ncbi.nlm.nih.gov/pubmed/20684017


Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.
http://www.ncbi.nlm.nih.gov/pubmed/20440543


Experimental colitis is associated with ultrastructural changes in inflamed and uninflamed regions of the gastrointestinal tract.
http://www.ncbi.nlm.nih.gov/pubmed/18408386


Impairment of mitochondrial acetoacetyl CoA thiolase activity in the colonic mucosa of patients with ulcerative colitis.
http://www.ncbi.nlm.nih.gov/pubmed/17483192
11-08-2013, 03:33 PM   #2
GutlessWonder86
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Join Date: Jul 2010
OMG! I was just diagnosed a few days ago with mitochondrial cytopathy.

I'm just reading the information my infectious disease MD gave me.

WOW!! and on top of this, I have MTHFR (genetic mutation) A1298C single heterozygous mutation, am a stroke survivor, have migraines, and Crohn's.

Lucky lucky me.
11-08-2013, 03:35 PM   #3
GutlessWonder86
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Join Date: Jul 2010
Thank you so much for this. I tried to do some research on the web but got so overwhelmed I decided to wait until I saw my PA who is well versed in this disorder.

I wonder how many more IBD patients have this mitrochandrial cytopathy.
11-08-2013, 06:28 PM   #4
Passing Through
 
Join Date: Aug 2013
GutlessWonder86, that sounds awful. I think your question is worth exploring, I just wanted to show a connection with mitochondria in general. Though I can't say impairment and cytopathy are the same, I would imagine one would follow the other. You might investigate ingesting tea leaves, Green, White, Black, and eating red grapes. Good luck.
11-08-2013, 06:52 PM   #5
GutlessWonder86
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Join Date: Jul 2010
can't do green tea. I'm on a blood thinner for the rest of my life. I have to watch what I eat. Can't do grapes either.

The PA has me on OTC enzymes, vitamin C, E, and Co something 10.
11-08-2013, 07:44 PM   #6
GutlessWonder86
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Join Date: Jul 2010
if you find anymore information on this topic, can you please PM it to me.

thanks.
11-11-2013, 08:39 AM   #7
Malgrave
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Join Date: Jul 2012
Location: Belgium

My Support Groups:
I guess these were not included in the original list:

Mitochondrial Gene Polymorphisms That Protect Mice From Colitis

http://www.gastrojournal.org/article...043-3/fulltext

The Other Genome: Mitochondrial DNA and Protection From Experimental Colitis:

http://www.gastrojournal.org/article...rticle-outline
11-11-2013, 07:47 PM   #8
Passing Through
 
Join Date: Aug 2013
Wow those are some good ones, thank you Malgrave.
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