My husband has been on humira for about 1 1/2 with good results (his scope last fall showed no inflammation). Fast forward to this past Monday, he awoke with pain in his lower left abdomen. Called GI doc and he was put on prednisone. Doctor said it could be a flare and to see if the pred calms it down. The pain has diminished about 60% so the doctor wants him to start tapering off prednisone. I have read where you can flare while on Humira even though the Humira is still working. This seems contradictory...Doesn't inflammation cause the pain? If there is inflammation, how can Humira be working?