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Crohn's Disease Forum » Books, Multimedia, Research & News » Smoking, other factors increased risk for extraintestinal manifestations in CD


09-26-2014, 10:42 AM   #1
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Smoking, other factors increased risk for extraintestinal manifestations in CD

Increased risk for extraintestinal manifestations in patients with Crohn’s disease was associated with smoking, need for surgery and younger age at first diagnosis, according to research data.

Researchers from Germany prospectively studied 257 patients newly diagnosed with inflammatory bowel disease (62.6%, Crohn’s disease) from 2004 through 2008 to assess prevalence and risk factors for extraintestinal manifestations (EIMs) during the early course of disease. Median follow-up was 50 months after first diagnosis, during which the investigators collected information on disease development, appearance of different EIMs (peripheral arthropathies, ophthalmologic manifestations, erythema nodosum, pyoderma gangrenosum, sacroiliitis and primary sclerosing cholangitis), need for IBD-related surgery, medical therapies and risk factor exposure.

Throughout the study, EIMs were diagnosed in 63.4% of the total cohort, 42.9% of whom had CD compared with 21.9% of ulcerative colitis patients (at first diagnosis, RR=1.96; 95% CI, 1.3-2.98). Active smoking increased the risk for EIM during early disease course for CD patients but not in UC patients (RR=1.96; 95% CI, 1.01-3.79). Additionally, the need for IBD-related surgery (RR=2.93; 95% CI, 1.2-7.16) and patients aged younger than 40 years (RR=2.4; 95% CI, 1.01-5.23) at first diagnosis also increased the risk for EIM in CD patients.

“We demonstrate a high prevalence of EIMs in a prospective population-based cohort of IBD patients at first diagnosis as well as during the early course of the disease,” the researchers concluded. “In patients with CD, the need of IBD-related surgery, young age at first diagnosis, and active smoking are associated with the development of EIMs, whereas in UC no key risk factors could be identified.”

Http://www.healio.com/gastroenterolo...stations-in-cd
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