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10-21-2014, 10:55 PM   #31
Jennifer
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One thing concerned me in their terms of service. There's a bit in there about how insurance companies and the like sometimes ask whether you have any genetic information and how it could be considered fraud if you did not disclose having the info from their service. I'll probably still go ahead and do it, but might make another push on life insurance first.
Maybe dispose of the info? Or make sure there's no information on it that leads to you specifically.

I thought life insurance only cared about the conditions you've been diagnosed with (clearly I haven't dealt with life insurance yet) but I guess it's possible they ask things like "has anyone in your family been diagnosed with _______?" I'm not entirely sure this test will apply as it's likely no one in your family has been diagnosed with anything you might find on your results.


I received my kit in the mail and sent my sample yesterday. Maybe I'll find out that I don't have Crohn's at all. :P
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Diagnosis: Crohn's in 1991 at age 9
Surgeries: 1 Small Bowel Resection in 1999; Central IV in 1991-92
Meds for CD: 6MP 50mg
Things I take: Tenormin 25mg (PVCs and Tachycardia), Junel, Tylenol 3, Omeprazole 20mg 2/day, Klonopin 1mg 2/day (anxiety), Restoril 15mg (insomnia), Claritin 20mg
Currently in: REMISSION Thought it was a flare but it's just scar tissue from my resection. Dealing with a stricture. Remission from my resection, 17 years and counting.
10-29-2014, 03:12 PM   #32
nogutsnoglory
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The Great Bowel Movement wrote a piece on this http://thegreatbowelmovement.org/23andme-ibd-dna-study/

Apparently 2,500 crohnies have already participated and they are at 25% for their recruitment goal which started in August.
11-04-2014, 08:17 PM   #33
nogutsnoglory
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Got my results! I'm very European which wasn't a surprise but I plugged in my info on genetic genie and have mutations that make folate and b12 conversion difficult. I want to do more digging and am also curious about the genes suspected to influence IBD and where I am on those. Love to hear if anyone got any back yet.
11-05-2014, 01:10 AM   #34
Jennifer
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Haven't gotten mine yet but I'll post when I do.
11-05-2014, 09:58 AM   #35
my little penguin
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3-4 weeks for ds
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11-05-2014, 10:21 AM   #36
Jmrogers4
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Plan on getting it done this week. Kit is out and ready just need to do it. It will be interesting since father is adopted and we really have no idea of ancestry on that side.
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Jacqui

Mom to Jack (18) dx Crohn's 2/2010
Vitamin D -2000mg
Remicade - started 1/9/14; 7.5ml/kg every 6 weeks
Centrum for Him teen multivitamin
Past meds: Imuran/Azathioprine; allopurinol; methotrexate; LDN; Prednisone; Apriso; Pentasa; EEN

Husband dx Crohn's 3/1993
currently none due to liver issues
11-05-2014, 11:46 AM   #37
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I just got my kit yesterday, all I have to do is spit in the tube and mail it in.
11-05-2014, 07:18 PM   #38
DougUte
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I am waiting for my results. Will let you know when I get them.

I already know my ancestry is all European, but I will check the results for any surprises. I want to check on genes that are suspected to be involved in Crohn's.
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Surgery Oct 12, 2010

Crohns Medicines:
Started Humira June 22nd, 2011
Increased to weekly injections on November 1st, 2016
Due to the insurance company, Humira ended on January 31, 2017.
Started Entyvio February 9th, 2017
Loperamide 3 capsules twice a day
Vitamin B6, B12, Folic Acid
Vitamin D3 10000 I.U.
Nature Made Multivitamin
11-11-2014, 04:12 PM   #39
CrohnsChicago
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Just now seeing this post. I'm going to sign up!

I've read about 23 and Me before when they were doing the health reports but I had now clue about this project.

Thanks for sharing NGNG.
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Crohn's-Colitis May 2012
Current Meds:
6-MP (100mg) / Asacol (4800mg)
Past Meds:
Prednisone/ Entocort / Flagyl
Current Supplements:
B12 Shot (1cc/mo) / Multivitamin / Vitamin D (1000iu) / Calcium (1200mg) / Omega 3 Fish Oil (4800mg)
Additional Info:
Anemia/Borderline Anemia - whole life
Generalized Anxiety Disorder - 2009 (Cognitive Behavioral Therapy, mindfulness meditation)

11-11-2014, 05:22 PM   #40
Jennifer
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I got my results. Very European (knew that). 2.8% Neanderthal (not surprising from European decent). Not very Italian. That's not good because I'm supposed to be a quarter Italian. I'm only showing 3.9%. I'm having my sister who has Crohn's do this as well so we can compare our results.
11-11-2014, 06:59 PM   #41
poopaholic
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I have received some of my results already . I am 99.4% European and I also have been contacted by a distance cousin. It has all been very interesting and informative .
11-11-2014, 07:29 PM   #42
nogutsnoglory
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I ran the raw genetic data on a few free and low priced tests and have found I have most of the mutations for crohns but one of them showed a decreased chance of IBD. The others clearly won out.

Some of my other predispositions are also interesting. I have the MTHFR genetic mutation which means I only absorb 30% of folate so I switched to a multi with methylfolate and will continue deplin which is high dose folate. Apparently the MTHFR mutation is responsible for many ailments so I'm hoping I may be able to fix things a bit.
11-12-2014, 09:31 AM   #43
Sea_Star
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Where did you run the health-related genetic tests? 23 and Me no longer does it :/
11-12-2014, 10:03 AM   #44
nogutsnoglory
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A few places will do it for you but most charge.

Geneticgenie.org is free
Interpretome.com is free
Promethease.com is $5
Mthfrsupport.com is $20
Nutrahacker.com has some free, detailed $23
Livewello.com (not sure of cost)

I have done genetic genie and promethease so far but I'm a little obsessed now and want to do more.
11-13-2014, 07:44 PM   #45
my little penguin
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Got the results now to try and figure them out
11-13-2014, 08:39 PM   #46
DougUte
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Got my results. My ancestry is all European, no surprise there. Need to start with geneticgenie.com
11-13-2014, 10:00 PM   #47
my little penguin
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Did Prometheus one..
Very easy and no surprise
Tons of crohns and arthritis genes ...
11-13-2014, 10:21 PM   #48
nogutsnoglory
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Guys be on the lookout for the MTHFR mutation because apparently it's pretty common and a cause for many problems!
11-15-2014, 10:24 PM   #49
DougUte
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I have started playing with my results. Among other things, I noted this:

rs11209026(A;G)
0.26x lower risk for certain autoimmune diseases. Substantially decreased risk of Ankylosing Spondylitis (0.6x), Crohn's Disease (0.37x), Psoriasis (0.6x), and Ulcerative Colitis (0.59x). This is the rare version of the interleukin-23 (IL-23) receptor."

I guess my risk of Crohn's disease was not decreased enough!

I am just starting to figure out how to find specific genes in the data.
11-15-2014, 10:30 PM   #50
nogutsnoglory
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There are over 100 genes thought to be associated with IBD. If you really want to goto town here is a comprehensive list but personally I only checked the most well documented ones so far http://www.snpedia.com/index.php/Crohn's_disease

http://blog.23andme.com/23andme-rese...sease-triples/
11-15-2014, 10:42 PM   #51
my little penguin
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I used promethease it generated a report which sorted out the most common variants of disease including crohns
Ds has a lot
So no doubt genetics played a big role for him
11-15-2014, 11:05 PM   #52
nogutsnoglory
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Did you use genetic genie penguin? That's free and may prove helpful in general.
11-15-2014, 11:34 PM   #53
my little penguin
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Not yet
Promethease report pointed out every disease we already know he has.
Kinda cool but kinda scary
May try gentic genie but his mthfr was ok
11-15-2014, 11:58 PM   #54
nogutsnoglory
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That's good. I think my double mutation for MTHFR may be the cause of many of my non IBD health problems. I'm trying to properly methylate now which if it helps clear toxins and inflammation may help the IBD too. Who knows? All complicated stuff.
11-28-2014, 01:54 PM   #55
Jennifer
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So my sister got her test results back and they don't quite match (we both show ancestry that's similar but then we have some that doesn't match at all, not even close) which they should. So either this test isn't very good (clearly not as good as a blood test but that bad?) or we aren't really related. She's sending both of our results to her old anthropology professor to see what they have to say.

We also compared our results on geneticgenie.org and they don't match there either. Some do but there are some where I'm +/+ and she's -/-.

If anyone else has a sibling with IBD it would be interesting to see if you had the same findings with your sibling or if yours came back the same as your sibling's.
11-28-2014, 02:16 PM   #56
my little penguin
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Jennifer
I "think" from talking to other geeky types
23&me finds your SNP 's which can vary from person to person
Some will be the same within a family but some will be different.
Since they only search 1 million out of the 10 million types each person has -there could be error there
Also if you have certain SNP -then 23&me makes general statements about ancestry
Based on reports of people SNP found originally from that same area .
So again another place for error.
Aslo keep in mind the diseases associated with SNP are just that - maybe one or two papers were published siting SNP xyz was in found a population of people with that disease.

Fun to play with but most genetics have move on to more complex ways of looking into genes and mapping .
12-02-2014, 07:46 PM   #57
syzygy
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Jennifer, do the plusses and minuses refer to Mendelian dominance and recessives or is it code for something else? If Mendelian, it would just mean that your folks are both +/-. (In which case you'd have the same chance of being the "same" or "opposite" of your sib: 25%.)
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12-19-2014, 05:22 PM   #58
Nym
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They wouldn't obtain the report though, it's only shared with us. I wouldnt worry about it to be honest because over 500,000 Americans have signed up with 23andme and just because one has a genetic risk doesn't mean anything will happen. Everyone has genetic risks.
You're right 'everyone has genetic risks' and it is for these risks that these studies aka volunteer data collection are being compiled. Future generations will be at greater ri$k. Sorry, blame my university lol
12-19-2014, 05:33 PM   #59
Nym
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Here's some dot dot dot on 23 and me :

Back to today. When all of this focus on ancestry started up in the 90's I was very concerned about it. Suddenly everyone was on-line posting their family tree and researching their history. Very nice. And convenient. The Nazis had to do all of that work on their own. Now you're doing it for them.

Who owns 23 AND ME? Anne Wojcicki. Who? The wife of Sergey Brin. Who? The founder and owner of GOOGLE. Google is heavily invested in 23 AND ME. What does 23 AND ME do with your data? They keep it. Store it. Analyze it. Inventory and control. Remember? What is UN Agenda 21? It inventories and controls everything. Including you. What will they do with it? Whatever they want. - See more at:

http://www.democratsagainstunagenda2...ew-world-order

Bill Clinton didn't apologise to the Tuskegee survivors for nothing.
12-19-2014, 06:52 PM   #60
nogutsnoglory
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Nym I respect your opinion but billions use Google and while they aren't perfect I don't think anything bad will happen with data. We live in a day and age where very little is private and big brother and companies know so much about us. I don't think this is the one to pick a fight on when there is hope it will help us.
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