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Crohn's Disease Forum » Treatment » Humira/Adalimumab » Humira and depression :(.


12-25-2014, 10:42 PM   #1
Mary:)
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Humira and depression :(.

I have been experiencing very bad depression and mental fogginess. I have been on Humira for 5 years. When I speak with my pharmaceutical company they do as if there are any physical or mental changes. I do have mental changes. Do you think this could be related to Humira?
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DX Crohns-2009

Fistula-2010


Humira-Every 2 weeks 40mg

Prednisone drives me nuts!!!!
12-26-2014, 04:21 PM   #2
sue2003
Yes I do. But not as worse as prednisone.
12-26-2014, 09:00 PM   #3
theOcean
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If you've been on it for five years, I would think it's a bit strange that it would happen suddenly now -- I would expect that more when you initially go on a new medication. Are you on anything else, or is there something else going on in your life that may be influencing how you're feeling mentally/emotionally?
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Diagnosis: Fistulizing Crohn's, 2011 (originally Dx as Ulcerative Pancolitis)
Past Medication: Pentasa, Remicade, Prednisone, Imuran
Current Medication: Humira (biweekly), 100mg 6mp
Unrelated Medication: 36mg Concerta, 75mg Pregabalin
Currently: In remission!
12-27-2014, 06:08 PM   #4
David
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Have you been experiencing fatigue and or tingling in your extremities as well?
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12-27-2014, 06:22 PM   #5
2much
 
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I haven been on Humira for 7 years and I have wondered what the long term effects could be. I am suffering from severe depression right now, as well as, cognitive impairment. I do have neuropathic pain too.
I just decided to stop the Humira without discussing with GI as I know he would not agree. I am in remission and I realize that I am taking a risk but my mental changes are more of a concern right now as I am unable to work. Also, I am experiencing a deep depression like never before. I feel that the unknown long term side effects of Humira was and is very concerning to me. So, I do understand what you are saying.
I may have just made a dumb and risky choice but what is happening to me cognitively and neurologically is more concerning to me. I also want to add that my brain MRI shows atrophy at 3 different areas in my brain. Depression is known to cause atrophy as well as cause a pseudo dementia. Just so much unknown with these very powerful medications
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Undiagnosed for 20 years; diagnosed with IBS
Crohn's Disease diagnosed in 2007
Ileocecal resection surgery 2008.
Currently in remission
Recently diagnosed with moderate to severe cognitive
Impairment and atrophy in Hippocampus and both Parietal lobes in brain

Current Meds include:

Cymbalta
Provigil prn
Protonix
Clonazepam for insomnia
OxyContin
Vicodin prn
Medical marijuana



Have taken:
6 MP
Pentesa
Remicade
Humira
Entocort
Flagyl
Cipro
12-27-2014, 06:32 PM   #6
David
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2much, have you had your vitamin B12 level tested? If so, when, and what was the level?
12-27-2014, 06:53 PM   #7
2much
 
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Yes I have.... A couple of months ago..... I am being worked up in Boston MGH memory disorder clinic. Also had a spinal tap to look for MS and Early Onset Dementia. The spinal tap came back negative.
12-27-2014, 06:56 PM   #8
David
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Do you know what the level came back as?
12-27-2014, 07:19 PM   #9
2much
 
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I think the level came back at 400. I periodically take B12 2500mcg sublingually
02-07-2015, 09:30 PM   #10
Donjh
 
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I've been on humira a little over two years now twice a month, any more info on it causing depression? Anyone experiance this?
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