Share Facebook
Crohn's Disease Forum » Treatment » Humira/Adalimumab » Humira and peripheral neuropathy


01-24-2015, 02:45 PM   #1
Shellyj
 
Join Date: Jan 2015
Location: Reading, Pennsylvania
Humira and peripheral neuropathy

Hi,
My 20 year old daughter was diagnosed with Crohn's in May 2014. Was originally placed on Humira injectable pen weekly for around 4 months with little improvement of symptoms. GI doc then changed to weekly and improvement continued but still with alot of Crohn's symptoms; stomach cramping, diarrhea and developed burning, stinging sensation in both feel and cold sensations - neuropathy. At last GI visit labs were ordered to check B12 levels to see if it was a vitamin deficiency - she is severely anemic as well. Has had 3 iron infusions, takes oral Iron, B12, and the Humira. Labs came back fine no B12 deficiency. Was just wondering if anyone else the neuropathy issues. Was also started on a prednisone and has seen significant improvement in symptoms and may be starting Imuran depending on TMPT genotype results.
01-24-2015, 03:22 PM   #2
DJW
Forum Monitor
 
DJW's Avatar
 
Join Date: Jul 2013
Location: Ontario

My Support Groups:
Hi and welcome.

Sending both of you my support.
__________________
Crohn's Disease
DX 1978 (12 yrs old)
Ileostomy at 19

Visit Crohn's and Colitis Canada:
http://www.crohnsandcolitis.ca/site/...tis_Canada.htm

Living in Ontario with no drug benefits?

Trillium Drug Program:
http://www.health.gov.on.ca/en/publi..._trillium.aspx

Dave
01-25-2015, 07:00 PM   #3
DougUte
Senior Member
 
DougUte's Avatar
 
Join Date: Jul 2010
Location: Kaysville, Utah

My Support Groups:
I haven't heard of neuropathy being a side effect of Humira. Sorry you folks are dealing with this.
__________________
Surgery Oct 12, 2010

Crohns Medicines:
Started Humira June 22nd, 2011
Increased to weekly injections on November 1st, 2016
Due to the insurance company, Humira ended on January 31, 2017.
Started Entyvio February 9th, 2017
Loperamide 3 capsules twice a day
Vitamin B6, B12, Folic Acid
Vitamin D3 10000 I.U.
Nature Made Multivitamin
01-29-2015, 07:13 PM   #4
ti!mbh56
 
ti!mbh56's Avatar
 
Join Date: Feb 2011
Location: San Antonio, Texas
CNS damage, though rare, is a side effect of Humira. Please read the manufacturer documentation always included with the medication and consult you GI Doc.
02-17-2015, 04:26 PM   #5
Roxymusic
 
Roxymusic's Avatar
 
Join Date: Dec 2011
Location: Bloomington, Indiana

My Support Groups:
Shellyj, I was diagnosed in the mid-1990's with neuropathy after years of prednisone therapies. I was also taking a lot of Imuran for moderate to severe Crohn's at the time. The neurologist at the time said prednisone, Imuran and/or Crohns could have caused - take your pick. I went on Lyrica which helped for a while, then the Dr. doubled the dose when it no longer worked. Those two things got me through until the middle of last year when Cymbalta was added which works totally differently than Lyrica. After getting over the side effects of Cymbalta, my neuropathy is well under control. Oh yeah, wife gives me B-12 monthly for over 20 years, nurses for years before that.

Although I have been on Remicade for the last several years, I am going onto Humira next month once the approvals are through. Hot Barbed wire with your feet stuck in a furnace is what my Neurapathy felt like when it was really bad. Oral B-12 didn't work due to surgeries I've had.
__________________
DX Crohn's 1971
Crohn's Surgeries 1971, 1974, 1984x2, 1993, 2007,2016
11 Kidney Stones from 1996 due to resections
All the standard drugs/advice from the 70's 80's 90s
Now: Lyrica & Cymbalta (Neuropathy)
Fish Oil, B12 injection monthly
Dec 21 2011 started Remicade
February 2012 off of Pentase!
Nov 2014 Back on Imuran
Jan 2015 off Remicade
Mar 2015 on Humira
June 2016 on cimzia
Dx short Bowel July 2017
06-09-2015, 09:22 AM   #6
Wilder
 
Join Date: Apr 2013
Location: Birmingham, Alabama
I tried Humira as well as all the other meds in this class (Cimzia, Remicade). While these meds seemed to keep the Crohn's in remission, I chose to stop them due to side effects which included peripheral neuropathy. While these symptoms appear to be extremely rare, they do occur in some patients. Lyrica has helped me. Stopping the meds causing the issues has allowed me to reduce the amount of Lyrica I take. Best of luck!
Reply

Crohn's Disease Forum » Treatment » Humira/Adalimumab » Humira and peripheral neuropathy
Thread Tools


All times are GMT -5. The time now is 07:12 PM.
Copyright 2006-2017 Crohnsforum.com