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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Anyone had to stop due to liver/kidney issues?


01-31-2015, 01:23 AM   #1
aideen33
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Anyone had to stop due to liver/kidney issues?

Im undergoing testing due to unexplained edema in one leg. GI and PCP have said that while it is possible this is steroid related as Im just now tapering after being on since June 2014, they are concerned that it could be liver or kidney problems and GI says that is a concern with Azathioprine. Im hoping its not b/c the Imuran- Humira combo seems to work. Wondering if anyone has seen/experienced this sort of thing?
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Homeschooling Mom of 2 special needs kids, grad student in special ed. & geek girl.
Dx'ed (June '14) Crohn's colitis w/ possible small bowel involvement, Pyloric Stenosis. Asthma, Multiple allergies, pre-diabetic, unexplained tachycardia, hypertension, restless leg, and pos. ANA, waiting for rheum. referral for possible lupus
Meds: Azathioprine, Methyprednisolone, metoprolol ER, Lomotil, Tramadol, Protonix, flexeril, ropinirole, farxiga, vits D, b12, biotin, fish oil, glucosamine
02-05-2015, 08:59 PM   #2
Catherine
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I know there are members on here who have stopped azathioprine due to liver issues.
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Catherine
Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

Meds: ), azathioprine 200mg, Mesalazine 1.2g x 2, seretide 250 x 2 (asthma), ventolin (as needed)

Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)
02-06-2015, 12:28 AM   #3
InkyStinky
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Hey Aideen! Have you got your labs back yet?

A few years back I had elevated liver levels while on 6-MP. My GI at the time just monitored me frequently and they dropped back to normal. I think whether or not it's advisable to just "wait and see" depends on how elevated your levels are.
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Sabrina
IBD diagnosed 1990 @ 8yrs old (current dx: Crohn’s); Blood clots 12/2009 (DVT, bilateral PE)
6MP: 50mg/day

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02-06-2015, 01:37 AM   #4
Robrich
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I was on 6mp and remicade. Was doing fine but they kept upping my 6 mp to get the levels into the "effective" range. High bilirubin!? no worries! I was extremely fatigued for weeks on end then I became jaundiced my skin was dry and scaley and I realized my liver was shutting down just like having Hep. I quit the 6 mp and it cleared up in 48 hours. Stayed in remission for many years after just on Remicade.
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DX. Crohns 50 yrs. with fistulas for 20 years until remicade
Meds: MTX,ENTYVIO 9/14' augmentin,
pred. 10mg.
probiotics
d3, calcium, k2' magnesium, resveratrol,
Turmeric,paleo, bone broths
Past: humira no response after 6 mos., remicade amazing for 10 years then stopped working.
Entocort
6mp, Imuran never helped nasty side effects liver problems, caught pneumonia
Asacol, rowasa no response
Flagyl worked well but got PN cipro same.
02-06-2015, 03:56 AM   #5
aideen33
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Finally got labs drawn on Wednesday morning. hopin they will be back and will call in the morning cause my follow up appt isnt til the 18th and thats a while to be wondering. Swelling has gone down on the Lasix but that only tells me there was fluid retention not *why*
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