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Crohn's Disease Forum » Books, Multimedia, Research & News » New drug for Crohn's disease shows early promise


03-19-2015, 04:38 AM   #1
mf15
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New drug for Crohn's disease shows early promise

Increases TGF-Beta signaling ,down regulates SMAD7.
Old Mike
http://medicalxpress.com/news/2015-0...ase-early.html

much more
http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407250

looks like they knew this stuff back in 01 and prior, took this long
http://www.jci.org/articles/view/12821

this is interesting SMAD7 increases with chronic dietary iron loading
food fortification comes to mind
http://asheducationbook.hematologyli...1/532.full.pdf

Last edited by mf15; 03-19-2015 at 05:50 AM.
03-19-2015, 08:15 AM   #2
FrozenGirl
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A short trial but very interesting. Thanks for posting.
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03-19-2015, 06:37 PM   #3
rollinstone
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Wish we could fast forward time by a few years haha so many exciting things in the pipe line.
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03-19-2015, 09:39 PM   #4
Lady Organic
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from the article: ''Because the active compound of mongersen is released in the terminal ileum and right (proximal) colon, we excluded patients with known lesions in the stomach, proximal small intestine, transverse colon, or left colon.''

This treatment seems promising. Hopefully they can come up with a component that can be released anywhere/everywhere in the digestive track.
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03-19-2015, 10:18 PM   #5
wildbill_52280
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this sounds great!

resveratrol affects tgf beta.
http://onlinelibrary.wiley.com/doi/1.../ibd.21843/pdf

colostrum contains tgf beta
http://www.ncbi.nlm.nih.gov/pubmed/15113633
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Last edited by wildbill_52280; 03-19-2015 at 10:41 PM.
03-19-2015, 10:32 PM   #6
rollinstone
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this sounds great!

resveratrol affects tgf beta.
http://www.ncbi.nlm.nih.gov/pubmed/15113633

colostrum contains tgf beta
http://www.ncbi.nlm.nih.gov/pubmed/15113633

Wild bill, you've linked the same studies, thanks for the effort, but just wondering, does resveratol effect tgf positively or negatively?
03-19-2015, 10:42 PM   #7
wildbill_52280
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Wild bill, you've linked the same studies, thanks for the effort, but just wondering, does resveratol effect tgf positively or negatively?
just fixed it!

resveratrol tgf-beta.
http://onlinelibrary.wiley.com/doi/1.../ibd.21843/pdf

i use resveratrol and it make a difference in how i feel and my observable symptoms.
03-19-2015, 11:55 PM   #8
Crohn2357
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Nestle Modulen IBD is also rich in Transforming Growth Factor Beta 2 (TGF-2)
03-20-2015, 03:58 AM   #9
sir.clausin
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Im going to be negative and say, we dont need these maintenance drugs. We need a CURE god damn it! But off course I do understand the purpose and companies are still trying to make money out of us, as much as they can. That keeps moving things forward, but Im betting all my money on Professor John-Hermon Taylor and Thomas Borody.

Anti MAP vaccine
03-20-2015, 06:07 AM   #10
Mattie
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Me too sir.clausin!
03-20-2015, 09:21 AM   #11
copeland
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Im going to be negative and say, we dont need these maintenance drugs. We need a CURE god damn it! But off course I do understand the purpose and companies are still trying to make money out of us, as much as they can. That keeps moving things forward, but Im betting all my money on Professor John-Hermon Taylor and Thomas Borody.

Anti MAP vaccine
That is pretty negative, considering these researchers are dedicating their lives to trying to help you (and all of us).

What if the MAP vaccine (which is not the subject of this thread btw) is a failure? Should we not try anything else since you have an unproven belief in it?
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03-20-2015, 12:04 PM   #12
xeridea
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That is pretty negative, considering these researchers are dedicating their lives to trying to help you (and all of us).

What if the MAP vaccine (which is not the subject of this thread btw) is a failure? Should we not try anything else since you have an unproven belief in it?
I tend to agree with the position that we should keep an open mind about the cause of Crohn's. It could be MAP, it could be IEC, it could be dysbiosis, it could be immune dysfunction. Until a definitive cause is found and subsequently a cure, it is important to treat the disease and keep its damaging effects at bay. These antisense drugs provide a lower risk profile than some of the current treatments, so it's a positive development that should be welcomed.

Yes, drug companies want to make a profit. They are no different than any other business, and they need to be rewarded for the capital risks they take. I would rather that they are there looking for safer, more effective treatment than they not be there at all. Even socially conscious businesses must operate from a profit perspective or else they will not last.

And don't be surprised if when Dr. Hermon-Taylor's MAP vaccine proves out in early stage trials, he license it to a big pharma company. It's the nature of the business. Researchers have to license out their discoveries to bring them to market. It won't happen otherwise. Dr. Borody sold his formulation to RedHill Bio to take to Phase III trials.
03-21-2015, 03:54 AM   #13
boax
 
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just fixed it!

resveratrol tgf-beta.
http://onlinelibrary.wiley.com/doi/1.../ibd.21843/pdf

i use resveratrol and it make a difference in how i feel and my observable symptoms.
Wildbill, this was very interesting (thanks!) but also raises a few questions.

The new drug down regulates SMAD7, which in turn inhibits TGFbeta-1. They state in the trial report that TGfbeta-1 is an immunosuppressive cytokine. Thus this lowers inflammation by effectively increasing TGFbeta-1. However, in the resveratrol study you linked, the 100mg/kg dose actually lowered TGFbeta-1. Furthermore, in the resveratrol study they state that TGFbeta-1 is a profibrotic factor (causing fibrosis and strictures). Anyway, it seems that (at a high enough dose) resveratrol actually does the opposite of what this drug tries to do. However, pro-inflammatory cytokines were also decreased with intake of resveratrol, but through other mechanisms. If TGFbeta-1 is indeed fibrotic this will likely show up in long term use of the new drug. Resveratrol seems to be very beneficial but it doesn't seem to help TGFbeta-1 like the new drug does.
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