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Crohn's Disease Forum » Books, Multimedia, Research & News » Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence


04-23-2015, 10:53 AM   #1
mf15
Senior Member
 
Join Date: Jun 2012
Location: Pennsylvania
Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

FYI: Something new just popped up, difficult read.
Old Mike
http://gut.bmj.com/content/early/201....full.pdf+html
04-24-2015, 12:44 PM   #2
wildbill_52280
Senior Member
 
Join Date: Sep 2009
this is a great study, id prefer to address these issues in the fecal transplant thread, but i was waiting for a mouse model of IBD based on changes in the microbiome, and this is kind of a step in that direction. This is the first time I've heard of them transferring "IBD" into another mouse, they have done this with obesity in mice already.

what was really cool is that they could influence where the inflammation occured by giving the mice antibiotics. This supports my previous belief that one of the main differences in uc and crohn's is the type of pathogens that exist. But more importantly, it is strong evidence for the sole cause of IBD to originate from the microbiome and not genetics. This supports the idea of fixing the microbiome issues with a fecal transplant, which could then correct the disease itself.
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Crohn's Disease Forum » Books, Multimedia, Research & News » Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence
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