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Crohn's Disease Forum » Books, Multimedia, Research & News » Ozanimod a new class of drug for IBD...


05-23-2015, 12:37 AM   #1
Lady Organic
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Ozanimod a new class of drug for IBD...

http://www.medscape.com/viewarticle/845008

Ozanimod, a novel sphingosine 1-phosphate receptor modulator, is safe and effective in the treatment of patients with moderate to severe ulcerative colitis, according to results from the phase 2 TOUCHSTONE study.

"Ozanimod 1 mg induced clinical remission at week 8, the primary end point, and met all three secondary end points," said William Sandborn, MD, from the University of California, San Diego.

"And the favorable benefit–risk profile supports the planned phase 3 trial and the phase 2 study in Crohn's disease," he reported here at Digestive Disease Week 2015.



Anyone understands how this drug is different from immuno-supressor or Biologics and if it appears less invasive?
__________________
''UC-like Crohn's'' since 2001:
on: 25mg 6-MP (purinethol)+ B12 shots
minor hands/wrists chronic arthritis since 01/2013

Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only
suppl Curcuminoid extract, Inulin,psyllium, apple pectin, Vitamin D

past meds:
pred 50mg, 5-ASA, cortifoam, Imuran (failed) Purinethol (success) methotrexate (failed CD and arthritis).
05-23-2015, 04:36 AM   #2
HelenMelb
 
Join Date: Mar 2013

My Support Groups:
Thanks for the info. As you say, an interesting new class of drug- it does sound as though it has immune-suppressing qualities-check out this link on the University of Michigan FB page:
https://www.facebook.com/UMIBD/photo...7618482585218/

It apparently has a similar mechanism to fingolimod, which is approved for MS. The wikipedia page on fingolimod is a bit concerning in terms of side effects, but hopefully Ozanimod is a better version with a safer profile

http://en.wikipedia.org/wiki/Fingolimod#Side_effects
05-23-2015, 07:36 AM   #3
mf15
Senior Member
 
Join Date: Jun 2012
Location: Pennsylvania
I have been trying to figure this stuff out for about a year.
Interesting that plant-type sphingolipids called sphingadienes cannot be metabolized to S1P and instead enhance the metabolism of S1P by increasing SPL levels. Vegetarians get UC but perhaps not that many.
Old Mike

http://medicalxpress.com/news/2014-1...ship-diet.html



whole paper

http://www.jci.org/articles/view/74188



why is it interesting-Different approach to UC.

now have to try and figure out what it is modulating and how,which way since it is experimental they probably wont say much,need to find patents perhaps,do we want more or less

S1P,or more or less SPL

http://medicalxpress.com/news/2014-1...e-colitis.html



press release they are only using one mg,

http://ir.receptos.com/releasedetail...leaseid=878411



MS drug

http://medicalxpress.com/news/2013-0...ctal.html#nRlv



target lymphocyte traffic in UC consists of the sphingosine-1-phosphate receptor agonist fingolimod (FTY-720).

http://www.nature.com/mi/journal/v7/...mi201373a.html



Older stuff

caramel coloring inhibits SPL

http://news.healingwell.com/index.php?p=news1&id=527857

might be more than one caramel

http://www.emaxhealth.com/1506/coke-...ent-90-percent



also a MAP connection

http://www.academia.edu/523040/Role_...fferent_lipids




B6 connection

http://www.ncbi.nlm.nih.gov/pubmed/24183308




good paper explains much but confusing as hell on what to do

http://www.ncbi.nlm.nih.gov/pmc/arti...#b79-ceg-7-205




more confusing stuff possible extra bleeding

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617958/


more stuff cancer older

http://jn.nutrition.org/content/134/5/1157.full

Last edited by mf15; 05-23-2015 at 07:51 AM.
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