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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Starting Imuran tomorrow. Quick Question!


07-21-2015, 11:29 PM   #1
Malicious
 
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Starting Imuran tomorrow. Quick Question!

Hi guys!

I'm starting Imuran tomorrow with 50mg tablets.

It sounds like a lot to me, but my specialist said it was a small dose. Just wondering what other doses people had to take.
07-22-2015, 01:39 AM   #2
Becca1991
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Hi, when I first was put on Imuran I took 50mg tablets and gradually increased them up to 150mg a day
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Dx Terminal Ileitis Oct 09 (Age 17)
6/6/12- 12/6/12: Mini flare but gastro doc put it down to stomach bug
2/2/15-?: Mini flare awaiting calprotection levels. Calprotection levels: normal

Current Meds
Azathioprine 50mg
Allopurinol 100mg

Been on
Azathioprine 50mg x3
Humira April-August 2010
Prednisone October 2009-July 2010
Folic Acid
Multi Vitamins
Calcium 2500g
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Ranitadine 2x 150mg
B12 injection
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07-22-2015, 02:32 AM   #3
Catherine
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My daughter started on a 50mg, she was 44 kg.

When your first blood test?
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Catherine
Mother of Sarah dx aged 16, Jan 2012
DX - CD 1/12, asthma
Small bowel to small bowel fistula

Meds: ), azathioprine 200mg, Mesalazine 1.2g x 2, seretide 250 x 2 (asthma), ventolin (as needed)

Currently no supplements.

Has previously taken Multi B, Caltrate, B12 & Iron

Prednisolone (from 30 mg 01/02/2012 to 17/06/2012, 30mg 24/10/12-28/12/12, 50mg 24/1/13-27/4/13)
07-22-2015, 03:06 AM   #4
Malicious
 
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Thanks, Becca!
So if anything the dose will go up, not down.

Thanks, Catherine!
My blood test will be in four weeks - when I'll also go back to see the specialist.

I'm just hoping if it's a small dose, the side-effects are less likely to occur.
07-22-2015, 06:26 AM   #5
Catherine
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The standard practice in Australia is for blood tests weekly for the first 6 weeks after starting imuran.

After you sure your GI wanted to wait 4 weeks for the blood test?


See DustyKat post in this thread.

http://www.crohnsforum.com/showthread.php?t=73196

Last edited by Catherine; 07-22-2015 at 08:41 AM.
07-22-2015, 08:17 AM   #6
Malicious
 
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Yeah positive
07-22-2015, 06:05 PM   #7
hawkeye
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When I first started I was on either 50mg or 75mg daily, it was 24 years ago so I can't remember the exact dosage.
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Current Medications: None currently. Was on Imuran (150mg/day) and 5-ASA (3000 mg/day) as maintenance meds prior to surgery
Surgeries: Left hemicolectomy 2014.
07-25-2015, 05:28 AM   #8
DustyKat
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Have you had an TMPT test done?

It is quite routine to start on 50mg if you havenít had a TMPT test or are awaiting the results of one to lessen the risks of adverse effects if donít tolerate the drug.

With the advent of Thiopurine metabolite testing dosing is normally calculated on metabolite levels rather than weight which is 2-2.5mg per kilo.

My daughter was 34 kilos when she was started on Imuran. At that time TMPT testing wasnít available in Australia nor was Thiopurine metabolites. Her dose has never been adjusted because she has remained in remission.

My son was also commenced on Imuran 50mg at diagnosis whilst awaiting his TMPT result. When it returned with positive results for the enzyme needed to break the drug down he was upped to 100mg (2mg per kilo and he was 50 kilos). Some time later when Metabolite testing was available he had the test done and based those results his dose was reduced to 75mg.

Dusty. xxx
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