Hi All,
Some of you may know me from other treads discussing antibiotics in Crohn's, and know that I've had huge success with this after being told there was no treatment left for me. Wondering if any of you have considered this therapy for your children in light of this study:
http://ir.redhillbio.com/releasedetail.cfm?releaseid=797192
Short version is that Dr. Borody treated 10 children up to 9 years with a combo of antibiotics, probably clofazimine, clarithromycin and rifabutin, and achieved an 80% remission rate. That's not bad! The phase 3 trial of this started in 2014 and is ongoing. However, if my kids came down with this, I'd probably jump to this as a first line therapy due to this comment:
"Results of the retrospective analysis also showed a particularly close relationship between treatment with the anti-MAP combination and clinical response in patients naïve to immunosuppression agents commonly used for treatment of Crohn's disease. Adverse events were mild with none necessitating dose adjustment."
Also, Dr. Borody said in a beststory.ca interview that he's achieved an almost 100% remission rate in treatment naive patients. Since other parts of the world have been treating pediatric patients this way for years with great success, and all the involved drugs are FDA approved, is there any reason not to consider this? It seems like the greatest benefit is when the patient does this therapy right from the start without other immunosuppressives to create resistance.
I'm interested in your thoughts and if parents consider this as a first line option for their kids, and if not, why?
As an aside, it's so difficult to deal with this disease as an adult patient; I can't imagine what you all go through with your children. My fervent hope is that your children all find relief from this terrible disease. Who knows, maybe I'll eventually be in your position since my kids have inherited my crummy genetics. This study at least gives me a bit of hope.
Some of you may know me from other treads discussing antibiotics in Crohn's, and know that I've had huge success with this after being told there was no treatment left for me. Wondering if any of you have considered this therapy for your children in light of this study:
http://ir.redhillbio.com/releasedetail.cfm?releaseid=797192
Short version is that Dr. Borody treated 10 children up to 9 years with a combo of antibiotics, probably clofazimine, clarithromycin and rifabutin, and achieved an 80% remission rate. That's not bad! The phase 3 trial of this started in 2014 and is ongoing. However, if my kids came down with this, I'd probably jump to this as a first line therapy due to this comment:
"Results of the retrospective analysis also showed a particularly close relationship between treatment with the anti-MAP combination and clinical response in patients naïve to immunosuppression agents commonly used for treatment of Crohn's disease. Adverse events were mild with none necessitating dose adjustment."
Also, Dr. Borody said in a beststory.ca interview that he's achieved an almost 100% remission rate in treatment naive patients. Since other parts of the world have been treating pediatric patients this way for years with great success, and all the involved drugs are FDA approved, is there any reason not to consider this? It seems like the greatest benefit is when the patient does this therapy right from the start without other immunosuppressives to create resistance.
I'm interested in your thoughts and if parents consider this as a first line option for their kids, and if not, why?
As an aside, it's so difficult to deal with this disease as an adult patient; I can't imagine what you all go through with your children. My fervent hope is that your children all find relief from this terrible disease. Who knows, maybe I'll eventually be in your position since my kids have inherited my crummy genetics. This study at least gives me a bit of hope.