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Crohn's Disease Forum » Surgery » Fistulas, Fissures and Abscesses » Fistula - alternative to the biological



03-03-2016, 02:29 PM   #1
sam101
 
Join Date: May 2015
Location: Rijeka, Croatia
Fistula - alternative to the biological

Hello... My brother has Chron, and recently he had his perianal abscess drained. His abscess is healing, but his GI told him that it could very likely be fistula, and scheduled him for a MR and also put him on some sort of an antibiotic. She told him that if it shows it is fistula, she we will put him on a biological medication. However he is terrified of biological medication and it's side effects. Did anyone of you try some alternative medication before using biologic ones. Did it do you any good?
03-03-2016, 03:05 PM   #2
JaimeM
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Theres flagyl and cipro.. But it may not work and by that time the fistula could get worse. Surgery is about the only other option I know of. Biologics aren't bad at all.. They take care of several aspects of Crohns which is great.
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Diagnosed Terminal Ileum Crohns 2008
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Switched to Cimzia but didn't work 2015
Back to Remicade and added Azathioprine 2016
03-04-2016, 02:22 PM   #3
sam101
 
Join Date: May 2015
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She told to start taking cipro. After the MR, she will decide what to do next. If shows fistula she will put him on some bilogical mediacation. What is that cipro. Did anyone take him? What are the ups and downs?
03-05-2016, 11:25 AM   #4
Bufford
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Cipro was a miracle drug for me at first. The GI recommended taking Cipro and Azathioprine long term. After a couple of years the drugs went against me and I was forced off. I had torn rotory cuffs, and constant pulled muscles while on Cipro and at first I didn't make the connection that it was the fault of Cipro. To make it short, I had to go off because the drug almost killed me due to toxicity overloading my liver causing Jaundice. Today I cannot take Cipro as I developed an allergy to it.

I went all natural for 10 years, but I am having more trouble controlling the bleeding from two rectal fistulas. I tried Remicade, it worked for the first couple of infusions, but side effects forced me off. Going to go the all natural route; Stress control, diet, and pain control work best for me. If they get worse, I'll likely go the surgical route, the chemicals have always let me down at some point.
03-05-2016, 01:35 PM   #5
ronroush7
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Wish you the best. Keep your doctor appraised of what is going on.
03-05-2016, 05:49 PM   #6
Salad_Shooter
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Cipro has been a nightmare for me. 2 doses and I ended up with ruptured achilles tendons and torn ligaments. I've been in a boot cast for 3 weeks and will be in it for at least 3 more. This may require surgery.

Never again for Cipro or Levaquin.
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End Stage Severe Fistulizing Crohn's Disease (Diagnosed 40 years ago)
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03-05-2016, 09:18 PM   #7
Echodog
 
Join Date: Jun 2013
Biologics are made of human antibodies. They have been a miracle for most of us that have been on them. Remicadee worked for me until it didn't. Humira as well. I'd rather do a biologic (especially if my dr recommended it) than a steroid....


03-09-2016, 10:47 AM   #8
Silverbird
 
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Like some people already said: biologicals aren't that bad They have very little side-effects, and especially with Remicade: IF he gets serious side effects, the nurses and doctors are always close because he'll get it in the hospital. They'll usually just get him off the meds immediately and give some corticosteroids. So I think biologicals are quite safe actually
It's less invasive than serious surgery, and antibiotics usually don't work with fistulae/abscesses.

Good luck to your brother! It's a hard thing to go through.
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Crohn's disease since Dec 2012 | Perianal abcesses & fistula since June 2009

Remicade 300mg/6weeks | 6MP 25mg & Allopurinol 100mg every other day
03-09-2016, 10:58 AM   #9
ronroush7
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Biologics are made of human antibodies. They have been a miracle for most of us that have been on them. Remicadee worked for me until it didn't. Humira as well. I'd rather do a biologic (especially if my dr recommended it) than a steroid....
I would much rather have it than a steroid.

03-09-2016, 01:32 PM   #10
Salad_Shooter
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Remicade uses human and mouse proteins to create a chimeric monoclonal antibody. Enbrel and Entyvio are derived by introducing human DNA into Chinese hamster ovary cells, creating a genetically engineered protein.
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