Poring over genetic information from more than 86,000 people of European ancestry (50,000+ subjects, 35,000+ controls), researchers have discovered that five inflammatory diseases, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and primary sclerosing cholangitis, share a common genetic basis. That is, variations in these sets of genes predispose people to development of any or a combination of these diseases.
Though they've identified hundreds of genes, here's the five with the highest probability:
1) rs3184504 / SH2B3 (prob. 0.978) This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
2) rs367569 / TNP2 (prob. 0.961)
3) rs2266961 / UBE2L3 (prob. 0.963)
4) rs6058869 / DNMT3B (prob. 0.953)
5) rs61839660 / IL2RA (prob. 0.943) Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T cells.
Though they've identified hundreds of genes, here's the five with the highest probability:
1) rs3184504 / SH2B3 (prob. 0.978) This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
2) rs367569 / TNP2 (prob. 0.961)
3) rs2266961 / UBE2L3 (prob. 0.963)
4) rs6058869 / DNMT3B (prob. 0.953)
5) rs61839660 / IL2RA (prob. 0.943) Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T cells.